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GENMAB A/S

BY:

/s/ Anthony Pagano

Name: Anthony Pagano

Title: Senior Vice President, Finance and Corporate Development

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Exhibit

Description of Exhibit

99.1

Genmab A/S Annual Report 2019

Innovating antibodies, improving lives Annual Report 2019 Genmab A/S CVR No. 21 02 38 84

Table of Contents Management’s Review Financial Statements Genmab In Short ................................... 4 — HuMax-IL8 ..................................... 40 — Camidanlumab tesirine (ADCT-301) ................ 41 — JNJ-61186372 .................................. 41 — JNJ-63709178 .................................. 41 — JNJ-64007957 .................................. 42 — JNJ-64407564 .................................. 42 — JNJ-67571244 .................................. 42 — JNJ-63898081 .................................. 43 — Lu AF82422 .................................... 43 Financial Statements for Shareholder Letter ................................ the Genmab Group ................................ 10 80 2019 Achievements ............................... 13 Consolidated Key Figures ........................... 14 Financial Statements for Genmab’s IPO on Nasdaq in the U.S. ................. the Parent Company .............................. 15 138 2020 Outlook .................................... 16 Key 2020 Priorities ................................ 17 Directors’ and Management’s Statement ............... on the Annual Report ............................. Research and Development Capabilities 18 154 Products and Technologies ......................... 20 Product Pipeline .................................. Independent Auditor’s Report ...................... 21 155 Pre-clinical Programs .............................. 43 Approved Products in Collaboration .................. ........................................ 24 Glossary 158 — DARZALEX® (daratumumab) ....................... 24 — Arzerra® (ofatumumab)........................... 30 Antibody Technologies ............................. 45 — DuoBody Platform ............................... 46 — HexaBody Platform . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 — DuoHexaBody® Platform.......................... 51 Proprietary Products in Development ................. 32 — Tisotumab vedotin .............................. 32 — Enapotamab vedotin ............................ 34 — HexElect® Platform .............................. 52 — HexaBody®-DR5/DR5 (GEN1029) .................. 35 — Epcoritamab (DuoBody®-CD3xCD20) ............... 35 — DuoBody-PD-L1x4-1BB (GEN1046) ................. 36 — DuoBody-CD40x4-1BB (GEN1042) ................. 36 Corporate Governance ............................. 55 Corporate Social Responsibility...................... 58 Human Capital Management ........................ 59 Risk Management ................................. 61 Financial Review .................................. 66 Partner Programs Built on Genmab’s Innovation ........ Shareholders and Share Information ................. 38 71 — Ofatumumab (OMB157) .......................... 39 — Teprotumumab ................................. 40 Board of Directors ................................. 74 Senior Leadership ................................ 78 Table of Contents 2

Management’s Review Management’s Review 3

Genmab In Short Genmab is an international bspioetceicahlinzionlgoginy tchoempany creation and of differentiated danevtieblodpymtehnetr apeutics for the treatment of cancer Management’s Review / Genmab In Short 4

D9KK6B 2019 year-end market cap D1KK0,971M 2019 year-end cash position 2* Approved Products in Collaboration DARZALEX® marketed in the U.S., Europe, Japan and multiple other countries Arzerra® marketed in the U.S. and Japan 2 Categories of Cancer Generate products to treat solid tumors and hematological cancers 2,638 Operating Result ~20 Pre-clinical Projects Extensive partnered and own pre-clinical pipeline 6 Proprietary** Antibody Products in Clinical Development Tisotumab vedotin, enapotamab vedotin, HexaBody-DR5/DR5 (GEN1029), epcoritamab (DuoBody-CD3xCD20), DuoBody-PD-L1x4-1BB (GEN1046) and DuoBody-CD40x4-1BB (GEN1042) 35 INDs Investigational new drug applications filed by Genmab and partners since 1999 2015 2016 2017 2018 2019 D5KK,366M 2019 revenue 77% increase versus 2018 D2KK,728M 2019 operating expenses 87% invested in R&D 4 Proprietary Technologies DuoBody® platform, HexaBody® platform, DuoHexaBody® platform & HexElect® platform Dual-listed in Denmark and U.S. * In January 2020, teprotumumab approved as TEPEZZA™ in U.S. ** Tisotumab vedotin 50:50 partner with Seattle Genetics, DuoBody-PD-L1x4-1BB and DuoBody-CD40x4-1BB 50:50 partner with BioNTech Management’s Review / Genmab In Short 5 (DKK million) 1,3441,380 1,053 730

Genmab – we are… Our Vision By 2025, our own product has transformed cancer treatment, and we have An international, dual-listed, biotechnology company Antibody experts inspired by nature to develop differentiated antibody therapeutics to transform cancer treatment Determined to make a difference for cancer patients Creators of two marketed partnered products – DARZALEX and Arzerra a pipeline of knock-your-Developing a strong clinical and pre-clinical pipeline via our passion for innovation and a deep understanding of antibody biology antibodies socks-off Pioneers in technology platforms that help create differentiated, best-in-class or first-in-class products with the potential to improve patients’ lives Inventors of the DuoBody, HexaBody, DuoHexaBody and HexElect technologies A partner of choice with multiple strategic collaborations to expand our capabilities and advance innovation Building commercial capabilities to market our own products in the future A team of highly skilled and educated employees Management’s Review / Genmab In Short 6

Our Three-pronged Strategy Focused on Cancer Millions of people are diagnosed with cancer each year. Cancer is the second leading cause of death worldwide, with about 1 in 6 deaths attributed to cancer. We believe antibody therapies are one of the keys to improving the lives of patients living with cancer. Our antibodies target two main categories of cancer: solid tumors and hematological cancers. Focus on core competence Identify the best disease targets Solid Tumors A solid tumor is an abnormal mass of tissue that usually does not contain any liquid or cysts. Solid tumors may be malig-nant (cancerous) or benign (non-cancerous). Solid tumors can occur in several places in the body including the bones, muscles and organs. Sarcomas and carcinomas are examples of solid tumors. Develop unique first-in-class or best-in-class antibodies Develop next generation technologies Turn science into medicine Create differentiated antibody therapeutics with significant commercial potential Build a profitable and successful biotech Maintain a flexible and capital efficient model Hematological Cancers Hematological cancers, also called blood cancers, begin in the tissues that form blood, such as the bone marrow, or in the cells of the immune system. The three main types of blood cancers are leukemia, lymphoma and myeloma. Maximize relationships with partners Retain ownership of select products Management’s Review / Genmab In Short 7

Approved Products in Collaboration Building a Knock-Your-Socks-Off Pipeline Genmab is building a strong pipeline of proprietary antibody products that have the potential to make a real impact on the lives of cancer patients. When we consider which programs to develop, we look for differentiated antibodies that are first-in-class, offer better efficacy than current treatments, or are better tolerated, and have the potential to improve outcomes for cancer patients. In this way we are building a knock-your-socks-off (KYSO) pipeline that offers multiple possibilities for success and the potential to meet our 2025 vision, while also balanc-ing the risks inherent in drug development. Our KYSO pipeline includes the following proprietary products: DARZALEX® (daratumumab) Arzerra® (ofatumumab) • • • • • • • Tisotumab vedotin1 Enapotamab vedotin HexaBody-DR5/DR5 (GEN1029) Epcoritamab (DuoBody-CD3xCD20) DuoBody-PD-L1x4-1BB (GEN1046)2 DuoBody-CD40x4-1BB (GEN1042)2 DuoHexaBody-CD37 (GEN3009)3 Approved in combination with other standard therapies in frontline multiple myeloma in the U.S., Europe and Japan Approved in certain territories for various chronic lymphocytic leukemia (CLL) indications Approved in combination with other therapies in relapsed/refractory multiple myeloma in the U.S., Europe and Japan 2019 net sales by Novartis of USD 17 million – DKK 23 million in royalties to Genmab We are also working on an extensive portfolio of pre-clinical programs to fuel our pipeline of the future and bring us closer to achieving our 2025 vision. Approved as a monotherapy for heavily pretreated or double-refractory multiple myeloma in the U.S. and Europe 1 Tisotumab vedotin in 50:50 partnership with Seattle Genetics, 2 DuoBody-PD-L1x4-1BB (GEN1046) and DuoBody-CD40x4-1BB (GEN1042) in 50:50 partnership with BioNTech 3 IND filed Q4 2019 2019 net sales by Janssen of USD 2,998 million – DKK 3,132 million in royalties to Genmab Please see pages 24-31 of this Annual Report for detailed indication and safety information. Management’s Review / Genmab In Short 8

Cor Vatu s

Shareholder Letter Dear Shareholder, Genmab’s 20th anniversary year was truly a momentous one for the company, with breakthroughs achieved in all areas of our business. We advanced our innovative proprietary pipeline through additional products in the clinic and a variety of new strategic partnerships. Genmab’s partnered products also made tremendous progress with exciting data and multiple regulatory submissions and approvals. In addition to these developments with our pipeline, we more than accomplished our goals with our extremely successful Initial Public Offering (IPO) in the U.S., making Genmab a dual-listed company. “We more than accomplished our goals with our extremely successful IPO in the U.S.” Management’s Review / Shareholder Letter 10

2020 ofatumumab will become a new treatment option for patients with RMS. Nasdaq Copenhagen in Denmark and the Nasdaq Global Select Market in the U.S. Completed in July, the public offering and listing of American Depository Shares (ADSs) on the Nasdaq Global Select Market under the symbol “GMAB” led to gross proceeds from the issuance of new shares of USD 582 million (DKK 3,873 million) with a corresponding increase in share capital of 3,277,500 ordinary shares or 32,775,000 ADSs. This was the largest U.S. equity issuance by a biotechnology company in 2019, the second largest U.S. IPO ever by a biotechnology company and the largest IPO of ADSs by a European healthcare company. Early-stage Pipeline Expansion Our early-stage proprietary pipeline had unprecedented progress in its development over the course of 2019. We began the year with four Genmab owned (at least 50% ownership) products in clinical development and as of the end of the year this total was raised to six as DuoBody-PD-L1x4-1BB (GEN1046) and DuoBody-CD40x4-1BB (GEN1042), our products in co-development with BioNTech, entered into the clinic. With an investigational new drug (IND) filing for DuoHexaBody-CD37 in mid-November, we anticipate this total will soon be at seven, with more INDs planned for the coming year. We further broadened and strengthened our pipeline with multiple new strategic partnerships including an exclusive worldwide license and option agreement with Janssen for the development of HexaBody-CD38, a next-gen-eration human CD38 monoclonal antibody product; a collaboration with Tempus to combine their sequencing capabilities and industry-leading platform of integrated clinical and molecular data with Genmab’s state-of-the-art translational, biomarker and target discovery expertise; and in December, we entered into an agreement with CureVac that will focus on the research and development of differenti-ated mRNA-based antibody products. DARZALEX Moves Into Frontline This year was also a transformational one for DARZALEX, which is being developed and commercialized by Janssen Biotech, Inc. (Janssen), as over 100,000 patients have now been treated with DARZALEX since its launch in 2015. Approaching triple-blockbuster status for use in relapsed or refractory multiple myeloma, in 2019 DARZALEX received key approvals for newly diagnosed multiple myeloma as well as approvals and regulatory submissions for vastly more convenient modes of administration. In June, following review under the U.S. Food and Drug Administra-tion’s (U.S. FDA) Real-Time Oncology Review (RTOR) pilot program, DARZALEX was approved in combination with lenalidomide and dexamethasone for newly diagnosed patients with multiple myeloma who are not eligible for autologous stem cell transplant (ASCT). This same indication was approved in Europe in November. An additional frontline indication, in combination with bortezomib, thalidomide and dexamethasone was approved in the U.S. in September. The key distinction with this approval is that it was for patients eligible for ASCT, making this the first quadruplet therapy approved for this patient population. Along with these new indications, the option to split the first infusion of DARZALEX over two days was approved in both the U.S. and in Europe. Even more convenient dosing may potentially be possible in 2020 based on Janssen’s regulatory submis-sions for approval of the subcutaneous formulation of daratumumab in the U.S. and in Europe. If approved this new formulation could become a game-changer as it reduces the time needed for dosing of daratumumab from several hours to just five minutes. This IPO was more than just an impressive one-time event; it allows us to diversify our shareholder base, support our growth into new competencies – including Translational Research, Data Sciences, Medical Affairs and Commercial – and it also increases Genmab’s visibility as a world-class antibody innovation powerhouse within the biotechnology industry and among key thought leaders in academia and the financial community. Commitment to Building a Sustainable and Socially Responsible Biotech Along with the Board of Directors and Senior Leadership at Genmab, I am committed to Genmab’s business-driven Corporate Social Responsibility (CSR) strategy as well as our efforts to build a sustainable organization that meets environment, social and governance (ESG) criteria of relevance to our business operations. Our CSR Committee is chaired by a member of our Executive Management Team and is comprised of representatives from a variety of development functions. Together, their goal is to ensure that Genmab carries out our CSR activities effectively and proactively communicates the results. In 2020, our goal is to review ESG considerations in closer detail and to integrate these into our strategic planning and risk management process. To this end, I am pleased to report that in 2020 we will form our first ever sustainability task force, which will be Ofatumumab in Relapsing Multiple Sclerosis Following spectacular data in relapsing multiple sclerosis (RMS) in the third quarter of the year, the focus for ofatu-mumab now shifts to its potential in that indication. The highly anticipated data from the Phase III ASCLEPIOS I & II studies of subcutaneous ofatumumab was presented at the 35th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS). The trials met both the primary endpoints and key secondary endpoints with a safety profile in line with observations from prior Phase II results. Novartis, which is developing and commercializing ofatumumab, has stated that based on this data, they initiated a submission to U.S. health authorities for ofatu-mumab in RMS at the end of 2019. We are hopeful that in Largest U.S. Equity Issuance by a Biotech in 2019 Of key importance in 2019 was our U.S. IPO, which enabled us to become a dual-listed company, trading on both the Management’s Review / Shareholder Letter 11

chaired by myself, to determine ESG matters of relevance to our business operations and establish clear goals to measure our performance. Delivering on Genmab’s Promise Taken together, the events of the past year reveal a bright and exciting future for Genmab. We have delivered on our promise of building a robust and innovative pipeline of antibody therapeutics that creates value for both patients and for shareholders, and yet we are only at the beginning. Genmab is on a transformational journey both as a compa-ny, which grew by 200 employees in 2019, and as we work to revolutionize cancer treatment. I would like to thank the patients who participate in our clinical trials, the investiga-tors who help us trailblaze innovations, our shareholders who believe in our commitment to transform cancer treatment and the dedicated team of Genmab colleagues who are determined to achieve our 2025 vision through our world-class expertise in antibody biology, innovation and technology. Sincerely yours, Jan van de Winkel, Ph.D. President & Chief Executive Officer Management’s Review / Shareholder Letter 12

2019 Achievements Business Progress Priority Achieved Targeted Milestone • U.S. FDA decision on Phase III MAIA multiple myeloma (MM) submission • U.S. FDA decision on Phase III CASSIOPEIA MM submission • Phase III COLUMBA MM subcutaneous daratumumab safety and efficacy analysis Daratumumab • Phase III ASCLEPIOS I & II relapsing multiple sclerosis SubQ ofatumumab study completion and reporting Ofatumumab • Phase II innovaTV 204 tisotumab vedotin recurrent / meta-static cervical cancer study enrollment complete by mid-year Tisotumab Vedotin • Phase II enapotamab vedotin expansion cohort efficacy analysis • Phase I/II HexaBody-DR5/DR5 initial clinical data • Phase I/II epcoritamab (DuoBody-CD3xCD20) clinical data dose escalation cohorts • File INDs and/or CTAs for 3 new product candidates Innovative Pipeline * * Initial data now anticipated in 2020 product pipeline, and the increase in new employees to support the expansion of our product pipeline. Financial Performance • Revenue was DKK 5,366 million in 2019 compared to DKK 3,025 million in 2018. The increase of DKK 2,341 million, or 77%, was mainly driven by higher DARZALEX royalties and milestones achieved under our daratumumab collabo-ration with Janssen. • Operating income was DKK 2,638 million in 2019 com-pared to DKK 1,380 million in 2018. The improvement of DKK 1,258 million, or 91%, was driven by higher revenue, which was partly offset by increased operating expenses. • Operating expenses increased by DKK 1,083 million, or 66%, from DKK 1,645 million in 2018 to DKK 2,728 million in 2019 driven by the advancement of tisotumab vedotin and enapotamab vedotin, additional investments in our • 2019 year-end cash position of DKK 10,971 million, an increase of DKK 4,865 million, or 80%, from DKK 6,106 million as of December 31, 2018. Management’s Review / 2019 Achievements 13

Consolidated (DKK million) Key Figures 2015* 2016* 2017* 2018* 2019 Revenue (DKK million) Income Statement 5,366 Revenue Research and development expense General and administrative expense Operating expenses Other income Operating result Net financial items Net result 1,133 (488) (91) (579) 176 730 27 764 1,816 (661) (102) (763) – 1,053 77 1,187 2,365 (874) (147) (1,021) – 1,344 (280) 1,104 3,025 (1,431) (214) (1,645) – 1,380 232 1,472 5,366 (2,386) (342) (2,728) – 2,638 221 2,166 2,365 1,816 Balance Sheet 2015 2016 2017 2018 2019 Cash position** Non-current assets Assets Shareholders' equity Share capital Investments in intangible and tangible assets 3,493 235 3,903 3,487 60 135 3,922 341 5,238 4,827 60 33 5,423 544 6,603 6,272 61 89 6,106 1,028 8,461 8,014 61 478 10,971 1,183 15,144 14,048 65 111 Operating Expenses (DKK million) R&D G&A 2,728 Cash Flow Statement Cash flow from operating activities Cash flow from investing activities Cash flow from financing activities Cash and cash equivalents Cash position increase/(decrease) 311 (481) 643 874 833 328 (1,015) 91 307 429 1,589 (668) 215 1,348 1,501 1,015 (1,778) (71) 533 683 1,326 (1,983) 3,660 3,552 4,865 763 579 Financial Ratios 1,431 2,386 Basic net result per share Diluted net result per share 13.05 12.56 19.83 19.22 18.14 17.77 24.03 23.73 34.40 34.03 2015 2016 2017 2018 2019 Year-end share market price Price / book value 917.50 15.67 1,173.00 14.67 1,029.00 10.04 1,067.50 8.19 1,481.50 6.85 FTE at Year End FTE 548 Shareholders' equity per share Equity ratio 58.57 89% 79.98 92% 102.51 95% 130.32 95% 216.12 93% Average number of employees (FTE)*** Number of employees (FTE) at year-end 180 186 196 205 235 257 313 377 471 548 * As disclosed in note 1.2 of the financial statements, prior period amounts have not been adjusted under the modified retrospective method to adopt IFRS 16 as of January 1, 2019. Further, 2017 and prior period amounts have not been adjusted under the modified retrospective method to adopt IFRS 15 as of January 1, 2018, and in accordance with the transitional provisions of IFRS 9, comparative figures for 2017 and prior have not been restated. ** Cash, cash equivalents and marketable securities. *** Full-time equivalent. The key figures and financial ratios have been prepared on a consolidated basis. The financial ratios have been calculated in accordance with the recommendations of the Association of Danish Financial Analysts (2017) and key figures in accordance with IFRS. 2015 2016 2017 2018 2019 Management’s Review / Consolidated Key Figures 14 377 257 186205 1,645 342 1,021 214 102 147 874 91 661 488 3,025 1,133

Genmab’s IPO on Nasdaq in the U.S. Genmab Completed a U.S. IPO and is now Dual-Listed on the Nasdaq Copenhagen in Denmark and the Nasdaq Global Select Market in the U.S. In July 2019, Genmab successfully completed an initial public offering (IPO) of American Depositary Shares (ADSs) on the Nasdaq Global Select Market. This achievement makes Genmab a dual-listed company listed on both the Nasdaq Copenhagen in Denmark and the Nasdaq Global Select Market in the U.S. Rationale Behind the U.S. IPO To raise capital to continue the development of our proprietary product candidates, to continue our pre-commercial activities, to continue building our commercial capabilities, and to advance clinical-stage product candidates. Financial Highlights of Genmab’s U.S. IPO On July 22, 2019, gross proceeds from the issuance of new shares amounted to USD 506 million (DKK 3,368 million) with a corresponding increase in share capital of 2,850,000 ordi-nary shares or 28,500,000 ADSs The underwriters exercised . in full their option to purchase an additional 427,500 ordinary shares or 4,275,000 ADSs bringing the total gross proceeds of the offering to USD 582 million (DKK 3,873 million), which was completed on July 23, 2019. The public offering price of USD 17.75 per ADS, corresponded to a subscription price of DKK 1,181.80 per New Share at the U.S. dollar/DKK exchange rate of DKK 6.6580 per USD 1.00 on July 17, 2019, multiplied by the ADS-to-share ratio of ten-to-one. Underwriting commissions paid were USD 32 million (DKK 213 million). Expenses related to the issuance amounted to DKK 25 million. Total share capital following the public offering amounted to DKK 64,967,643. Genmab’s Planned Use of Proceeds • Advancement of tisotumab vedotin to commercialization in recurrent and/or metastatic cervical cancer, to prog-ress tisotumab vedotin in other solid tumor indications and to continue building our commercial capabilities in connection with the potential future approval of tisotumab vedotin; and • Continued investment in our drug discovery efforts, to further our development of existing and new technology platforms, and to fund the development of earlier stage clinical and pre-clinical programs including: • Ongoing development of enapotamab vedotin in various solid tumor indications; • Ongoing Phase I/II clinical trial of HexaBody-DR5/DR5 for the treatment of solid tumors; • Ongoing Phase I/II clinical trial of epcoritamab (DuoBody-CD3xCD20) for the treatment of B-cell malignancies; and • Launch and conduct of Phase I/II clinical trials follow-ing submission of INDs and/or Clinical Trial Appli-cations (CTAs) in 2019 for DuoBody-PD-L1x4-1BB, DuoBody-CD40x4-1BB and DuoHexaBody-CD37. • Maximize relationships with partners, to increase strategic flexibility to potentially retain significant ownership and value of select products and product candidates and for general corporate purposes. ADS Definition An ADS is a U.S. dollar-denominated equity share of a for-eign-based company available for purchase on an American stock exchange. GMAB The ADSs were listed and began trading on July 22, 2019 on Nasdaq Global Select Market in the U.S. under the symbol “GMAB.” Genmab ordinary shares listed on the Nasdaq Copenhagen in Denmark under the symbol “GEN” also began trading under “GMAB” as of July 22, 2019.

2020 Outlook Operating Result We expect our operating income to be in the range of DKK 850 – 1,250 million in 2020 compared to DKK 2,638 million in 2019. 2019 Actual Result 2020 Guidance (DKK million) Revenue Operating expenses Operating income 4,750 – 5,150 (3,850) – (3,950) 850 – 1,250 5,366 (2,728) 2,638 Outlook: Risks and Assumptions In addition to factors already mentioned, the estimates above are subject to change due to numerous reasons, including but not limited to the achievement of certain milestones associated with our collaboration agreements; the timing and variation of development activities (including activities carried out by our collaboration partners) and related income and costs; DARZALEX sales and corresponding royalties to Genmab; and currency exchange rates (the 2020 guidance assumes a USD/ DKK exchange rate of 6.5). The financial guidance assumes that no significant agreements are entered into during 2020 that could materially affect the results. Revenue We expect our 2020 revenue to be in the range of DKK 4,750 – 5,150 million, compared to DKK 5,366 million in 2019. Our revenue in 2019 included DKK 1,684 million related to one-time sales milestones for DARZALEX net sales exceeding USD 2.5 billion and 3.0 billion in a calendar year. Our projected revenue for 2020 primarily consists of DARZALEX royalties of DKK 4,075 – 4,475 million. Our 2020 guidance for DARZALEX royalties represents a 30% to 43% increase compared to 2019. Such royalties are based on estimated DARZALEX net sales of USD 3.9 – 4.2 billion. We project cost reimbursement income of approximately DKK 475 million which is related to our collaborations with Seattle Genetics and BioNTech. The remainder of our revenue is approximately DKK 200 million and consists of milestones and other royalties. Operating Expenses We anticipate our 2020 operating expenses to be in the range of DKK 3,850 – 3,950 million, compared to DKK 2,728 million in 2019. The increase is driven by the advancement of our clinical programs, particularly epcoritamab (DuoBody-CD3x-CD20) and DuoBody-PD-L1x4-1BB. Management’s Review / 2020 Outlook 16

Key 2020 Priorities Priority Targeted Milestone • Tisotumab vedotin1 – Phase II innovaTV 204 safety and efficacy analy-sis in recurrent/metastatic cervical cancer and engage U.S. FDA for BLA submission subject to trial results • Tisotumab vedotin – data on other solid tumor types • Enapotamab vedotin – data to support late stage development • Epcoritamab (DuoBody-CD3xCD20) Phase I/II – decision on recom-mended Phase II dose and initiate expansion cohorts • HexaBody-DR5/DR5 Phase I/II – advance dose escalation • DuoBody-PD-L1x4-1BB2 Phase I/II – initiate expansion cohorts • DuoBody-PD-L1x4-1BB initial data in H2 2020 • File INDs and/or CTAs for 2 new products Genmab proprietary* products • U.S. FDA and EMA decision on Phase III COLUMBA multiple myeloma SubQ submission • sBLA and MAA Submission Phase III ANDROMEDA amyloidosis • sBLA and MAA submission Phase III APOLLO multiple myeloma Daratumumab3 • U.S. FDA decision on regulatory dossier submission in RMS Ofatumumab4 • U.S. FDA decision on Phase III OPTIC active thyroid eye disease submission Teprotumumab5 * Certain product candidates in development with partners, as noted. 1 50:50 dev. w/ Seattle Genetics; 2 50:50 dev. w/ BioNTech; 3 In dev. by Janssen; 4 In dev. by Novartis; 5 In dev. by Horizon Therapeutics. Management’s Review / Key 2020 Priorities 17

Research and Development Capabilities At Genmab, we are inspired by nature and understand how antibodies work. We are deeply knowledgeable about antibody biology and our scientists exploit this expertise to create and develop differentiated antibody therapeutics. We utilize a sophisticated and highly automated process to efficiently generate, select, produce and evaluate human antibody therapeutics. Our research and development teams have established a streamlined process to coordinate the activities of product discovery, pre-clinical testing, manufac-turing, clinical trial design and execution, and regulatory submissions across Genmab’s international operations. Through our expertise in antibody drug development, we pioneer technologies that allow us to create differentiated and potentially first-in-class or best-in-class products with the capacity for improving patients’ lives. Our antibody expertise has also enabled us to create our cutting edge technology platforms: DuoBody, HexaBody, DuoHexaBody and HexElect. We are also transforming ourselves by building on our world-class research in antibodies to expand our capabilities beyond the lab. We are expanding our scientific focus to use data science and artificial intelligence to discover new targets and biomarkers and bolster our in-depth translational medicine laboratory capabilities. All of this is in an effort to get the right antibody product to the right patient at the right dose. laboratory buildings in the Netherlands. The R&D Center houses state-of-the-art laboratories including an advanced robotics lab, a modern auditorium, science café and innova-tive brainstorm and meeting rooms. Located in close proximity to other life science companies and universities, this space provides a bright, open and collaborative atmosphere to enable the Genmab team to continue to innovate and find new ways to help cancer patients. In order to accommodate Genmab’s growth we have also signed an agreement to occupy the first and second floors of the new “Accelerator” building, a multi-tenant building that will be connected directly to the R&D Center and which will be built to achieve the same BREEAM Excellent high sustainability standard. Completion of this building, which will contain both offices and laboratories, is expected in early 2022. In addition, Genmab has opened its first translational medicine research laboratories in the U.S., in Princeton, New Jersey. These laboratories are currently located at the Biolabs Princeton Innovation Center but will eventually be housed within Genmab’s own U.S. office space. This new space, which is being modeled on the open and collaborative spirit of the R&D center in Utrecht, will include both offices and laborato-ries and is anticipated to be complete in the spring of 2020. The opening of the Princeton translational research laborato-ries allows Genmab to expand its translational pre-clinical and clinical drug development research expertise and is part of the strategic growth of the company. Genmab’s discovery and pre-clinical research is conducted at its Research and Development Center in Utrecht, the Nether-lands. The building is one of the first BREEAM Excellent Management’s Review / Research and Development Capabilities 18

Antibody Discovery and Development Analyze clinical trials and apply for marketing approval with regulatory authorities Target discovery, antibody identification and purification Antibody format research to maximize safety and efficacy Phase II/III development to explore efficacy Biochemical analysis Investigate efficacy and mechanism of action in laboratory tests (in vitro) Phase I/II development to explore safety 10 4 Submission of protocol to regulatory authorities Screen for efficacy in animal models (in vivo) to start clinical trials 7 Test antibody binding to human and animal tissue and conduct pre-clinical toxicity experiments Antibody production for clinical development Biomarker and translational research Management’s Review / Antibody Discovery and Development 19 y a 1 12 11 2 3 9 8 5 6

Products and Technologies Product Pipeline Marketed Products Proprietary (≥ 50% ownership) Products in Development Partner Programs Built on Genmab’s Innovation Pre-clinical Programs Antibody Technologies – DARZALEX (daratumumab) – Arzerra (ofatumumab) – Tisotumab vedotin – Enapotamab vedotin – HexaBody-DR5/DR5 – Epcoritamab – DuoBody-PD-L1x4-1BB – DuoBody-CD40x4-1BB – Ofatumumab – Teprotumumab – HuMax-IL8 – Camidanlumab tesirine – JNJ-61186372 – JNJ-63709178 – JNJ-64007957 – JNJ-64407564 – JNJ-67571244 – JNJ-63898081 – Lu AF82422 – DuoBody Platform – HexaBody Platform – DuoHexaBody Platform – HexElect Platform Management’s Review / Products and Technologies 20

Product Pipeline At the end of 2019 our own and partnered product pipeline consisted of eighteen antibodies in clinical development, including two approved products in collaboration as well as approximately 20 in-house and partnered pre-clinical programs. An overview of the development status of each of our clinical-stage product candidates is provided in the following sections. Detailed descriptions of dosing, efficacy and safety data from certain clinical trials have been disclosed in company announcements and media releases published via the Nasdaq Copenhagen stock exchange. Additional information is available on Genmab’s website, www.genmab.com. Management’s Review / Product Pipeline 21

Products in Development APPROVED PRODUCTS IN COLLABORATION AND PROPOSED LABEL EXPANSIONS Product Target Rights Disease Indications Most Advanced Development Phase Pre-clinical I I/II II III Launched Genmab on net global sales) on net global sales) leukemia (CLL)1,2 PROPRIETARY PRODUCT3 CANDIDATES Product Target Rights Disease Indications Most Advanced Development Phase Pre-clinical I I/II II III Launched Seattle Genetics (HuMax-AXL-ADC) (GEN1029) (DuoBody-CD3xCD20) (GEN1046) 4-1BB BioNTech (GEN1042) 4-1BB BioNTech DuoHexaBody-CD37 (GEN3009) Management’s Review / Products in Development 22 Tisotumab vedotin TF50:50 Genmab /Cervical cancer Ovarian cancer Solid tumors Enapotamab vedotin AXLGenmabSolid tumors HexaBody-DR5/DR5 DR5Genmab Solid tumors Epcoritamab CD3, CD20Genmab Hematological malignancies DuoBody-PD-L1x4-1BB PD-L1,50:50 Genmab /Solid tumors DuoBody-CD40x4-1BB CD40,50:50 Genmab /Solid tumors 2019 INDCD37GenmabHematological malignancies Daratumumab CD38Janssen (Tiered royalties toMultiple myeloma (MM)1 AL Amyloidosis Non-MM blood cancers Ofatumumab CD20Novartis (Royalties to GenmabChronic lymphocytic

PIPELINE PRODUCTS IN COLLABORATION Product Target Rights Disease Indications Most Advanced Development Phase Pre-clinical I I/II II III Launched (OMB157) (RV001) (under sublicense from Roche) (ADCT-301) Hodgkin lymphoma HuMab, DuoBody, DuoHexaBody preclinical programs 1 See local country prescribing information for precise indications. 2 Not in active clinical development. In 2019 the marketing authorization for Arzerra was withdrawn in the EU and several other territories. 3 Certain product candidates in development with partners, as noted. Management’s Review / Products in Development 23 Ofatumumab CD20Novartis Relapsing multiple sclerosis Teprotumumab IGF-1RHorizon Therapeutics Thyroid eye disease Camidanlumab tesirine CD25ADC Therapeutics Relapsed or refractory Solid tumors HuMax-IL8 IL8BMSAdvanced cancers JNJ-61186372EGFR, cMet JanssenNon-small-cell lung cancer (NSCLC) JNJ-63709178CD123, CD3JanssenAcute Myeloid Leukemia (AML) JNJ-64007957 BCMA, CD3Janssen Relapsed or refractory MM JNJ-64407564GPRC5D, CD3 Janssen Relapsed or refractory MM JNJ-67571244 CD33, CD3Janssen Relapsed or refractory AML or MDS JNJ-63898081 PSMA, CD3Janssen Solid tumors Lu AF82422alpha-Synuclein Lundbeck Parkinson’s disease ~20 active Partnered & proprietary programs: and HexaBody

Approved Products in Collaboration DARZALEX (daratumumab) is a human IgG1k mAb that binds with high affinity to the CD38 molecule, which is highly expressed on the surface of multiple myeloma cells. Daratu-mumab triggers a person’s own immune system to attack the cancer cells, resulting in rapid tumor cell death through multi-ple immune-mediated mechanisms of action and through immunomodulatory effects, in addition to direct tumor cell death, via apoptosis (programmed cell death). Daratumumab is being developed by Janssen under an exclusive worldwide license from Genmab to develop, manufacture and commer-cialize daratumumab (see Daratumumab Collaboration with Janssen Biotech, Inc. section for more information). DARZALEX (daratumumab) First CD38 Antibody Approved in the World DARZALEX (daratumumab) intravenous infusion is approved in certain territories for the treatment of adult patients with certain multiple myeloma indications as indicated on the following page. In short • First-in-class human CD38 antibody • Multiple Phase III studies ongoing in multiple myeloma including for a subcutaneous (SubQ) formulation, as well as a Phase III study in amyloid light-chain (AL) amyloidosis • Approved in combination with other therapies for frontline and for relapsed/refractory multiple my-eloma in territories including the U.S., Europe and Japan and as monotherapy for heavily pretreated or double-refractory multiple myeloma in territories including the U.S. and Europe • Early stage studies ongoing in other blood cancers • Collaboration with Janssen Biotech, Inc. (Janssen) • 2019 net sales of DARZALEX by Janssen were USD 2,998 million Management’s Review / DARZALEX 24

Jurisdiction Approval Key Underlying Clinical Trial(s) Jurisdiction Approval Key Underlying Clinical Trial(s) United States Relapsed / Refractory MM European Union Relapsed / Refractory MM November 2015 Monotherapy for patients who have received at least three prior lines of therapy, including a PI and an immunomodulatory agent, or who are double refractory to a PI and an immunomodulatory agent SIRIUS (MMY2002) April 2016 Monotherapy for patients whose prior therapy included a PI and an immunomodulatory agent and who have demonstrated disease progres-sion on the last therapy SIRIUS (MMY2002) February 2017 In combination with Rd or Vd for patients who have received at least one prior therapy CASTOR (MMY3004); POLLUX (MMY3003) November 2016 In combination with Rd or Vd, for patients who have received at least one prior therapy CASTOR (MMY3004); POLLUX (MMY3003) Frontline MM June 2017 In combination with Pom-d for pa-tients who have received at least two prior therapies, including lenalido-mide and a PI EQUULEUS (MMY1001) July 2018 In combination with VMP for newly diagnosed patients who are ineligi-ble for ASCT ALCYONE (MMY3007) November 2019 In combination with Rd for newly di-agnosed patients who are ineligible for ASCT MAIA (MMY3008) Frontline MM May 2018 In combination with VMP for newly diagnosed patients who are ineligi-ble for ASCT ALCYONE (MMY3007) Split Dosing Regimen June 2019 In combination with Rd for newly di-agnosed patients who are ineligible for ASCT MAIA (MMY3008) December 2018 Option to split first infusion over two consecutive days EQUULEUS (MMY1001) September 2019 In combination with VTd for newly diagnosed patients who are eligible for ASCT CASSIOPEIA (MMY3006) Japan Relapsed / Refractory MM September 2017 In combination with Rd or Vd CASTOR (MMY3004); POLLUX (MMY3003) Split Dosing Regimen February 2019 Option to split first infusion over two consecutive days EQUULEUS (MMY1001) Frontline MM August 2019 In combination with VMP for newly diagnosed patients ineligible for ASCT ALCYONE (MMY3007) December 2019 In combination with Rd for newly di-agnosed patients who are ineligible for ASCT MAIA (MMY3008) PI = proteasome inhibitor; Rd = lenalidomide and dexamethasone; Vd = bortezomib and dexamethasone; VMP = bortezomib, melphalan and prednisone; VTd = bortezomib, thalidomide and dexamethasone; ASCT = autolo-gous stem cell transplant; Pom-d = pomalidomide and dexamethasone Management’s Review / DARZALEX 25

About Multiple MyelomaAbout Amyloidosis No cure A blood cancer that occurs when malignant plas-ma cells grow uncontrollably in bone marrow and for which there is no cure at present. 26,000 52.2% Rare A very rare disease caused by the buildup of an abnormal protein called amyloid, which is made by plasma cells, in the tissues or organs. An estimated 16,000 people in the United States suffer from amyloidosis.4 12-15% of multiple myeloma patients develop light chain (AL) A comprehensive clinical development program for daratu-mumab is ongoing, including multiple Phase III studies in smoldering, maintenance and frontline multiple myeloma settings. Additional studies are ongoing or planned to assess the potential of daratumumab in other malignant and pre-malignant diseases in which CD38 is expressed, such as amyloidosis, NKT-cell lymphoma and T-cell acute lymphocytic leukemia (ALL). Daratumumab has received two Break-through Therapy Designations (BTD) from the U.S. FDA for certain indications of multiple myeloma, including as a monotherapy for heavily pretreated multiple myeloma and in combination with certain other therapies for second-line treatment of multiple myeloma. people estimated newly diagnosed with and 13,650 estima-ted to have died from multiple myeloma in the U.S. in 2018.2 160,000 people estimated diagnosed with and 106,000 estimated to have died from multiple myeloma worldwide in 2018.3 amyloidosis.5 3,000-4,000 approximate number of new cases diagnosed annually, making AL amyloidosis the most common type of amyloidosis in the U.S.4 Safety Information for DARZALEX The warnings and precautions for DARZALEX include infusion reactions, interference with serological testing and interfer-ence with determination of complete response. The most frequently reported adverse reactions (incidence 20%) in ≥ clinical trials were: infusion reactions, neutropenia, thrombo-cytopenia, fatigue, nausea, diarrhea, constipation, vomiting, muscle spasms, arthralgia, back pain, pyrexia, chills, dizzi-ness, insomnia, cough, dyspnea, peripheral edema, peripheral sensory neuropathy and upper respiratory tract infection. Sources: 1 Surveillance, Epidemiology and End Results Program (SEER). Cancer Stat Facts: Myeloma. Available at http://seer.cancer.gov/statfacts/html/ mulmy.html. Accessed November 2019. 2 Globocan 2018. United States of America Fact Sheet. Available at http://gco.iarc.fr/today/data/factsheets/populations/840-unit-ed-states-of-america-fact-sheets.pdf. Accessed December 2019. 3 Globocan 2018. World Fact Sheet. Available at http://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf. Accessed December 2019. 4 Research and Markets, “Amyloidosis Treatment Market Size, Share & Trends Analysis Report by Treatment (Stem Cell Transplant, Chemotherapy, Supportive Care, Surgery, Targeted Therapy), By Country, And Segment Forecasts, 2018 – 2025. 5 Cancer.Net Guide to Amyloidosis. https://www.cancer.net/cancer-types/amyloidosis/risk-factors Accessed December 2019. Please consult the full U.S. Prescribing Information and the full European Summary of Product Characteristics for all the labeled safety information for DARZALEX. Fourth Quarter Updates December: In January 2020 Janssen confirmed that Genmab had achieved a USD 150 million sales volume milestone

payment triggered by sales of DARZALEX reaching USD 3 billion in the calendar year of 2019 as calculated on the basis of the license agreement terms. Under Genmab’s license agreement with Janssen, DARZALEX sales are calculated based on a hedged foreign exchange rate and as such are different than net trade sales reported by Johnson & Johnson. The difference was mainly due to the translation of sales denominated in curren-cies other than USD into USD under the license agreement. November: The European Commission approved DARZALEX in combination with Rd as treatment for adult patients with newly diagnosed multiple myeloma who are ineligible for ASCT. The approval followed issuance of a positive opinion from the CHMP in October. The Type II Variation was submit-ted for approval to the European Medicines Agency (EMA) in March. progression free survival (PFS). Daratumumab in combination with Kd resulted in a 37% reduction in the risk of progression or death in patients with relapsed or refractory multiple myeloma (HR=0.630; 95% CI: 0.464, 0.854; p=0.0014). The median PFS for patients treated with daratumumab in combination with Kd had not been reached by the cut-off date compared to a median PFS of 15.8 months for patients who received Kd alone. There was a higher frequency of adverse events reported with daratumumab plus Kd, a three-agent regimen, than with Kd, a two-agent regimen. The types of observed adverse events were consistent with the known safety profiles of the individual agents. Enrollment complete in the Phase III PERSEUS (MMY3014) study of daratumumab in combination with bortezomib, lenalidomide and dexamethasone (VRd) in patients with previously untreated multiple myeloma who are eligible for high-dose therapy. A Supplemental new drug application (sNDA) was approved by the Ministry of Health, Labor and Welfare (MHLW) in Japan for daratumumab in combination with Rd as a treatment for pa-tients newly diagnosed with multiple myeloma who are ineligi-ble for ASCT. The sNDA was submitted to the MHLW in April. Genmab achieved a milestone payment following the approval. August: DARZALEX was approved in combination with VMP for the treatment of patients with newly diagnosed multiple myeloma who are ineligible for ASCT in Japan. Genmab achieved a USD 7 million milestone payment. Updates from First Quarter to Third Quarter The European Committee for Medicinal Products for Human Use (CHMP) issued a positive opinion recommending DARZALEX in combination with VTd as treatment for patients newly diagnosed with multiple myeloma who are eligible for ASCT. The Type II Variation was submitted for approval to the European Medicines Agency (EMA) in March. September: DARZALEX approved in the U.S. in combination with VTd as treatment for patients newly diagnosed with multiple myeloma who are eligible for autologous stem cell transplant (ASCT). The approval followed issuance of a Priority Review from the U.S. FDA in May. The supplemental Biologics License Application (sBLA) was submitted for approval to the U.S. FDA in March. July: A Biologics License Application (BLA) was submitted to the U.S. FDA and an extension of the marketing authorization was submitted to the European Medicines Agency for the SubQ formulation of daratumumab. In September the BLA received a standard review from the U.S. FDA. Updated data from the Phase III ALCYONE (MMY3007) study of daratumumab in combination with VMP for the treatment of patients with newly diagnosed multiple myeloma who are ineligible for ASCT was published in The Lancet, volume 395, issue 10218, p132-141. Recruitment complete in the Phase III CEPHEUS (MMY3019) study of SubQ daratumumab in combination with VRd in patients with untreated multiple myeloma for whom hemato-poietic stem cell transplant is not planned as initial therapy. The Phase II GRIFFIN (MMY2004) study of daratumumab in combination with VRd versus VRd alone for transplant eligible patients with newly diagnosed multiple myeloma met the primary endpoint of stringent complete response (sCR). The topline data showed that 42.4% of patients treated with daratumumab in combination with VRd achieved a sCR, compared to 32.0% of patients who received VRd alone, with an odds ratio of 1.57 (95% CI: 0.87 – 2.82, p=0.1359, exceeding the statistical significance at the pre-set 2-sided Janssen confirmed that DARZALEX net sales hit the USD 2.5 billion mark during 2019, which triggered a USD 100 million milestone payment to Genmab from Janssen under the companies’ collaboration. Topline results from the Phase III CANDOR study, sponsored by Amgen, of daratumumab in combination with carfilzomib and dexamethasone (Kd) versus Kd alone in relapsed or refractory multiple myeloma met the primary endpoint of improvement in Management’s Review / DARZALEX 27

alpha level of 0.2). Secondary endpoints, including the results of the minimal residual disease (MRD) analysis, supported the primary endpoint favoring daratumumab in combination with VRd. Overall, the safety profile of daratu-mumab in combination with VRd was consistent with the safety profile for each therapy separately. relapsed or refractory multiple myeloma were reported. The results showed that SubQ administration of daratumumab co-formulated with recombinant human hyaluronidase PH20 is non-inferior to IV administration of daratumumab with regard to the co-primary endpoints of overall response rate (ORR) and Maximum Trough concentration (Ctrough) of daratumumab on day 1 of the third treatment cycle. The ORR for patients treated with SubQ daratumumab was 41.1% versus 37.1% in patients treated with IV daratumumab. The lower limit of the 95% Confidence Interval (CI) for the ratio of the two met the specified non-inferiority criterion for this co-primary endpoint. The geometric mean of Ctrough for patients treated with SubQ daratumumab was 499 mg/mL versus 463 mg/mL in patients treated with IV daratumumab. The lower limit of the 95% CI for the ratio of the two met the specified non-inferiority criterion for this co-primary endpoint. No new safety signals were detected. The U.S. FDA approved an update to the Prescribing Informa-tion for DARZALEX to provide healthcare professionals the option to split the first infusion of DARZALEX over two consecutive days. DARZALEX was approved as monotherapy in China for adult patients with relapsed or refractory multiple myeloma. June: The U.S. FDA approved the use of DARZALEX in combination with Rd for the treatment of adult patients newly diagnosed with multiple myeloma who are ineligible for ASCT. The sBLA was submitted in March and the U.S. FDA reviewed the application for approval of this sBLA under their RTOR pilot program. April: The Phase III AURIGA (MMY3021) study was announced to examine daratumumab plus lenalidomide as maintenance treatment in patients with newly diagnosed multiple myeloma and utilizes the SubQ formulation of daratumumab. The first patient was dosed in June with enrollment put on a temporarily hold in September due to a U.S. FDA request for additional information related to analytical methods included in the study protocol. March: The Phase II LYNX (MMY2065) study of SubQ daratu-mumab in combination with Kd compared to Kd in patients with relapsed refractory multiple myeloma who were previously treated with intravenous (IV) daratumumab was published on www.clinicaltrials.gov. February: Topline results from the Phase III COLUMBA study (MMY3012) of SubQ versus IV daratumumab for patients with Management’s Review / DARZALEX 28 Daratumumab Collaboration with Janssen Biotech, Inc. In 2012, Genmab and Janssen Biotech, Inc., one of thereceive up to USD 180 million in further payments if Janssen Pharmaceutical Companies of Johnson & Johnson, certain additional milestones are met. entered a global license and development agreement for daratumumab. Genmab received an upfront license feeThe following royalty tiers apply for net sales in a calendar of USD 55 million and Johnson & Johnson Developmentyear: 12% on net sales up to USD 750 million; 13% on net Corporation (JJDC) invested USD 80 million to subscribesales between USD 750 million and USD 1.5 billion; 16% for 5.4 million new Genmab shares. Genmab could also be on net sales between USD 1.5 billion and USD 2.0 billion; entitled to up to USD 1,015 million in development, reg-18% on net sales between USD 2.0 billion and USD 3.0 ulatory and sales milestones, in addition to tiered doublebillion; and 20% on net sales exceeding USD 3.0 billion. digit royalties between 12% and 20%.Janssen is fully responsible for developing and commer-cializing daratumumab and all costs associated therewith. To date Genmab has recorded USD 835 million in mile-stone payments from Janssen and could be entitled to

Daratumumab Development Covering All Stages Of Multiple Myeloma – Key Ongoing Trials Disease Stage Therapy Development Phase Pre-clinical I I/II II III High Risk Smoldering Monotherapy Monotherapy Front line (transplant & non-transplant) Dara + VMP Dara + VMP (Asia Pacific) Dara + Rd Dara + VRd Dara + VTd Dara + VRd Dara + R (maintenance) Dara + VRd Relapsed or Refractory Dara + Vd (China) Dara + Kd Dara + Pom + d Subcutaneous vs IV V = Velcade® , MP = melphalan-prednisone , T = thalidomide d= dexamethasone, R = Revlilmid®, K = Kyprolis®, Pom = Pomalyst®, Fully recruited Dara + combinations NINLARO® (Ph II), Venclexta® (Ph II), Selinexor (Ph I/II) Dara + I.O. (PD1 & PDL1) Opdivo® (Ph I/II), Tecentriq® (Ph I) Daratumumab Development: Beyond Multiple Myeloma Disease Stage Therapy Development Phase Pre-clinical I I/II II III AL Amyloidosis Dara + CyBorD ALL Dara + SoC chemo CyBorD = cyclophosphamide, bortezomib and dexamethasone, SoC = standard of care, Fully recruited NKTCL (nasal type) Dara monotherapy Management’s Review / DARZALEX 29 ANDROMEDA DELPHINUS VOLANS AQUILA CENTAURUS ALCYONE OCTANS MAIA CEPHEUS CASSIOPEIA PERSEUS AURIGA GRIFFIN LEPUS CANDOR APOLLO COLUMBA

Arzerra (ofatumumab) First Genmab Created Product on the Market Arzerra (ofatumumab) is a human IgG1k mAb that targets an epitope on the CD20 molecule encompassing parts of the small and large extracellular loops. It is commercialized by Novartis under a license agreement between Genmab and Novartis Pharma AG (see Ofatumumab Collaboration with Novartis Pharma AG section for more information). In the U.S., Arzerra solution for infusion is approved for use in combination with chlorambucil for the treatment of previously untreated patients with CLL for whom fludara-bine-based therapy is considered inappropriate; for use in combination with fludarabine and cyclophosphamide (FC) for the treatment of patients with relapsed CLL; and for extended treatment of patients who are in complete or partial response after at least two lines of therapy for recurrent or progressive CLL. It is also indicated as monotherapy for the treatment of patients with CLL who are refractory to fludarabine and alemtuzumab. In 2019, the marketing authorization for Arzerra was withdrawn in the EU and several other territories. Arzerra is commercially available in Japan as well as in the U.S. and certain other territories. In Short • Human CD20 monoclonal antibody commercialized by Novartis under a license agreement with Genmab • Arzerra is available for certain CLL indications in the U.S., Japan and certain other territories • 2019 net sales of Arzerra by Novartis were USD 17 million Safety Information for Arzerra The overall safety profile of Arzerra in CLL is based on ex-posure in clinical trials and the post-marketing setting. The most common side effects for Arzerra include adverse events associated with infusion reactions, cytopenias, and infec-tions (lower respiratory tract infection, including pneumonia, upper respiratory tract infection, sepsis, including neutrope-nic sepsis and septic shock, herpes viral infection, urinary tract infection). Management’s Review /Arzerra 30

Please consult the full U.S. Prescribing information, includ-ing Boxed Warning for all the labeled safety information for Arzerra. Update from First Quarter to Third Quarter February: The marketing authorization for Arzerra was with-drawn in the EU and several other territories. Management’s Review / Arzerra 31 Ofatumumab Collaboration with Novartis Pharma AG (Novartis) Genmab and GlaxoSmithKline (GSK) entered a co-development and collaboration agreement for ofatu-mumab in 2006. The full rights to ofatumumab were transferred from GSK to Novartis in 2015. Novartis is now responsible for the development and commer-cialization of ofatumumab in all potential indications, including cancer and autoimmune diseases. Genmab is entitled to a 20% royalty payment of net oncology sales and to a 10% royalty payment of net sales for non-cancer treatments. Novartis is fully responsible for all costs associated with developing and com-mercializing ofatumumab. Please see page 39 for information about the development of ofatumumab in multiple sclerosis.

Proprietary Products in Development Tisotumab vedotin is an ADC targeted to tissue factor (TF), a protein involved in tumor signaling and angiogenesis. Based on its high expression on many solid tumors and its rapid internalization, TF is a suitable target for an ADC approach. Ti-sotumab vedotin is in clinical development for solid tumors. Tisotumab vedotin is being co-developed by Genmab and Se-attle Genetics, under an agreement in which the companies share all costs and profits for the product on a 50:50 basis. Tisotumab vedotin A Next Generation Therapeutic Fourth Quarter Updates December: Data from the innovaTV 201 study was published in Clinical Cancer Research, published online, December 3, 2019. innovaTV 205 trial updated to include an arm with weekly monotherapy treatment. Updates from First Quarter to Third Quarter August: Expansion phase initiated in innovaTV 206 study of tisotumab vedotin as monotherapy for patients in Japan with recurrent and/or metastatic cervical cancer. In Short • Antibody-drug conjugate (ADC), an antibody cou-pled to a cell-killing agent, in development to treat solid tumors • Co-developed under a license and collaboration agreement with Seattle Genetics March: First patient was dosed in the Phase I/II innovaTV 206 study of tisotumab vedotin as monotherapy for patients in Japan with recurrent and/or metastatic cervical cancer. • Phase II potential registration study in cervical cancer ongoing, enrollment completed; Phase II clinical studies in ovarian and other solid tumors ongoing Patient enrollment was completed in the potential registra-tion Phase II innovaTV 204 study of tisotumab vedotin as a monotherapy for patients with recurrent and/or metastatic cervical cancer who have relapsed or progressed after stan-dard of care treatment. Management’s Review / Tisotumab vedotin 32

About Cervical Cancer1 Cancer Key Trials that originates in the cells lin-ing the cervix. Disease Stage Development Phase Pre-clinical I I/II II III 65.8% Cervical cancer Recurrent or metastatic 5-year survival rate in the U.S.2 Recurrent or Stage IVB (combo & mono) Ovarian cancer Platinum resistant Solid tumors Locally advanced or metastatic Locally advanced or metastatic (Japan) 570,000 women estimated diagnosed with and 311,000 estimated to have died from cervical cancer in 2018, the vast majority in the developing world.3 Locally advanced or metastatic Fully recruited 13,170 women estimated diagnosed with and 4,250 estimated to have died from cervical cancer in the U.S. in 2019.2 Sources: 1 Statistics include all stages of cervical cancer. Tisotumab vedotin is in clinical trials for recurrent or metastatic cervical cancer. 2 National Cancer Institute SEER. “Cancer Stat Facts: Cervical Cancer.” Available at https://seer.cancer.gov/statfacts/html/cervix.html. Accessed December 2019. 3 Globocan 2018. World Fact Sheet. Available at http://gco.iarc.fr/ today/data/factsheets/populations/900-world-fact-sheets.pdf. Accessed December 2019. Management’s Review / Tisotumab vedotin 33 Tisotumab vedotin Collaboration with Seattle Genetics, Inc. In September 2010, Genmab and Seattle Genetics,In August 2017, Seattle Genetics exercised its Inc. entered into an ADC collaboration, and aoption to co-develop and co-commercialize commercial license and collaboration agreementtisotumab vedotin with Genmab. Under the was executed in October 2011. Under the agree-agreement, Seattle Genetics and Genmab will each ment, Genmab was granted rights to utilize Seattlebe responsible for leading tisotumab vedotin Genetics’ ADC technology with its human monoclo-commercialization activities in certain territories. nal TF antibody. Seattle Genetics was grantedThe companies are in discussions regarding the rights to exercise a co-development and co-com-terms on which we will work together to commer-mercialization option at the end of Phase I clinical cialize tisotumab vedotin. All costs and profits for development for tisotumab vedotin.tisotumab vedotin will be shared on a 50:50 basis. innovaTV 204 innovaTV 205 innovaTV 208 innovaTV 207 innovaTV 206 innovaTV 201

EAnFairpsot-tianm-CalabsvseAdDoCtin Targeting AXL Enapotamab vedotin is an ADC targeted to AXL, a signaling molecule expressed on many solid cancers and implicated in tumor biology. Enapotamab vedotin is fully owned by Genmab and the ADC technology used with enapotamab vedotin was licensed from Seattle Genetics. A Phase I/II clinical study of enapotamab vedotin for multiple types of solid tumors is ongoing. In Short Update from First Quarter to Third Quarter September: Preliminary data from the non-small cell lung cancer (NSCLC) expansion cohort of the Phase I/II study of enapotamab vedotin in solid tumors was presented during an oral session at the International Association for the Study of Lung Cancer 2019 World Conference on Lung Cancer (IASLC 2019 WCLC). • ADC in development to treat solid tumors • Phase I/II clinical study for multiple solid tumors ongoing Enapotamab Vedotin ADC Technology License from Seattle Genetics, Inc. In September 2014, Genmab entered into an ADC agreement with Seattle Genetics. Under this agreement, Genmab paid an upfront fee of USD 11 million for exclusive rights to utilize Seattle Genetics’ ADC technology with Genmab’s human monoclonal AXL antibody. Seattle Genetics is also entitled to receive more than USD 200 million in potential milestone payments and mid-to-high single digit royalties on worldwide net sales of any resulting products. In addition, prior to Genmab’s initiation of a Phase III study for any resulting products, Seattle Genetics has the right to exercise an option to increase the royalties to the low tens in exchange for a reduction of the milestone payments owed by Genmab. Irrespective of any exercise of option, Genmab remains in full control of development and commercialization of any resulting products. Management’s Review / Enapotamab vedotin 34

HexaBody-DR5/DR5 Epcoritamab (FGirEstNH1e0x2a9B)ody Program in Clinical Development (ADPurooBporideyta-CryD3xCD20) Bispecific Antibody HexaBody-DR5/DR5 (GEN1029) is a product comprising a mixture of two non-competing HexaBody antibody mole-cules that target two distinct epitopes on death receptor 5 (DR5), a cell surface receptor that mediates a process called programmed cell death. Increased expression of DR5 has been reported in several types of tumors. A Phase I/II clinical trial in solid tumors is ongoing. Epcoritamab (DuoBody-CD3xCD20) is a proprietary bispecific antibody created using Genmab’s DuoBody technology. Epcoritamab targets CD3, which is expressed on T-cells, and CD20, a clinically well-validated target. A Phase I/II clinical study of a SubQ formulation of epcoritamab in B-cell malignancies is ongoing. In Short • Proprietary antibody therapeutic created with Genmab’s HexaBody technology In Short • Proprietary bispecific antibody created with Genmab’s DuoBody technology Fourth Quarter update • Composed of two non-competing HexaBody antibody molecules that target two distinct DR5 epitopes • Phase I/II clinical trial in B-cell malignancies ongoing Update from First Quarter to Third Quarter December: Initial dose-escalation data from the Phase I/II clinical trial was presented during an oral session of the 61st American Society of Hematology (ASH) Annual Meeting. August: The Phase I/II clinical trial was put on a brief partial clinical hold for discussions with the U.S. FDA around liver toxicity. After the protocol was amended with additional provisions to mitigate liver toxicity risk the partial hold was lifted in October and enrollment of patients was re-opened. • Phase I/II clinical trial in solid tumors ongoing Management’s Review / HexaBody-DR5/DR5 / Epcoritamab (DuoBody-CD3xCD20) 35

DuoBody-PD-L1x4-1BB (BGisEpNe1c0ifi4c6N) ext Generation Checkpoint Immunotherapy DuoBody-CD40x4-1BB (PGoEteNn1t0ia4l2F)irst-in-Class Bispecific Agonistic Antibody DuoBody-PD-L1x4-1BB (GEN1046) is a proprietary bispe-cific antibody, jointly owned by Genmab and BioNTech, created using Genmab’s DuoBody technology. It is being co-developed by Genmab and BioNTech under an agree-ment in which the companies share all costs and profits for the product on a 50:50 basis. DuoBody-PD-L1x4-1BB targets PD-L1 and 4-1BB, selected to block inhibitory PD-1 / PD-L1 axis and simultaneously activate essential co-stim-ulatory activity via 4-1BB using inert DuoBody antibody format. A Phase I/II clinical study of DuoBody-PD-L1x4-1BB in solid tumors is ongoing. DuoBody-CD40x4-1BB (GEN1042) is a proprietary bispe-cific antibody, jointly owned by Genmab and BioNTech, created using Genmab’s DuoBody technology. It is being co-developed by Genmab and BioNTech under an agree-ment in which the companies share all costs and profits for the product on a 50:50 basis. CD40 and 4-1BB were selected as targets to enhance both dendritic cells (DC) and antigen-dependent T-cell activation, using an inert DuoBody format. A Phase I/II clinical study of DuoBody-CD40x4-1BB in solid tumors is ongoing. In Short • Bispecific antibody created with Genmab’s DuoBody technology In Short • Bispecific antibody created with Genmab’s DuoBody technology • Phase I/II clinical trial in solid tumors ongoing • Phase I/II clinical trial in solid tumors ongoing • Developed in collabo-ration with BioNTech • Developed in collabo-ration with BioNTech Updates from First Quarter to Third Quarter Updates from First Quarter to Third Quarter September: First patient dosed in the first-in-human Phase I/ II trial of DuoBody-CD40x4-1BB in solid tumors. May: First patient dosed in the first-in-human Phase I/II trial of DuoBody-PD-L1x4-1BB in solid tumors. March: A CTA for DuoBody-CD40x4-1BB was submitted to regulatory authorities in the UK. January: A CTA for DuoBody-PD-L1x4-1BB was submitted to regulatory authorities in Spain. Management’s Review / DuoBody-PD-L1x4-1BB / DuoBody-CD40x4-1BB 36

Management’s Review 37

Partner Programs Built on Genmab’s Innovation In addition to our two approved products in collaboration and six proprietary clinical projects, our collaboration partners are running clinical development programs with antibodies created by Genmab or created using our DuoBody bispecific antibody technology. Management’s Review / Partner Programs 38

Ofatumumab (OMB157) About Multiple Sclerosis Ofatumumab is a human IgG1k mAb that targets an epitope on the CD20 molecule encompassing parts of the small and large extracellular loops. It is developed by No-vartis under a license agreement between Genmab and Novartis Pharma AG (see Ofatumumab Collaboration with Novartis Pharma AG section for more information). A SubQ formulation of ofatumumab was investigated in two Phase III clinical studies in RMS. The studies compared the efficacy and safety of SubQ ofatumumab versus teriflunomide in patients with RMS and were comprised of approximately 900 patients each. A Phase III study examining the long-term safety, tolerability and effec-tiveness of ofatumumab in patients with RMS who participated in a previous study is ongoing as is a study to evaluate the bio-equivalence of 20mg of SubQ ofatumumab injected by either pre-filled syringe or auto-injector in adult relapsing MS patients. mumab versus teriflunomide in adults with relapsing forms of multiple sclerosis met the primary endpoints where ofatumumab showed a highly significant and clinically meaningful reduction in the number of confirmed relapses, evaluated as the an-nualized relapse rate (ARR). Key secondary endpoints including delaying the time to confirmed disability progression were also met. According to Novartis, ofatumumab delivered sustained efficacy and the safety profile of ofatumumab as seen in the AS-CLEPIOS studies is in line with the obser-vations from prior Phase II results. Detailed data from these studies was subsequently presented at the 35th Congress of the Euro-pean Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) in Septem-ber. Patients with RMS on ofatumumab had a reduction in ARR by 50.5% (0.11 vs. 0.22) and 58.5% (0.10 vs 0.25) compared to teriflunomide (both studies p<0.001) in ASCLEPIOS I & II studies respectively. Regarding secondary endpoints of the trials, ofatumumab showed highly significant suppression of gadolinium (Gd) enhancing T1 lesions when compared to teriflunomide demonstrating a profound suppression of new inflammatory activity. Ofatumumab showed a relative risk reduction of 34.4% in 3-month confirmed disability worsening (CDW) (p=0.002) and 32.5% in 6-month CDW (p=0.012) versus teriflunomide in pre-specified pooled analyses. In Short • Human CD20 monoclonal antibody developed by Novartis under a license agreement with Genmab Chronic 85% disorder of the central nervous system that disrupts the normal functioning of the brain, optic nerves and spinal cord through inflam-mation and tissue loss. of MS cases are relapsing remitting multiple sclerosis (RRMS), characterized by unpredictable recurrent attacks.1 • Subcutaneous formula-tion in development to treat relapsing multiple sclerosis (RMS) 2.5M people affected worldwide.2 53,299 diagnosed incident cases MS in 2019 in the U.S., Japan and 5 major EU markets.3 • Positive data available from the two Phase III ASCLEPIOS studies with SubQ ofatumumab in RMS • Based on ASCLEPIOS data Novartis initiated submission to U.S. health authorities in 2019 Fourth Quarter Update December: Novartis initiated submission of an sBLA to U.S. health authorities seeking approval of the subcutaneous formulation of ofatumumab. Sources: 1 Datamonitor. Multiple Sclerosis Treatment. Published August 2016. 2 GlobalData. EpiCast Report: Multiple Sclerosis – Epidemiology Forecast to 2026. Published November 2017. 3 GlobalData. Multiple Sclerosis: Epidemiology Forecast to 2028. Published November 2019 Update from First Quarter to Third Quarter August: Novartis reported that the Phase III ASCLEPIOS I & II studies of SubQ ofatu-Management’s Review / Partner Programs 39

Teprotumumab About Thyroid Eye Disease (TED) Teprotumumab, approved by the U.S. FDA in January 2020 under the trade name TEPEZZA™, is a fully human antibody that targets the Insulin-like Growth Factor-1 Re-ceptor, a well-validated target. TEPEZZA was developed and is manufactured by Horizon. Horizon submitted the BLA for TEPEZZA, which received Priority Review, Orphan Drug, Fast Track and Breakthrough Therapy desig-nations from the U.S. FDA for the treatment of TED. The medicine was created by Genmab under a collaboration with Roche and devel-opment of the product is now being conduct-ed by Horizon under a license from Roche. Under the terms of Genmab’s agreement with Roche, Genmab will receive mid-single digit royalties on sales of TEPEZZA. In Short • Developed and man-ufactured by Horizon Therapeutics, plc (Horizon) for thyroid eye disease (TED) Updates from First Quarter to Third Quarter Vision-threatening September: U.S. FDA granted Priority Review to the BLA submitted by Horizon for tepro-tumumab in the treatment of active TED. The U.S. FDA assigned a Prescription Drug User Fee Act (PDUFA) target date of March 8, 2020 to take a decision on the BLA for teprotumumab. The BLA was submitted to the U.S. FDA in July. Rare, progressive and vision-threatening autoimmune disease1 Associated with thyroid disease, affecting the ocular and orbital tissues 1 50 % Misalignment of the eyes (strabismus) and double vision (diplopia) are reported in about 50% of people with TED2 • In 2019 a BLA submit-ted to the U.S. FDA by Horizon for teprotu-mumab in active TED received Priority Review February: Topline results from the Phase III confirmatory trial evaluating teprotumum-ab for the treatment of active thyroid eye disease showed that the study met its primary endpoint. Annual incidence is approximately 3 out of 100,000 men and 16 out of 100,000 women3 HuMax-IL8 HuMax-IL8 is a high affinity fully human an-tibody directed towards IL-8. IL-8 has been shown to be involved in several aspects of tumor development including tumor spread (metastasis), cancer stem cell renewal and tumor immune-suppression. HuMax-IL8 has been shown to inhibit these processes and to inhibit tumor growth in pre-clinical tumor models. HuMax-IL8 is in development for the treatment advanced cancers under an agreement with Bristol-Myers Squibb. In Short • Human antibody in devel-opment by Bristol-Myers Squibb (BMS-986253) Sources: 1 Barrio-Barrio J, et al. Graves’ Ophthalmopathy: VISA versus EUGOGO Classification, Assessment, and Man-agement. Journal of Ophthalmopathy. 2015;2015:1-16. 2 Horizon Therapeutics, Understanding Thyroid Eye Disease (TED), https://www.horizontherapeutics.com/ PDFs/TED_fact_sheet.pdf, Accessed February 2020 3 Bahn RS. Graves’ ophthalmopathy. N Engl J Med. 2010;362:726-738 • In Phase I/II development in advanced cancers Management’s Review / Partner Programs 40

Camidanlumab tesirine (ADCT-301) JNJ-61186372 JNJ-63709178 In Short • ADC in development under a collaboration and license agreement with ADC Therapeutics In Short • DuoBody product targeting EGFR and cMET In Short • DuoBody product targeting CD123 and CD3 • Phase I and I/II studies ongoing in NSCLC • Phase I study in relapsed or refractory AML • In development for Hodgkin lymphoma and solid tumors • Developed by Janssen under the DuoBody technology collaboration • Developed by Janssen under the DuoBody technology collaboration Camidanlumab tesirine is an ADC that combines Genmab’s HuMax-TAC antibody and ADC Therapeu-tics’ PBD-based warhead and linker technology. Camidanlumab tesirine targets CD25, which is expressed on a variety of hematological tumors and shows limited expression on normal tissues, except for regulatory T cells, which are known to be immunosuppressive. This makes CD25 an attrac-tive target for antibody-payload approaches in he-matological and solid tumors. Camidanlumab tesir-ine is in clinical development under a Collaboration and License Agreement between Genmab and ADC Therapeutics, under which Genmab owns 25% of the product rights. A Phase II study of camidanlum-ab tesirine to treat relapsed or refractory Hodgkin lymphoma and a Phase I study of camidanlumab tesirine to treat solid tumors are ongoing. JNJ-61186372 is a bispecific antibody that targets EGFR and cMET, two validated cancer targets. JNJ-61186372 was created under a collaboration be-tween Genmab and Janssen using Genmab’s Duo-Body technology. The two antibodies used to gen-erate JNJ-61186372 were both created by Genmab. Janssen is investigating JNJ-61186372 in Phase I and I/II clinical studies for the treatment of NSCLC. JNJ-63709178 is a bispecific antibody that targets CD3, which is expressed on T-cells, and CD123, which is overexpressed in various hema-tologic malignancies. JNJ-63709178 may redirect T-cells, resulting in T-cell mediated killing of CD123+ acute myeloid leukemia (AML) cells. JNJ-63709178 was created by Janssen using Genmab’s DuoBody technology. JNJ-63709178 is being investigated in a Phase I clinical study for the treatment of AML. Fourth Quarter Update October: Genmab achieved a milestone payment for progress with the program. Updates from First Quarter to Third Quarter September: A Phase I study in combination with lazertinib in Japanese patients with advanced NSCLC published on www.clinicaltrials.gov. Update from First Quarter to Third Quarter August: A Phase II trial of camidanlumab tesirine in patients with relapsed or refractory Hodgkin lymphoma was published on www.clinicaltrials.gov. June: Updated data from Phase I study in NSCLC presented in an oral session at 2019 ASCO Annual Meeting. Management’s Review / Partner Programs 41

JNJ-64007957 JNJ-64407564 JNJ-67571244 In Short • DuoBody product targeting BCMA and CD3 In Short • DuoBody product targeting CD3 and GPRC5D In Short • DuoBody product targeting CD33 and CD3 • Phase I studies in multiple myeloma an-nounced and ongoing • Phase I studies in multiple myeloma announced and ongoing • In Phase I study for relapsed or refractory AML or MDS • Developed by Janssen under the DuoBody technology collaboration • Developed by Janssen under the DuoBody technology collaboration • Developed by Janssen under the DuoBody technology collaboration JNJ-64007957 is a bispecific antibody that targets BCMA, which is expressed in mature B lymphocytes, and CD3, which is expressed on T-cells. JNJ-64007957 was created by Janssen using Genmab’s DuoBody technology. JNJ-64007957 is being investigated in Phase I clinical studies for the treatment of multiple myeloma. JNJ-64407564 is a bispecific antibody that targets CD3, which is expressed on T-cells, and GPRC5D, which is highly expressed on multiple myeloma cells. JNJ-64407564 was created by Janssen using Genmab’s DuoBody technology. JNJ-64407564 is being investigated in Phase I clinical studies for the treatment of multiple myeloma. JNJ-67571244 is a bispecific antibody that targets CD3, which is expressed on T-cells and CD33, which is frequently expressed in AML and myelodysplastic syndrome (MDS). JNJ-67571244 was created under a collaboration between Genmab and Janssen using Genmab’s DuoBody technology. JNJ-67571244 is being investigated in a Phase I clinical study to treat relapsed or refractory AML or MDS. Update from First Quarter to Third Quarter Update from First Quarter to Third Quarter Updates from First Quarter to Third Quarter September: Phase Ib trial (MMY1002) of SubQ daratumumab in combination with either JNJ-64407564 or JNJ-64007957 for patients with multiple myeloma published on www.clinicaltrials.gov. September: Phase Ib trial (MMY1002) of SubQ daratumumab in combination with either JNJ-64407564 or JNJ-64007957 for patients with multiple myeloma published on www.clinicaltrials.gov. July: Genmab achieved a milestone payment for progress with the program. May: A Phase I study of JNJ-67571244 in re-lapsed or refractory AML or MDS was initiated. Management’s Review / Partner Programs 42

JNJ-63898081 Lu AF82422 Pre-clinical Programs In Short • DuoBody product targeting PSMA and CD3 In Short • Human antibody targeting alpha-synuclein In Short • Broad pre-clinical pipeline of approximately 20 programs including DuoHexaBody-CD37, HexaBody-CD38 and DuoBody-CD3x5T4 • In Phase I study for advanced solid tumors • Phase I study in healthy volunteers and patients with Parkinson’s disease • Developed by Janssen under the DuoBody technology collaboration • Pre-clinical pipeline includes both partnered products and in-house programs based on our proprietary technologies • Developed under a collaboration with Lundbeck • Multiple new Investigational New Drug Applications (INDs) expected to be submitted over coming years JNJ-63898081 is a bispecific antibody that tar-gets CD3, which is expressed on T-cells and pros-tate-specific membrane antigen (PSMA), which is highly expressed on prostate adenocarcinomas. JNJ-63898081 was created under a collaboration between Genmab and Janssen using Genmab’s DuoBody technology. JNJ-63898081 is being investigated in a Phase I clinical study to treat advanced solid tumors. Lu AF82422 is a human antibody that targets alpha-synuclein, a protein that is linked to Parkinson’s disease. Lu AF82422 targets the un-derlying biology of Parkinson’s disease and aims to treat the disease by slowing or stopping the disease progression. Lu AF82422 was invented by Lundbeck in collaboration with Genmab. Lu AF82422 is being investigated in a Phase I clini-cal study in both healthy volunteers and patients with Parkinson’s disease. • In 2019 entered multiple strategic collaborations to support the expansion of Genmab’s innovative pipeline Our pre-clinical pipeline includes naked antibodies, immune effector function enhanced antibodies de-veloped with our HexaBody technology, and bispe-cific antibodies created with our DuoBody platform. A number of the pre-clinical programs are carried out in cooperation with our collaboration partners. Updates from First Quarter to Third Quarter July: Genmab achieved a milestone payment for progress with the program. April: A Phase I study of JNJ-63898081 in ad-vanced solid tumors was published on www.clinicaltrials.gov. Fourth Quarter Updates December: Entered into a strategic partnership with CureVac AG that will combine CureVac’s mRNA technology and know-how with Genmab’s propri-etary antibody technologies and expertise in order to develop differentiated mRNA-based antibody products. Management’s Review / Partner Programs 43

Under the terms of the agreement Genmab will provide CureVac with a USD 10 million upfront payment. Genmab will also make a EUR 20 million equity investment in CureVac. The companies will collaborate on research to identify an initial product candidate and CureVac will contribute a portion of the overall costs for the development of this product candidate, up to the time of an IND. Genmab would thereafter be fully responsible for the development and commercialization of the potential product, in exchange for undisclosed milestones and tiered royalties to CureVac. The agreement also includes three additional options for Genmab to obtain commercial licenses to CureVac’s mRNA technology at pre-defined terms, exercisable within a five-year period. If Genmab exercises any of these options, it would fund all research and would develop and commercialize any resulting product candidates with CureVac eligible to receive between USD 275 million and USD 368 million in development, regulatory and commercial milestone payments for each product, dependent on the specific product concept. In addition, CureVac is eligible to receive tiered royalties in the range from mid-single digits up to low double digits per product. CureVac would retain an option to participate in development and/or commercializa-tion of one of the potential additional programs under pre-defined terms and conditions. antibody product incorporating Genmab’s HexaBody technology. Genmab will fund research and development activities until completion of clinical proof of concept studies in multiple myeloma and diffuse large B-cell lymphoma. Based on the data from these studies, Janssen may exercise its option and receive a worldwide license to develop, manufacture and commercialize HexaBody-CD38. Should this occur, Janssen will pay Genmab a USD 150 million option exercise fee and up to USD 125 million in development milestones, as well as a flat royalty rate of 20% on sales of HexaBody-CD38 until a specified time in 2031, followed by 13-20% tiered royalties on sales thereafter. Should Janssen not exercise its option, the terms of the agreement allow Genmab to continue to develop and commercialize Hexa-Body-CD38 for DARZALEX-resistant patients, and in all other indications except those multiple myeloma or amyloidosis indications where DARZALEX is either approved or is being actively developed. The agreement is the outcome of pre-clinical research on novel CD38 targeting concepts conducted by Genmab. HexaBody-CD38 showed encouraging in vitro complement-dependent cytotoxicity (CDC) activity in B-cell lymphoma and leukemia, including for cells with low CD38 expression levels. HexaBody-CD38 also showed similar antibody-dependent cellular cytotoxicity (ADCC) in vitro compared to daratumumab. Updates from First Quarter to Third Quarter September: Entered into a strategic collaboration agreement with Tempus, building upon existing service agreements between the companies. Under the terms of the agreement, the companies will also jointly work on research projects that are identified by Genmab to explore novel product concepts and biomarkers. For any resulting products, Genmab will lead all development and commercial activities. Tempus will be eligible for undisclosed milestones and royalties from Genmab and will also have the option to fund part of product development programs in exchange for increased royalty payments due to Tempus under the agreement. Q3: Two antibody research programs at Gilead Sciences, Inc., which incorporated Genmab’s DuoBody technology, were concluded and the underlying Research Evaluation Agree-ments, signed in 2014 and 2016, were terminated. July: Entered into an agreement with BliNK Biomedical for an exclusive commercial license to certain antibodies targeting CD47, for potential development and commercialization into novel bispecific therapeutics created via Genmab’s propri-etary DuoBody Platform technology. Under the terms of the agreement, Genmab paid BliNK Biomedical an upfront fee of USD 2.25 million. BliNK Biomedical is also eligible to receive up to approximately USD 200 million in development, regulatory and commercial milestone payments for each product, as well as tiered royalties on net sales. The first presentation of pre-clinical data for HexaBody-CD38 occurred at the 61st ASH Annual Meeting. November: IND was filed for DuoHexaBody-CD37. The first presentation of pre-clinical data for Duobody-CD3x5T4 occurred at the 34th Society for Immunotherapy of Cancer Annual Meeting. June: Entered into exclusive worldwide license and option agreement with Janssen to develop and commercialize HexaBody-CD38, a next-generation human CD38 monoclonal Management’s Review / Pre-clinical Programs 44

Antibody Technologies Antibodies are Y-shaped proteins that play a central role in immunity against bacteria and viruses (also known as pathogens). As we develop immunity, our bodies generate antibodies that bind to pathogen structures (known as anti-gens), which are specific to the pathogen. Once bound, the antibodies attract other parts of the immune system to elim-inate the pathogen. In modern medicine, we have learned how to create and develop specific antibodies against antigens associated with diseased human cells for use in the treatment of diseases such as cancer and autoimmune disease. Genmab uses several types of technologies to create antibodies to treat disease and has developed proprietary antibody technologies including the DuoBody, HexaBody, DuoHexaBody and HexElect platforms. Information about these technologies can be found in the following sections and at http://www.genmab.com/research-and-technology/ genmab-technology. Platform Principle Applications DuoBody Bispecific antibodies Dual-targeting: • Recruitment (e.g., T cells) • Tumor heterogeneity HexaBody Target-mediated enhanced hexamerization Enhanced potency: • Complement-dependent cytotoxicity (CDC) • Target clustering, outside-in signaling, apoptosis DuoHexaBody Bispecific antibodies with target-mediated enhanced hexamerization Dual-targeting + enhanced potency: • CDC • Target clustering, outside-in signaling, apoptosis We also use or license several other technologies to gener-ate diverse libraries of high quality, functional antibodies such as the OmniAb® transgenic mouse and rat platforms from Ligand Pharmaceuticals, Inc. We also use or license technologies to increase the potency of some of our antibody therapeutics on a product-by-product basis such as the ADC technology from Seattle Genetics. ADCs are antibodies with potent cytotoxic agents coupled to them. By using antibodies that recognize specific targets on tumor cells, these cytotoxic agents are preferentially delivered to the tumor cells. HexElect Two co-dependent antibod-ies with target-mediated enhanced hexamerization Dual-targeting + enhanced potency and selectivity: • Co-dependent unlocking of potency • New target space, previously inaccessible Management’s Review / Antibody Technologies 45

DuoBody Platform The innovative DuoBody technology platform generates bispecific antibodies via a fast, versatile, and broadly applicable process, called controlled Fab-arm exchange. With only minimal protein engineering the technology allows the binding arms of two distinct monoclonal antibodies to exchange, combining into one stable bispecific antibody, thereby retaining regular immunoglobulin structure and function. The DuoBody platform is also highly suitable for high throughput generation, screening, and discovery of bispecific antibodies in the final format. IDnunooBvoatdivyePTleactfhonromlogy for Bispecific Antibody Therapeutics The DuoBody platform is Genmab’s innova-tive platform for the discovery and develop-ment of bispecific antibodies. Bispecific antibodies bind to two different epitopes (or “docking” sites) either on the same, or on different targets (also known as dual-target-ing). Dual-targeting may improve binding specificity and enhance therapeutic efficacy or bring two different cells together (for example, engaging a T cell to kill a tumor cell). Bispecific antibodies generated with the DuoBody platform can be used for the development of therapeutics for diseases such as cancer, autoimmune, infectious, cardiovascular, and central nervous system diseases, and hemophilia. DuoBody molecules combine the benefits of bispeci-ficity with the strengths of conventional antibodies, which allows DuoBody mole-cules to be administered and dosed the same way as other antibody therapeutics. Genmab’s DuoBody platform generates bispecific antibodies via a versatile and broadly applicable process which is easily performed at high throughput, standard bench, as well as commercial manufacturing scale. Genmab uses the DuoBody platform to create its own bispecific antibody programs and the technology is also available for licensing. Genmab has numerous alliances for the DuoBody platform including commer-cial collaborations with Janssen, Novo Nordisk, BioNTech and BliNK Biomedical. In short • Bispecific antibody technology platform + • Potential in cancer, autoimmune, infectious, cardiovascular, central nervous system diseases and hemophilia • Commercial collabo-rations with Janssen, BioNTech, Novo Nordisk and BliNK Biomedical plus multiple research collab-orations Management’s Review / DuoBody Platform 46

Commercial DuoBody Janssen Biotech, Inc. BioNTech In July 2012, Genmab entered into a collaboration with Jans-sen Biotech, Inc. to create and develop bispecific antibodies using our DuoBody platform. Under this original agreement, Janssen had the right to use the DuoBody technology to create panels of bispecific antibodies (up to 10 DuoBody programs) to multiple disease target combinations. Genmab received an upfront payment of USD 3.5 million from Jans-sen and will potentially be entitled to milestone and license payments of up to approximately USD 175 million, as well as royalties for each commercialized DuoBody product. In May 2015, Genmab entered an agreement with BioNTech AG to jointly research, develop and commercialize bispecific antibody products using Genmab’s DuoBody technology platform. Under the terms of the agreement, BioNTech will provide proprietary antibodies against key immunomod-ulatory targets, while Genmab provides antibodies and access to its DuoBody technology platform. Genmab paid an upfront fee of USD 10 million to BioNTech and an additional USD 2 million (out of a potential of USD 5 million) as certain BioNTech assets were selected for further development. If the companies jointly select any product candidates for clinical development, development costs and product ownership will be shared equally going forward. If one of the companies does not wish to move a product candidate for-ward, the other company is entitled to continue developing the product on predetermined licensing terms. The agree-ment also includes provisions which will allow the parties to opt out of joint development at key points. Genmab and BioNTech have selected two product candidates for clinical development, DuoBody-CD40x4-1BB (GEN1042) and DuoBody-PD-L1x4-1BB (GEN1046), both of which are now in Phase I clinical trials. Product Collaborations Under the terms of a December 2013 amendment, Jans-sen was entitled to work on up to 10 additional programs. Genmab received an initial payment of USD 2 million from Janssen. Under the terms of the original agreement, for each of the additional programs that Janssen successfully initiates, develops and commercializes, Genmab will poten-tially be entitled to receive average milestone and license payments of approximately USD 191 million. In addition, Genmab will be entitled to royalties on sales of any commer-cialized products. All research work is funded by Janssen. As of December 31, 2018, Janssen had exercised 14 licenses under this collaboration. No further options remain for use by Janssen. As of December 31, 2019, six DuoBody product candidates created under this collaboration were in the clinic. Management’s Review / DuoBody Platform 47

Novo Nordisk BliNK Biomedical In August 2015, Genmab entered an agreement to grant Novo Nordisk commercial licenses to use the DuoBody technology platform to create and develop bispecific antibody candidates for two therapeutic programs. The bispecific antibodies will target a disease area outside of cancer therapeutics. Under the terms of the agreement, Genmab received an upfront payment of USD 2 million from Novo Nordisk. After an initial period of exclusivity for both target combinations, Novo Nordisk has extended exclusivity of the commercial license for one target combination in 2018. Under the exclusive license agreement, Genmab is entitled to potential development, regulatory and sales milestones of up to approximately USD 250 million. In addition, Genmab will be entitled to single-digit royalties on sales of any commercialized products. In December 2017, the collaboration was expanded to include an additional five po-tential target pair combinations and three commercial license options. Genmab received an upfront payment of USD 2 million from Novo Nordisk and will be entitled to milestones and single digit royalties on eventual product sales. The first clinical trial for Mim8, a DuoBody product candidate for hemophilia being developed by Novo Nordisk under this collaboration, was pub-lished on www.clinicaltrials.gov in December. In July 2019, Genmab entered into an agreement with BliNK Biomedical for an exclusive commercial license to certain antibodies targeting CD47, for potential development and commercialization into novel bispecific therapeutics created via Genmab’s proprietary DuoBody Platform tech-nology. Under the terms of the agreement, Genmab paid BliNK Biomedical an upfront fee of USD 2.25 million. BliNK Biomedical is also eligible to receive up to approximately USD 200 million in development, regulatory and commer-cial milestone payments for each product, as well as tiered royalties on net sales. Management’s Review / DuoBody Platform 48

HCreexaatBinogdDyifPfelaretfnotrimated Therapeutics The HexaBody technology platform is a pro-prietary Genmab technology that is designed to increase the potency of antibodies. The HexaBody platform builds on natural biology and strengthens the natural killing ability of antibodies while retaining regular structure and specificity. The technology allows for the creation of potent therapeutics by inducing antibody hexamer formation (clusters of six antibodies) after binding to their target antigen on the cell surface. We have used the HexaBody platform to generate antibod-ies with enhanced complement-mediated killing, allowing antibodies with limited or absent killing capacity to be transformed into potent, cytotoxic antibodies. In addi-tion to complement-mediated killing, the clustering of membrane receptors by the HexaBody platform can lead to subsequent outside-in signaling (e.g. in the case of our HexaBody-DR5/DR5 product) leading to cell death. The HexaBody technology creates opportunities to explore new product candidates, to repurpose drug candidates unsuccessful in previous clinical trials due to insufficient potency, and may provide a useful strategy in product life cycle manage-ment. The HexaBody technology is broadly applicable and can be combined with Genmab’s DuoBody platform (DuoHexaBody platform) as well as other antibody technol-ogies. The technology has the potential to enhance antibody therapeutics for a broad range of applications in diseases such as cancer and infectious diseases. Genmab in-tends to use the HexaBody technology for its own antibody programs and the technology is also available for licensing. In addition to multiple HexaBody research collaborations with other companies, Genmab has entered into an exclusive worldwide license and op-tion agreement with Janssen to develop and commercialize HexaBody-CD38, a next-generation CD38 monoclonal antibody prod-uct incorporating the HexaBody technology. In Short • Enhanced potency anti-body technology platform • Broadly applicable technology that builds on natural antibody biology • First HexaBody product in clinical development – HexaBody-DR5/DR5 Management’s Review / HexaBody Platform 49

The HexaBody platform is an innovative approach for the creation of potent therapeutics. It builds on recent insights in the natural biology of antibodies. The technology enhances the ordered clustering of antibodies into hexamers after they bind to their target cells. This biological mechanism can be exploited to robustly enhance cell killing via complement-dependent cytotoxicity (CDC) or agonist outside-in signaling induced by clustering. The HexaBody platform can be combined with Genmab’s DuoBody platform as well as with other antibody technologies. target cell antigen binding hexamerization CDC induction outside-in signaling cascade Management’s Review / HexaBody Platform 50 Clustering: complement MAC

DCoumoHbeinxianBgoDduyaPl-lTaatrfgoertming and Enhanced Potency The DuoHexaBody platform is a proprietary technology that combines the dual-targeting of our DuoBody technology with the enhanced potency of our HexaBody technology, creating bispecific antibodies with target-mediated enhanced hexamerization. We currently have one proprietary bispecific antibody product created with DuoHexaBody technology, DuoHexaBody-CD37 with potential in hematological malignancies. Following an IND filing in November, DuoHexaBody-CD37 is anticipated to be in the clinic in 2020. In Short • Antibody technology that combines DuoBody and HexaBody platforms • Creates bispecific antibodies with target-mediated enhanced potency • First IND for a DuoHexa-Body product candidate, DuoHexaBody-CD37, submitted in 2019 Management’s Review / DuoHexaBody Platform 51

HEnehxaEnleccint gPlSaetlfeocrmtivity and Potency The HexElect antibody platform is Genmab’s newest proprietary technology. This tech-nology combines two HexaBody molecules designed to effectively and selectively hit only those cells that express both targets by making the activity of complexes of HexaBody molecules dependent on their binding to two different targets on the same cell. The HexElect platform maximizes efficacy while minimizing possible toxicity, potentially lead-ing to more potent and safer products. In Short • Antibody technology platform inspired by the HexaBody platform • Combines dual-targeting with enhanced selectivity and potency Management’s Review / HexElect Platform 52

Commitment to Building a Sustainable and Socially Responsible Biotech The Board of Directors and Senior Leadership at Genmab are committed to Genmab’s business-driven CSR strategy as well as its efforts to build a sustainable organization that meets environmental, social and governance (ESG) criteria of relevance to its business operations. Below are some examples of Genmab's CSR & ESG initiatives: Commitment to Business Ethics Commitment to the Environment Commitment to Transparency Genmab adheres to its Code of Business Conduct and Ethics which sets high ethical standards of all Genmab employees and the Board of Directors, and promotes and enforces the principles around anti-bribery and anti-corruption: https://ir.genmab.com/ code-business-conduct-ethics Genmab facilities are equipped with BREEAM (Building Research Establishment Environ-mental Assessment Method) certifications of various grades: https://ir.genmab.com/ corporate-social-responsibility The products and conduct of non-clinical and clinical trials met Danish, European, US and Japanese regulations including International requirements (OECD/ICH). Genmab’s activities are anchored in the company’s core purpose “to improve the lives of patients by creating and developing innovative antibody products,” thus creating value over the long term not only for its employees and shareholders, but also for patients who may benefit from Genmab’s innovation. Through our reports on Governance, CSR, and Compensation, Genmab has established a framework to set goals and track our performance against these goals. As the reporting of sustainability metrics continues to evolve over the years, Genmab has and will continue to adapt and improve its metrics and disclosures. As a leading international biotechnology company, Genmab has high standards for reporting requirements. Genmab’s core values and vision are the foundation for its commitment to building a sustainable and socially responsible biotech company. The Board of Directors has established and appointed a Compensation Committee, an Audit and Finance Committee, a Nominating and Corporate Governance Committee and a Scientific Committee. First laboratories in the Netherlands to obtain a BREEAM Excellent certification. Genmab is committed to diversity at all levels of the company and strives to recruit and retain employees with the right skills and competences, regardless of gender, natio-nality and other differences. Committed to developing a remuneration policy that incorporates enduring remu-neration principles and is responsive to shareholder concerns. View the Genmab Compensation Report: https://ir.genmab. com/corporate-governance Facilities in Denmark have a BREEAM Very Good certification and the future U.S. site will have a Leadership in Energy and Environ-mental Design (LEED) Silver certification. 59/41% of women and men in the workplace 52% of women employees director level and above 37.5% of women in senior leadership roles 1/3 Women Board of Directors 42 Nationalities Management’s Review / Commitment to Building a Sustainable and Socially Responsible Biotech 53

Manliement's Rt M

Corporate Governance Genmab works diligently to improve its guidelines and policies for corporate governance taking into account the recent trends in international and domestic requirements and recommendations. Genmab’s commitment to corporate governance is based on ethics and integrity and forms the basis of its effort to strengthen the confidence that existing and future shareholders, partners, employees and other stakeholders have in Genmab. The role of shareholders and their interaction with Genmab is important. Genmab acknowledges that open and transparent communication is necessary to maintain the confidence of Genmab’s share-holders and achieves this through company announcements, investor meetings and company presentations. Genmab is committed to providing reliable and transparent information about its business, financial results, development programs and scientific results in a clear and timely manner. without the acceptance of the general meeting. Genmab does not have such a restriction in its takeover contingency procedures and retains the right in certain circumstances to reject takeover bids without consulting the shareholders. Genmab believes this provides the Board of Directors with the needed flexibility to best respond to takeover bids and to negotiate with bidders. Actions will be determined on a case-by-case basis with due consideration to the interests of the shareholders and other stakeholders. express dissenting views and to ensure that the indepen-dence of the members of our Board of Directors cannot be questioned, the Board of Directors is considering to amend the RSU program. • The Recommendations provide that the total value of the remuneration relating to the notice period, including severance pay, does not exceed two years of remunera-tion, including all components of the remuneration. In the event Genmab terminates the service agreements with each member of the Executive Management team without cause, Genmab is obliged to pay the Executive Manage-ment member his/her existing salary (including benefits) for one or two years after the end of the one year notice period. Also, in the event of termination by Genmab (unless for cause) or by a member of the Executive Management as a result of a change of control of Genmab, Genmab is obliged to pay a member of the Executive Management compensation equal to his/her existing total salary (including benefits and a bonus) for up to two years in addition to the notice period. It furthermore follows from Genmab’s warrant and RSU programs that, in certain “good leaver” situations, outstanding warrants and RSUs awarded under these programs will continue to vest. Depending on the circumstances, one of the aforemen-tioned events, or a combination thereof, could potentially make the termination payments exceed two years of remuneration. • The Recommendations provide that remuneration of the board members shall not include share options. However, Genmab’s compensation of the board members includes restricted stock units (RSUs), which, like share options, are considered a form of equity compensation. Equity compen-sation constitutes a common part of the compensation paid to members of the board of directors in competing interna-tional biotech companies. This is supported by a bench-mark analysis conducted in 2019 by an independent compensation consultant. To remain competitive in the international market and to be able to attract and retain qualified members of the Board of Directors, it is consid-ered in the best interest of Genmab to follow this practice, which we believe is aligned to serve the shareholders’ long-term interests. Furthermore, to ensure the Board of Directors’ independence and supervisory function, vesting of RSUs granted to members of the Board of Directors shall not be subject to fulfilment of forward-looking performance criteria. To address concerns raised by shareholders and their representatives that continued service as a vesting condition for RSU awards to members of the Board of Directors could be a disincentive for such members to All Danish companies listed on the Nasdaq Copenhagen are required to disclose in their annual reports how they address the Recommendations for Corporate Governance issued by the Committee on Corporate Governance in November 2017, (the “Recommendations”) applying the “comply-or-explain” principle. Genmab follows the vast majority of the Recommendations, although specific sub-areas have been identified where Genmab’s corporate governance principles differ from the Recommendations as follows: • The Recommendations provide that according to a compa-ny’s takeover contingency procedures, the board of directors shall not attempt to counter a takeover bid Genmab publishes its statutory report on Corporate Gover-nance for the financial year 2019 cf. Section 107 b of the Danish Financial Statements Act (“Lovpligtig redegørelse Management’s Review / Corporate Governance 55

for virksomhedsledelse jf. årsregnskabslovens § 107 b”) on the company’s website, including a detailed description of the Board of Directors’ consideration in respect of all the Recommendations. The statutory report on Corporate Governance can be found on Genmab’s website https:// ir.genmab.com/corporate-governance. by each member of the Board of Directors and the Executive Management from Genmab A/S and other group companies for the last three years, including information on the most important content of retention and resignation arrangements and the correlation between the remuneration and company strategy and relevant related goals (the “Compensation Report”). The Compensation Report can be found on Genmab’s website https://ir.genmab.com/corporate-governance. GUIDELINES FOR INCENTIVE REMUNERATION Pursuant to the previous section 139 of the Danish Compa-nies Act (in Danish “Selskabsloven”), the board of directors was required, before the company entered into a specific incentive payment agreement with a member of the board of directors or executive management, to lay down general guidelines governing the company’s incentive remuneration of such member. The general guidelines are included in the Remuneration Principles for the Board of Directors and the Executive Management which have been considered and adopted at Genmab’s annual general meeting. The Remuner-ation Principles can be found in their full length on our website www.genmab.com. The guidelines were adopted at the 2008 annual general meeting and most recently amend-ed by the annual general meeting of the company in 2019. All incentive payments are carried out in accordance with Genmab’s Remuneration Principles. THE BOARD OF DIRECTORS The Board of Directors plays an active role within Genmab in setting the strategies and goals for Genmab and monitoring the operations and results of the company. Board duties include establishing policies for strategy, accounting, organization and finance, and the appointment of Executive Management members. The Board of Directors also assesses Genmab’s capital and share structure and is responsible for approving share issues and the grant of warrants and RSUs. DISCLOSURE REGARDING CHANGE OF CONTROL The Danish Financial Statements Act (Section 107 a) contains rules relating to listed companies with respect to certain disclosures that may be of interest to the stock market and potential takeover bidders, in particular in relation to disclosure of change of control provisions. For information on change of control clauses in our collaboration, development and license agreements as well as certain service agreements with the Executive Management and employees, please refer to note 5.5. Change of control clauses related to our warrant and RSU programs are outlined in note 4.6. BOARD COMMITTEES To support the Board of Directors in its duties, the Board of Directors has established and appointed a Compensation Committee, an Audit and Finance Committee, a Nominating and Corporate Governance Committee and a Scientific Committee. These committees are charged with reviewing issues pertaining to their respective fields that are due to be considered at board meetings. Written charters specifying the tasks and responsibilities for each of the committees are available on Genmab’s website www.genmab.com. In accordance with the newly implemented sections 139 and 139a of the Danish Companies Act, Genmab has prepared a Remuneration Policy regarding the remuneration of Genmab’s Board of Directors and Executive Management. The Remuner-ation Policy will be presented to the shareholders and proposed to be adopted at the Annual General Meeting in 2020. Upon adoption the Remuneration Policy will supersede the Remuneration Principles. More information on share capital is included in note 4.7. Unless otherwise provided in the Danish Companies Act, the adoption of any resolution to amend Genmab A/S’ articles of association shall be subject to the affirmative vote of not less than two thirds of the votes cast as well as of the voting share capital represented at the general meeting. Genmab A/S’ entire articles of association can be found on our website (www.genmab.com). Compensation Report In accordance with the Recommendations, Genmab has prepared a compensation report for the financial year 2019 that includes information on the total remuneration received For more details on the work and composition of the Board of Directors and its committees, reference is made to the statutory report on Corporate Governance. Management’s Review / Corporate Governance 56

• Management's Review

Corporate Social Responsibility (CSR) and Sustainability Commitments The Board of Directors and Senior Leadership at Genmab are committed to Genmab’s business-driven CSR strategy, which focuses on four main areas: ways to improve healthcare and quality of life for patients and their families. We are committed to creating differentiat-ed antibody products that have the potential to provide new treatment options to patients with life threatening and debilitating diseases. Our CSR Committee is chaired by a member of our Executive Management Team and is comprised of representatives from our human resources, investor relations and communica-tions, legal, finance and research and development func-tions. Genmab is equally committed to building a sustainable organization that meets environment, social and governance (ESG) criteria of relevance to our business operations. In 2020, our goal is to further review ESG considerations in closer detail and integrate these into our strategic planning and risk management process. The committee ensures that Genmab carries out its CSR activities effectively and commu-nicates clearly and openly about them. We believe we have a responsibility to ensure our actions not only benefit our main stakeholders (patients, sharehold-ers and employees), but also society as a whole. With our core values and vision in mind, being socially responsible is fundamental to the way we do business at Genmab. Employee Environment including waste manage-ment and recycling Well-being including health, safety and development In carrying out our business we strive to comply with all relevant laws, standards and guidelines. We also consider the well-being of our employees a top priority, and we minimize our impact on the environment to the extent possible. We have high ethical standards and aim to conduct business with companies and within countries that share our ethics and respect the protection of internationally pro-claimed human rights. As we conduct business in a highly regulated industry, we have chosen not to implement a specific human rights policy. It is important to us, however, to support and respect the protection of internationally proclaimed human rights through other policies that address responsible supply chain management, ethical procedures, health and safety procedures, and issues regarding access to medicine. Genmab strives to only conduct clinical trials in markets where a drug is planned to become available. Furthermore, Genmab does not employ child labor. Genmab publishes its statutory report on CSR for the financial year 2019 cf. Section 99 a of the Danish Financial Statements Act on the company’s website, including additional information about policies, progress made during 2019 and expected activities for 2020. Genmab has adopted a target figure for women in the Board of Directors and a policy regarding the proportion of gender in other manage-ment levels of the Genmab group. Both of these goals have been met with equitable gender representation in the Board of Directors and with women holding 52% of all director level and above positions. In accordance with section 99 b of the Danish Financial Statements Act, Genmab discloses the target figure, the policy and current performance in its statutory report on CSR for the financial year 2019. The statutory report on CSR can be found at https://ir.genmab.com/corporate-social-responsibility. Business Ethics Ethics and transparency in relation to pre-clinical and clinical studies Our vision – “By 2025 our own product has transformed cancer treatment and we have a pipeline of knock-your-socks-off antibodies” – inspires and motivates us to find new Management’s Review / Corporate Social Responsibility (CSR) and Sustainability Commitments 58

Human Capital Management Genmab group 41% 59% Male Female Employees are Genmab’s most important resource and we strive to attract and retain the most qualified people to fulfil our core purpose. Genmab’s goal is to develop and retain value in our own products which could one day transform cancer treatment. At Genmab, our core purpose, together with our core values, guides and inspires employees in their everyday work. Skill, knowledge, experience and employee motivation are essential to Genmab as a biotech company. The ability to organize our highly skilled and very experienced em-ployees at all levels of the organization into interactive teams is a key factor in achieving our goals and ensuring Genmab’s success. Genmab’s team is very experienced in the pharmaceutical and biotechnology industry. Male/Female Ratios 2019 2018 Male Female Male Female Genmab group 41% 59% 41% 59% Director level and above 48% 52% 45% 55% Below director level 37% 63% 39% 61% Annual promotions 44% 56% 44% 56% Other Employee Information 2019 2018 FTE at the end of the year 548 377 Teamwork and respect are central pillars of Genmab’s culture, and we therefore ensure an inclusive, open and supportive profes-sional work environment across our interna-tional locations. We believe that fostering workplace diversity across social, education-al, cultural, national, age and gender lines is a prerequisite for the continued success of the company. We are committed to diversity at all levels of the company and strive to recruit employees with the right skills and competences, regardless of gender, age, ethnicity and other differences. Research and development FTE 468 323 Administrative FTE 80 54 FTE in Denmark at the end of the year FTE in Netherlands at the end of the year 154 268 113 197 FTE in US at the end of the year 125 67 FTE in Japan at the end of the year 1 – Employee turnover1 8% 6% Employee absence2 3% 3% 1 Employee turnover percentage is calculated by the FTE voluntarily leaving since the beginning of the year divided by the average FTE. 2 The rate of absence is measured as absence due to the employee’s own illness, pregnancy-related sick leave, and occupational injuries and illnesses compared with a regional standard average of working days in the year, adjusted for holidays. Management’s Review / Human Capital Management 59

Our Core Values Passion for innovation Work as one team and respect each other Our Core Purpose To improve the lives of patients by creating and developing innovative Determined – being the best at what we do antibody products 60 Integrity – we do the right thing

Risk Management Management’s Review / Risk Management 61

Genmab has core facilities in four countries and performs re-search and development activities with clinical trials conduct-ed around the globe. Through our activities, we are exposed to a variety of risks, some of which are beyond our control. These risks may have a significant impact on our business if not properly assessed and controlled. Maintaining a strong control environment, with adequate procedures for identifi-cation and assessment of risks and adhering to operational policies designed to reduce such risks to an acceptable level, is essential for the continued development of Genmab. It is our policy to identify and reduce the risks derived from our operations and to establish insurance coverage to mitigate any residual risk, wherever considered practicable. The Board of Directors performs a yearly review of Genmab’s insurance coverage to ensure that it is adequate. The following is a summary of some of Genmab’s key risk ar-eas and how we attempt to address and mitigate such risks. Environmental and ethical risks are covered in Genmab’s statutory report on Corporate Social Responsibility. Management’s Review / Risk Management 62

Risk Related to Risk Areas Mitigation Risk Trend Identification and development of successful products, expen-sive, time-consuming clinical trials with uncertain outcome and risk of failure to obtain regulatory approval in one or more jurisdictions Genmab has established various committees to ensure optimal selection of disease targets and formats of our antibody candidates and to monitor progress of preclinical and clinical development. We strive to have a well-balanced product pipeline and continue to identify and search for new product candidates and closely follow the market. Business Dependent on identification and development of new propri-etary technologies and access to new third party technologies, such as ADC technology, including exposure to safety issues, as well as other failures and setbacks related to use of such new or existing technologies Genmab strives to continue its identification and development of new technologies, such as the DuoBody, HexaBody, DuoHexaBody and HexElect platforms and gain access to competitive new third party technologies such as ADC technology and mRNA technology. We closely monitor our preclinical programs and clinical trials to mitigate any unforeseen safety issues or other failures or setbacks associated with the use of our proprietary platform technologies or ADC technology. Genmab faces uncertainty about the successful commercializa-tion of product candidates. This is a result of factors including immense competition on the basis of cost and efficacy as well as rapid technological change, which may result in others discover-ing, developing or commercializing competing products before or more successfully than us From early in the research phase and throughout development, commercial potential and risks are assessed to ensure that final products have the potential to be commercially viable. Genmab attempts to control commercial risks by monitoring and evaluating current market conditions, competing products and new technologies and to potentially gain access to new technologies and products that may supplement our pipeline. Genmab strives to ensure market exclusivity for its own technologies and products by seeking patent protection. Near-and mid-term prospects are substantially dependent on continued clinical and commercial success of DARZALEX DARZALEX is subject to intense competition in the multiple myeloma therapy market Genmab focuses on its three-pronged strategy to develop a broad pipeline of unique best-in-class or first-in-class antibodies with significant commercial potential. In addition, Genmab maintains a strong cash position, disciplined financial management, and a flexible and capital efficient business model to mitigate potential setbacks for DARZALEX. In 2019 Genmab entered into an exclusive license agreement with Janssen regarding next-generation CD38 antibody product, HexaBody®-CD38. Exposure to product liability claims related to the use or misuse of our products and technologies A product liability claim could materially affect our business and financial position and Genmab therefore maintains product liability insurance for our clinical trials and other coverage required under applicable laws. If we are unable to manage Genmab’s fast-paced growth or build our commercialization capabilities, our business, finan-cial condition, and net results may be adversely affected Genmab continues to experience significant growth in the number of our employees and in the scope of our operations, including the continued expansion of our product pipeline and development of our commercialization capabilities. Genmab must continue to improve existing operational and financial systems, procedures and controls. Genmab must expand, train and manage our growing employee base, and we expect that we may need to increase our manage-ment personnel to oversee our expanding operations. Government restrictions on pricing/public reimbursement, as well as other healthcare payor cost-containment initiatives Increased pressures by governmental and third party payors to reduce health care costs Genmab strives to develop differentiated, cost-effective products that may obtain price reimbursement by government health care programs and private health insurers. Risk level in relation to last year: New Unchanged Increased Decreased Management’s Review / Risk Management 63

Risk Related to Risk Areas Mitigation Risk Trend Dependent on existing and new partnerships with major phar-maceutical or biotech companies to support our business and develop and commercialize our products Our business may suffer if our collaboration partners do not devote sufficient resources to our programs and products, do not successfully maintain, defend and enforce their intellectual property rights or do not otherwise have the ability to successfully develop or commercialize our products, independently or in collaboration with us. Our business may also suffer if we are not able to continue our current partnerships or establish new partnerships. Genmab strives to be an attractive and respected collaboration partner and to pursue a close and open dialogue with our partners to share ideas and best practices within clinical development to increase the likelihood that we reach our goals. Strategic collaborations Primarily dependent on one contract manufacturing organi-zation to produce our product candidates and dependent on clinical research organizations to conduct our clinical trials Genmab oversees outsourcing relationships to ensure consistency with strategic objectives and service provider compliance with regulatory requirements, resources and performance. This includes assessment of contingency plans, availability of alternative service providers, and costs and resources required to switch service providers. Subject to extensive regulatory and other legal requirements both during clinical development and post-marketing approval, including healthcare laws and regulations, as well as data protection regulations To ensure compliance with regulatory and other legal requirements including current Good Laboratory Practices (cGLP), current Good Clinical Practices (cGCP) and current Good Manufacturing Practices (cGMP), Genmab has established a quality assurance department and makes every effort to stay abreast of regulatory changes to legislation to ensure compliance. To ensure compliance with applicable healthcare laws and regulations, Genmab has established relevant policies and guidelines, including pharma compliance guidelines and guidelines for the processing and protection of personal data. The data protection area is overseen by the Company’s DPO (Data Protection Officer). Regulation and legislation Subject to strict disclosure obligations under applicable laws and regulations, including the EU Market Abuse Regulation. As a consequence of the listing on the Nasdaq Global Select market, we are subject to additional U.S. regulatory require-ments, including U.S. securities laws and the U.S. Foreign Corrupt Practices Act, and may become more exposed to U.S. class actions Genmab has established relevant procedures and guidelines to ensure timely, adequate and correct information to the market and otherwise comply with U.S. securities laws and regulatory requirements. Legislation, regulations and practices may change from time to time To prevent unwarranted consequences of new and amended legislation, regulations etc., Genmab strives to be up to date with all relevant new legislation, regulations and practices by means of internal, as well as external, legal counsel. Also, internal procedures for review of contracts have been implemented to ensure contractual consistency and compliance with legislation and regulation. Risk level in relation to last year: New Unchanged Increased Decreased Management’s Review / Risk Management 64

Risk Related to Risk Areas Mitigation Risk Trend Dependent on protecting own intellectual property rights to regain our investments and protect our competitive position We may become involved in lawsuits to protect or enforce our patents or other intellectual property which could result in costly litigation and unfavorable outcomes Claims may be asserted against us that we infringe the intellec-tual property of third parties could result in costly litigation and unfavorable outcomes Genmab files and prosecutes patent applications to optimally protect its products and tech-nologies. To protect trade secrets and technologies, Genmab maintains strict confidentiality standards and agreements for employees and collaborating parties. Intellectual property Genmab actively monitors third party patent positions within our relevant fields to avoid vio-lating any third party patent rights. Genmab was involved, as a defendant, in a patent litigation case in the U.S. relating to the manufacture, use and sale of DARZALEX. The plaintiff’s patents were held invalid in a summary judgment decision in January 2019. Thereafter, the parties agreed to dismiss their respective claims. As a result, there will be no further proceedings and the case has come to a final reso-lution. Please refer to note 5.5 of the financial statements for additional information regarding the legal matter. Genmab may need additional funding Because Genmab’s future commercial potential and operating results are hard to predict, Genmab’s policy is to maintain a strong capital base so as to maintain investor, creditor and market confidence, and a continuous advancement of Genmab’s product pipeline and business in general. Finances Genmab is exposed to different kinds of financial risks, including currency exposure and changes in interest rates as well as changes in Danish, U.S. or foreign tax laws or compli-ance requirements The financial risks of the Genmab group are managed centrally. Group financial risk management guidelines have been established to identify and analyze the risks faced by the Genmab group, to set the appropriate risk limits and controls and to monitor the risks and adherence to limits. Please refer to note 4.2 of the financial statements for additional information regarding financial risks. Inability to attract and retain suitably qualified personnel To attract and retain our highly skilled workforce, including the members of Genmab’s Senior Lead-ership, Genmab offers competitive remuneration packages, including share-based remuneration. Genmab strives to create a good and sound working environment with development opportunities for its employees. Genmab has strong core values that nourish high integrity and ethical behavior, respectful and candid tone, as well as trust and teamwork. Please refer to note 4.6 of the financial statements for additional information regarding share-based remuneration. Management and workforce Theft of intellectual property rights, sensitive business data, personal employee data, or private patient data, which may re-sult in monetary losses or fines and penalties from authorities, could stem from the result of malicious hacking activities Genmab educates its organization in methods to address exposure to cyber security threats and is actively working to improve the technical ability to protect against, detect and respond to attempts to enter its IT infrastructure. Cyber security Risk level in relation to last year: New Unchanged Increased Decreased Management’s Review / Risk Management 65

Financial Review The financial statements are prepared on a consolidated basis for the Genmab group and are published in Danish Kroner (DKK). Management’s Review / Financial Review 66

Of the revenue for 2019, DKK 3,155 million, or 59%, was attributable to royalties, DKK 1,869 million, or 35% to milestone payments and DKK 342 million, or 6%, to reim-bursement income. This is compared to DKK 1,741 million, or 58%, attributable to royalties, DKK 687 million, or 23%, to milestone payments, DKK 348 million, or 11%, to license fees and DKK 249 million, or 8%, to reimbursement income in 2018. payments achieved in 2019, as compared to 2018. In 2019, we recorded DKK 1,778 million (USD 264 million) in DARZ-ALEX milestone payments from Janssen, including (i) a USD 150 million milestone payment related to the achievement of USD 3.0 billion in net sales (as calculated on the basis of the license agreement terms) of DARZALEX in calendar year 2019, (ii) a USD 100 million milestone payment related to the achievement of USD 2.5 billion in net sales of DARZALEX in calendar year 2019, and (iii) USD 14 million milestone pay-ments related to the first commercial sales of DARZALEX in Japan in the third and fourth indications under the expanded labels. The remaining DKK 91 million included milestone payments related to pre-clinical and clinical progress under our DuoBody collaboration with Janssen and other collabora-tions. By comparison, in 2018, we recorded DKK 586 million (USD 90 million) in DARZELEX milestone payments from Janssen, including (i) a USD 75 million payment related to achievement of USD 2.0 billion in net sales of DARZALEX in the fourth quarter of 2018 and (ii) a USD 13 million milestone payment related to the first sale of DARZALEX in combination with VMP in patients with newly diagnosed multiple my-eloma. The remaining DKK 101 million included milestone payments related to pre-clinical and clinical progress under our DuoBody collaboration with Janssen and other collabo-rations. Milestone income may fluctuate significantly from period to period due to both the timing of achievements and the varying amount of each individual milestone under our license and collaboration agreements. Result for the Year Result and Guidance Latest Guidance for 2019 (DKK million) Actual Revenue 5,100 5,366 Operating expenses (2,750) (2,728) Operating income 2,350 2,638 Revenue was above guidance primarily due to a combination of an additional DARZALEX milestone and USD/DKK foreign exchange rate movements which positively impacted rev-enue. Operating expenses were in line with guidance. Operat-ing income was above guidance due to higher revenue. The latest guidance was published on November 6, 2019. Royalties Royalty income amounted to DKK 3,155 million in 2019 compared to DKK 1,741 million in 2018. The increase of DKK 1,414 million, or 81%, was driven by higher DARZALEX royalties, which were partly offset by lower Arzerra royalties. Net sales of DARZALEX by Janssen were USD 2,998 million in 2019 compared to USD 2,025 million in 2018. The increase of USD 973 million, or 48%, was driven by the continued strong uptake of DARZALEX. Royalty income on net sales of DARZALEX was DKK 3,132 million in 2019 compared to DKK 1,708 million in 2018, an increase of DKK 1,424 million. The increase in royalties of 83% is higher than the increase in the underlying sales due to a combination of the change in roy-alty tiers in 2019 and positive currency fluctuations between the USD and DKK. REVENUE Genmab’s revenue was DKK 5,366 million in 2019 compared to DKK 3,025 million in 2018. The increase of DKK 2,341 mil-lion, or 77%, was mainly driven by higher DARZALEX royalties and milestones achieved under our daratumumab collabora-tion with Janssen. Split of Revenue (DKK million) 5,366 342 Novartis’ net sales of Arzerra were USD 17 million in 2019 compared to USD 26 million in 2018, a decrease of USD 9 million, or 35%. Royalty income on net sales of Arzerra was DKK 23 million in 2019 compared to DKK 33 million in 2018, a decrease of DKK 10 million, or 30%. The decrease in Arzerra net sales and resulting royalties was due to Novartis’ ongoing transition of Arzerra to limited availability in most jurisdictions. License Fees There was no license fee income during 2019. License fee income was DKK 348 million in 2018 which was driven by (i) the USD 50 million one-time payment from Novartis related to lost potential Arzerra milestones and royalties due to the transition of Arzerra to limited availability in most jurisdic-tions, under the Novartis ofatumumab collaboration, (ii) pay-ment from Janssen for additional DuoBody target pairs under the Janssen DuoBody collaboration and (iii) the payment 348 Royalties Milestone payments License Fees Reimbursement income Milestone Payments Milestone income was DKK 1,869 million in 2019 compared to DKK 687 million in 2018. The increase of DKK 1,182 million was mainly driven by higher DARZALEX milestone 2018 2019 Management’s Review / Financial Review 67 3,025 249 1,869 3,155 687 1,741

from Novo Nordisk for extending exclusivity of the commer-cial license for a DuoBody target pair under the Novo Nordisk DuoBody collaboration. General and administrative expenses accounted for 13% of the total operating expenses in 2019 and 2018. yield and level of investment in marketable securities in 2019 as compared to 2018. Please refer to note 4.2 for additional information regarding foreign currency risk and note 4.5 for additional information regarding the net financial items. OPERATING RESULT Operating income was DKK 2,638 million in 2019 compared to DKK 1,380 million in 2018. The increase of DKK 1,258 mil-lion, or 91%, was driven by higher revenue, which was partly offset by increased operating expenses. Reimbursement Income Reimbursement income, mainly comprised of the reimburse-ment of certain research and development costs related to the development work under Genmab’s collaboration agreements, amounted to DKK 342 million in 2019 compared to DKK 249 million in 2018. The increase of DKK 93 million, or 37%, was driven by reimbursement payments associated with our development activities relating to tisotumab vedotin under our collaboration with Seattle Genetics and the continued advancement of product candidates under our collaboration with BioNTech. CORPORATE TAX Corporate tax expense was DKK 693 million in 2019 compared to DKK 140 million in 2018, corresponding to an effective tax rate of 24% for 2019 and 9% in 2018. The effective tax rate increased in 2019 as the discrete tax benefit related to the reversal of valuation allowances on deferred tax assets for future taxable income was significantly higher in 2018 than 2019. In 2018, the discrete tax benefit was DKK 268 million as compared to DKK 29 million in 2019. Please refer to note 2.4 for additional information regarding the corporate tax and deferred tax assets including management’s significant judg-ments and estimates. NET FINANCIAL ITEMS The net financial items reflect a combination of interest in-come, unrealized and realized fair market value adjustments on our portfolio of marketable securities, as well as realized and unrealized foreign exchange adjustments. Financial income for 2019 was DKK 228 million, reflecting interest and other financial income of DKK 120 million, net re-alized and unrealized gains on marketable securities of DKK 9 million and net realized and unrealized exchange rate gains of DKK 99 million, as compared to DKK 243 million for 2018, reflecting interest and other financial income of DKK 63 mil-lion, net realized and unrealized gains on fair value hedges of DKK 2 million and net realized and unrealized exchange rate gains of DKK 178 million. OPERATING EXPENSES Total operating expenses increased by DKK 1,083 million, or 66%, from DKK 1,645 million in 2018 to DKK 2,728 million in 2019. NET RESULT Net result for 2019 was DKK 2,166 million compared to a net result of DKK 1,472 million in 2018. The increase of DKK 694 million, or 47%, was driven by the items described above. Research and Development Expenses Research and development expenses amounted to DKK 2,386 million in 2019 compared to DKK 1,431 million in 2018. The increase of DKK 955 million, or 67%, was driven by the advancement of tisotumab vedotin and enapotamab vedotin, the additional investment in our product pipeline, and the increase in research and development employees. CASH POSITION AND CASH FLOW Liquidity and Capital Resource Financial expenses for 2019 were DKK 7 million related to interest and other financial expenses, as compared to DKK 11 million for 2018 related to realized and unrealized losses on marketable securities. Cash Position 2019 2018 (DKK million) Research and development expenses accounted for 87% of the total operating expenses in 2019 and 2018. Cash and cash equivalents Marketable securities 3,552 7,419 533 5,573 As a result of the above, net financial items for 2019 were a net gain of DKK 221 million, as compared to a net gain of DKK 232 million for 2018. The decrease in net financial items was driven primarily by a decrease in net realized and unrealized exchange rate gains driven by foreign exchange movements which posi-tively impacted our U.S. dollar denominated portfolio and cash holdings to a greater extent in 2018 than 2019, partly offset by an increase in interest income due to the combination of higher Cash position 10,971 6,106 General and Administrative Expenses General and administrative expenses were DKK 342 million in 2019 compared to DKK 214 million in 2018. The increase of DKK 128 million, or 60%, was driven by growth across all support areas including enhanced technology and systems, early investment in commercial, and other areas due to the expansion of our product pipeline. As of December 31, 2019, Genmab’s cash, cash equivalents, and marketable securities (cash position) amounted to DKK 10,971 million. This represents a net increase of DKK 4,865 million, or 80%, from the beginning of 2018, which was mainly driven by net proceeds from the issuance of new shares in con-Management’s Review / Financial Review 68

nection with the public offering and listing of ADSs on the Nas-daq Global Select Market of DKK 3,635 million and our operat-ing income of DKK 2,638 million, which were partly offset by negative working capital adjustments of DKK 1,218 million re-lated to royalties and milestones achieved in the fourth quarter of 2019, which were receivables as of December 31, 2019. net financial items, and adjustments related to non-cash expenses, all of which may be highly variable period to period. In 2019, the primary driver of higher cash provided by operating activities was higher operating income. agreements and non-interest bearing receivables, which are due less than one year from the balance sheet date. The credit risk on receivables is considered to be limited. Please refer to note 3.5 for additional information regarding receivables. The change in cash used in investing activities primarily reflects differences between the proceeds received from sale and maturity of our investments and amounts invested. Purchases of marketable securities exceeded sales and maturities in both 2019 and 2018, which has resulted in significant growth in the marketable securities portion of the cash position. Shareholders’ equity as of December 31, 2019 equaled DKK 14,048 million compared to DKK 8,014 million at December 31, 2018. The increase was driven primarily by the issuance of shares and net income. On December 31, 2019, Genmab’s equity ratio was 93% compared to 95% as of December 31, 2018. As of December 31, 2019, DKK 3,552 million, as compared to DKK 533 million as of December 31, 2018, was held as cash and cash equivalents, and DKK 7,419 million, as compared to DKK 5,573 million as of December 31, 2018, was held as liquid investments in short-term government and other debt instruments. Net cash provided by financing activities is primarily related to the issuance of shares, purchase of treasury shares, exercise of warrants and lease payments. In 2019, the primary driver of the higher cash provided by financing activities was related to net proceeds from the issuance of new shares in connec-tion with the public offering and listing of ADSs on the Nasdaq Global Select Market of DKK 3,635 million, and purchase of treasury shares during 2018 of DKK 146 million. There were no purchases of treasury shares during 2019. We require cash to meet our operating expenses and capital expenditures. We have funded our cash requirements since our inception, including through December 31, 2019, pri-marily with equity financing, upfront payments and royalty and milestone payments from our partners. Cash and cash equivalents included short-term marketable securities of DKK 668 million at the end of December 2019. There were no short-term marketable securities included in cash and cash equivalents at the end of December 2018. In accordance with our accounting policy, securities purchased with a maturity of less than three months at the date of acquisition are classified as cash and cash equivalents. Marketable securities are invested in highly secure, liquid and conservative investments with short effective maturity. As of December 31, 2019, 91% of our marketable securities had a triple A-rating, compared to 90% at December 31, 2018. The weighted average effective duration was approxi-mately 1.1 years as of December 31, 2019 (2018: 1.4 years). Please refer to notes 4.2 and 4.4 for additional information regarding our financial risks and marketable securities. Cash Flow (DKK million) 2019 2018 Cash provided by (used in) operating activities 1,326 1,015 BALANCE SHEET As of December 31, 2019, total assets were DKK 15,144 million, compared to DKK 8,461 million as of December 31, 2018. As of December 31, 2019, the assets were mainly comprised of the cash position of DKK 10,971 million and receivables of DKK 3,001 million. The receivables consist primarily of royalties and milestones from our collaboration Cash provided by (used in) investing activities (1,983) (1,778) Cash provided by (used in) financing activities 3,660 (71) Net cash provided by operating activities is primarily related to our operating result, working capital fluctuations, reversal of Management’s Review / Financial Review 69

Management’s Review 70

Shareholders and Share Information OWNERSHIP Genmab is dual-listed on the Nasdaq Copenhagen A/S and the Nasdaq Global Select Market in the U.S. under the symbol GMAB. Our communication with the capital markets complies with the disclosure rules and regulations of these exchanges. As of December 31, 2019, the number of regis-tered shareholders totaled 65,525 shareholders holding a total of 63,264,793 shares, which represented 97.22% of the total share capital of 65,074,502. The following shareholders are registered in Genmab’s regis-ter of shareholders as being the owner of a minimum of 5% of the voting rights or a minimum of 5% of the share capital (one share equals one vote) as of December 31, 2019: Arti-san Partners Limited Partnership and BlackRock, Inc. Electronic shareholder communication enables Genmab to, among other things, quickly and efficiently call general meetings. The following chart illustrates the performance of the Genmab share during 2019 and the geographical distribution of our shareholders. With regard to the performance of Genmab’s ADSs, the public offering price on July 17, 2019 was USD 17.75. As of December 31, 2019 Genmab’s ADSs closed at USD 22.33. Please refer to note 4.7 for additional information regarding Genmab’s share capital including authorizations to issue shares and purchase its own shares. Shareholders registered in the company’s shareholder registry may sign up for electronic shareholder communica-tions via Genmab’s investor portal. The investor portal can be accessed at Genmab’s website www.genmab.com. Stock Performance Comparison 2019 (Index 100 = stock price on December 31, 2018) Geographical Shareholder Distribution* Index Genmab OMXC25 Index Nasdaq Biotech Index 2019 160 USA Denmark Switzerland UK Netherlands Luxembourg Belgium Other** 150 16% 1% 4% 2% 15% 140 1% 3% 2% 37% 39% 130 2018 13% 3% 3% 13% 120 26% 110 22% 100 90 * Based on figures from the internal shareholder register per December 31, 2018 and December 31, 2019. ** “Other” includes shares held in other countries and shares not held in nominee accounts, including OTC traded shares. 80 January February March April May June July August September October November December Management’s Review / Shareholders and Share Information 71

The following table shows share data as of December 31, 2019. Share data Denmark U.S. Number of shares at December 31,2019 61,797,002 3,277,500 (represented by 32,775,000 ADSs) Listing Nasdaq Copenhagen Nasdaq Global Select Market, New York Ticker Symbol GMAB GMAB Index Membership OMX Nordic Large Cap Index OMX Copenhagen Benchmark Index OMX Copenhagen 25 Index (OMX25) Nasdaq Biotech Index AMERICAN DEPOSITARY RECEIPT (ADR) PROGRAM Genmab has a sponsored Level 3 ADR program with Deutsche Bank Trust Company Americas. An ADS is a share certificate representing ownership of shares in a non-U.S. corporation. ADSs issued under Genmab’s ADR Program are quoted and traded in U.S. dollars on the Nasdaq Global Select Market in the United States. Ten Genmab ADSs correspond to one Genmab ordinary share. Genmab’s ADR ticker symbol is GMAB. For more information on Genmab’s ADR Program, visit https://ir.genmab.com/adr-program. Contact: Marisol Peron, Corporate Vice President, Communications and Investor Relations T: +1 609 524 0065; E: mmp@genmab.com For Investor Relations: Andrew Carlsen, Senior Director, Investor Relations T: +45 3377 9558; E: acn@genmab.com Annual General Meeting The annual general meeting will be held on March 26, 2020 at 2:00 PM local time at: Copenhagen Marriott Hotel Kalvebod Brygge 5 DK-1560 Copenhagen V INVESTOR RELATIONS (IR) Genmab’s Investor Relations and Communications depart-ment aims to ensure relevant, accurate and timely informa-tion is available to our investors and the financial commu-nity. We maintain an ongoing dialogue with sell-side equity analysts, as well as major institutional and retail sharehold-ers. A list of the current analysts covering Genmab can be found at our website along with financial reports, company announcements, current presentations, fact sheets and other downloads, plus information for private and institutional shareholders. Financial Calendar for 2020 Annual General Meeting 2020 Thursday, March 26, 2020 Publication of the Interim Report for the first quarter 2020 Wednesday, May 6, 2020 Publication of the Interim Report for the first half 2020 Wednesday, August 12, 2020 Publication of the Interim Report for the first nine months 2020 Wednesday, November 4, 2020 Management’s Review / Shareholders and Share Information 72

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Board of Mats Pettersson, B.Sc. Swedish, 74, Male Directors Board Chairman (Independent, elected by the General Meeting); Member of the Audit and Finance Committee First elected 2013, current term expires 2020 Special Competences Extensive experience from international research-based biotech and pharmaceutical companies. Founder and CEO of SOBI AB. Responsible for several transforming Business Development deals and member of various Executive man-agement committees at Pharmacia. Current Board Positions Member: Magle Chemoswed AB Management’s Review / Board of Directors 74

Deirdre P. Connelly Hispanic/American, 59, Female Anders Gersel Pedersen, M.D., Ph.D. Danish, 68, Male Pernille Erenbjerg Danish, 52, Female Deputy Chairman (Independent, elected by the General Meeting); Chairman of the Compensation Committee, Member of the Audit and Finance Committee, and the Nominating and Corporate Governance Committee First elected 2017, current term expires 2020 Board Member (Non-independent, elected by the General Meeting); Chairman of the Nominating and Corporate Governance Committee and Member of the Scientific Committee and the Compensation Committee First elected 2003, current term expires 2020 Board Member (Independent, elected by the General Meeting); Chairman of the Audit and Finance Committee, Member of the Nominating and Corporate Governance Committee First elected 2015, current term expires 2020 Special Competences More than 30 years’ experience as a corporate leader and extensive experience in corporate governance as a board member. Comprehensive experience with business turn-around, corporate culture transformation, product launch, and talent development. Successfully directed the launch of more than 20 new pharmaceutical drugs. Former Presi-dent, North America Pharmaceuticals for GlaxoSmithKline. Special Competences Business and management experience in the pharma-ceutical industry, including expertise in clinical research, development, regulatory affairs and product life cycle management. Former Executive Vice President of Research & Development of H. Lundbeck A/S. Special Competences Senior executive management and broad business experi-ence from the telecoms, media and tech industries. Exten-sive experience with transformation of large and complex companies, including digital transformations and digitally based innovation. Comprehensive all round background within finance including extensive exposure to stock mar-kets, equity and debt investors. Certified Public Accountant background (no longer practicing). Responsible for major transformation processes in complex organizations includ-ing M&A. Former CEO and President of TDC A/S. Due to her experience and background within accounting, Pernille Erenbjerg qualifies as an audit committee financial expert. Current Board Positions Chairman: Aelis Farma Deputy Chairman: Bavarian Nordic A/S Member: Hansa Medical AB, Bond 2 development 2 GP limited Current Board Positions Member: Macy’s Inc. and Lincoln National Corporation Current Board Positions Deputy Chair: Millicom Member: Nordea AB Chair of Remuneration Committee: Millicom Audit Committee Member: Millicom, Nordea AB Operations and Sustainability Committee Member: Nordea AB Management’s Review / Board of Directors 75

Paolo Paoletti, M.D. Italian (U.S. Citizen), 69, Male Rolf Hoffmann German, 60, Male Peter Storm Kristensen Danish, 45, Male Board Member (Independent, elected by the General Meeting); Chairman of the Scientific Committee, and Member of the Compensation Committee First elected 2015, current term expires 2020 Board Member (Independent, elected by the General Meeting); Member of the Audit and Finance Committee, and the Scientific Committee First elected 2017, current term expires 2020 Board Member (Non-independent, elected by the employees) First elected 2016, current term expires 2022 Special Competences Broad legal experience within the pharmaceutical indus-try with specialty in corporate law, securities law, human resources law as well as drafting and negotiating contracts in general. Special Competences Extensive experience in research, development and com-mercialization in the pharmaceutical industry. Successfully conducted submissions and approvals of new cancer drugs and new indications in the USA and in Europe. Responsible for seven new medicines for cancer patients during his 10 years at GlaxoSmithKline and one new can-cer medicine during his time at Eli Lilly. Special Competences Extensive international management experience with exper-tise in creating and optimizing commercial opportunities in global markets. Additional expertise in P&L management, governance and Corporate Integrity Agreement Manage-ment, compliance and organizational efficiency. Over 20 years’ experience in the international pharmaceutical and biotechnology industries at Eli Lilly and Amgen. Current Position, Including Managerial Positions Associate Director, Legal at Genmab Current Position, Including Managerial Positions Acting CEO for GammaDelta Therapeutics Limited Current Position, Including Managerial Positions Adjunct Professor Strategy and Entrepreneurship, University of North Carolina Business School Current Board Positions Member: PsiOxus Therapeutics Limited, FORMA Therapeutics Current Board Positions Chairman: Biotest AG Member: Trizell Ltd., EUSA Pharma, Inc., Paratek Pharmaceuticals, Inc. and Shield Therapeutics plc Management’s Review / Board of Directors 76

Mijke Zachariasse, Ph.D. Dutch, 46, Female Daniel J. Bruno American, 40, Male Board Member (Non-independent, elected by the employees) First elected 2019, current term expires 2022 Board Member (Non-independent, elected by the employees) First elected 2016, current term expires 2022 Special Competences Broad experience in people and business management in the natural sciences sector. Specific expertise in building strategic partnerships across sectors, financial and fund management, and setting research strategies in the aca-demic sector. Special Competences Certified Public Accountant background with extensive knowledge and experience in finance, technical account-ing, corporate tax, and financial reporting in the life sciences industry. Current Position, Including Managerial Positions Vice President, Corporate Controller at Genmab Current Position, including Managerial Positions Director, Protein Production and Chemistry at Genmab Management’s Review / Board of Directors 77

Senior Leadership Jan G. J. van de Winkel, Ph.D. Dutch, 58, Male David A. Eatwell British (U.S. Citizen), 59, Male Judith Klimovsky, M.D. Argentinian (U.S. Citizen), 63, Female Birgitte Stephensen Danish, 59, Female Michael K. Bauer, Ph.D. German, 56, Male President & Chief Executive Officer Executive Vice President & Chief Financial Officer Senior Vice President, IPR & Legal Senior Vice President, Head of R&D Operations Executive Vice President & Chief Development Officer Special Competences Extensive antibody creation and development expertise, broad knowledge of the biotechnology industry and executive manage-ment skills. Special Competences Intellectual property and legal ex-pertise in the biotechnology field. Special Competences Broad international experience in finance, strategy and business management and in-depth know-ledge of the pharmaceutical and biotechnology industries. Special Competences Wide, international scientific and pharmaceutical industry back-ground; significant experience in clinical drug development; cross-functional and cross-cultural strategic leadership. Special Competences Extensive expertise in oncology drug development from early clinical stages through to market-ing approval, experience in clinical practice and leading large teams in pharmaceutical organizations. Current Board Positions Chairman: Hookipa Pharma Member: Leo Pharma, Celdara Medical Scientific Advisory Board: Thuja Capital Healthcare Fund Advisory Board: Capricorn Health-tech Fund Current Board Positions Member: Belllicum Pharmaceuticals Management’s Review / Senior Leadership 78

Tahamtan Ahmadi, M.D., Ph.D. Iranian-German (U.S. Citizen), 47, Male Anthony Pagano American, 42, Male Martine J. van Vugt, Ph.D. Dutch, 49, Female Senior Vice President, Finance and Corporate Development Senior Vice President, Chief of Staff Senior Vice President, Head of Oncology Special Competences Significant knowledge and experi-ence in the life sciences industry particularly as relates to corporate finance, corporate development, strategic planning, general man-agement, treasury, accounting and corporate governance. Special Competences Extensive knowledge and expe-rience in portfolio, project and alliance management, identifying and leading corporate strategic initiatives, and business devel-opment operations and strategy related to corporate transactions and licensing. Special Competences Significant expertise in global reg-ulatory and clinical drug develop-ment across entire spectrum from pre-IND to life cycle management; drug discovery and translational research. Management’s Review / Senior Leadership 79

Financial Statements Financial Statements 80

Introduction The financial statements in the 2019 annual report are grouped into six sections: Primary Statements; Basis of Presentation; Results for the Year; Operating Assets and Liabilities; Capital Structure, Financial Risk and Related Items; and Other Disclosures. Each note to the financial statements includes information about the accounting policies applied and significant management judgments and estimates in addition to the financial numbers. Financial Statements 81

Table of Contents Financial Statements Primary Statements Section 3 Section 5 Operating Assets and Liabilities Other Disclosures Consolidated Statements of Comprehensive Income ....... 83 3.1Intangible Assets................................................. 101 Remuneration of the Board of Directors 5.1 Consolidated Balance Sheets.......................................... 84 Consolidated Statements of Cash Flows .......................... 85 Consolidated Statements of Changes in Equity................ 86 3.2Property, Plant and Equipment ............................ 104 3.3Leases................................................................. 105 3.4Other Investments ............................................... 106 3.5Receivables ......................................................... 107 3.6Provisions ........................................................... 107 3.7Other Payables .................................................... 108 and Executive Management ................................. 125 Related Party Disclosures .................................... 134 Company Overview .............................................. 134 Commitments ...................................................... 134 Contingent Assets, Contingent Liabilities and Subsequent Events ....................................... 134 Fees to Auditors Appointed at the Annual General Meeting ................................ 135 5.2 5.3 5.4 5.5 Section 1 Basis of Presentation 5.6 1.1Nature of the Business and Accounting Policies ..... 87 1.2New Accounting Policies and Disclosures............... 90 1.3Management’s Judgments and Estimates under IFRS ............................................................. 91 Adjustments related to Cash Flow Statement ....... 136 Collaborations and Technology Licenses .............. 136 Section 4 5.7 5.8 Capital Structure, Financial Risk and Related Items Capital Management............................................ 109 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Financial Risk ...................................................... 110 Financial Assets and Liabilities ............................ 113 Marketable Securities .......................................... 115 Financial Income and Expenses ........................... 117 Share-Based Instruments .................................... 118 Share Capital....................................................... 123 Section 2 Results for the Year 2.1Revenue ................................................................ 93 2.2Information about Geographical Areas ................... 95 2.3Staff Costs ............................................................. 96 2.4Corporate and Deferred Tax.................................... 98 2.5Result Per Share .................................................. 100 Financial Statements / Table of Contents 82

Primary Income Statement (DKK million) Note 2019 2018 SCotantseomlideanttesd 2.1, 2.2 Revenue 5,366 3,025 Research and development expenses General and administrative expenses 2.3, 3.1, 3.2 2.3, 3.2 (2,386) (342) (1,431) (214) Statements of Comprehensive Income Operating expenses (2,728) (1,645) Operating result 2,638 1,380 Financial income 4.5 228 243 Financial expenses 4.5 (7) (11) Net result before tax 2,859 1,612 Corporate tax 2.4 (693) (140) Net result 2,166 1,472 Basic net result per share Diluted net result per share 2.5 2.5 34.40 34.03 24.03 23.73 Statement of Comprehensive Income Net result 2,166 1,472 Other comprehensive income: Amounts which will be re-classified to the income statement: Adjustment of foreign currency fluctuations on subsidiaries 6 10 Total comprehensive income 2,172 1,482 Financial Statements / Primary Statements 83

Primary Assets December 31, 2019 December 31, 2018 (DKK million) Note SCotantseomliednattsed Balance Sheets Intangible assets Property, plant and equipment Right-of-use assets Receivables Deferred tax assets Other investments 2.2, 3.1 2.2, 3.2 3.3 3.5 2.4 3.4 470 237 177 11 139 149 470 162 – 10 386 – Total non-current assets 1,183 1,028 Receivables Marketable securities Cash and cash equivalents 3.5 4.4 2,990 7,419 3,552 1,327 5,573 533 Total current assets 13,961 7,433 Total assets 15,144 8,461 Shareholders’ Equity and Liabilities December 31, 2019 December 31, 2018 (DKK million) Note Share capital Share premium Other reserves Retained Earnings 4.7 4.7 65 11,755 98 2,130 61 8,059 92 (198) Total shareholders’ equity 14,048 8,014 Provisions Lease liabilities Other payables 3.6 3.3 3.7 2 155 1 1 – 2 Total non-current liabilities 158 3 Corporate tax payable Lease liabilities Other payables 2.4 3.3 3.7 73 26 839 128 – 316 Total current liabilities 938 444 Total liabilities 1,096 447 Total shareholders’ equity and liabilities 15,144 8,461 Financial Statements / Primary Statements 84

Primary Statements of Cash Flows (DKK million) Note 2019 2018 SCotantseomliednattsed Cash flows from operating activities: Net result before tax Reversal of financial items, net Adjustment for non-cash transactions Change in working capital 2,859 (221) 291 (1,218) 1,612 (232) 179 (634) 4.5 5.7 5.7 Statements of Cash Flows Cash generated by operating activities before financial items Interest received Interest elements of lease payments Interest paid Corporate taxes (paid)/received 1,711 111 (7) (13) (476) 925 44 – – 46 3.3 Net cash generated by operating activities 1,326 1,015 Cash flows from investing activities: Investment in intangible assets Investment in tangible assets Marketable securities bought Marketable securities sold 3.1 3.2 4.4 (32) (79) (5,812) 3,940 (406) (72) (3,521) 2,221 Net cash used in investing activities (1,983) (1,778) Cash flows from financing activities: Warrants exercised Shares issued for cash Costs related to issuance of shares Principal elements of lease payments Purchase of treasury shares Payment of withholding taxes on behalf of employees on net settled RSUs 65 3,873 (238) (31) – (9) 75 – – – (146) – 3.3 Net cash from financing activities 3,660 (71) Changes in cash and cash equivalents Cash and cash equivalents at the beginning of the period Exchange rate adjustments 3,003 533 16 (834) 1,348 19 Cash and cash equivalents at the end of the period 3,552 533 Cash and cash equivalents include: Bank deposits and petty cash Short-term marketable securities 2,884 668 533 – Cash and cash equivalents at the end of the period 3,552 533 Financial Statements / Primary Statements 85

Primary Statements of Changes in Equity Share Share Translation Retained Shareholders’ (DKK million) Capital Premium Reserves Earnings Equity SCotantseomliednattsed Statements Balance at December 31, 2017 Change in accounting policy: Adoption of IFRS 15 61 – 7,984 – 82 – (1,855) 151 6,272 151 Adjusted total equity at January 1, 2018 61 7,984 82 (1,704) 6,423 Net result Other comprehensive income – – – – – 10 1,472 – 1,472 10 of in Changes Equity Total comprehensive income Transactions with owners: Exercise of warrants Purchase of treasury shares Share-based compensation expenses Tax on items recognized directly in equity – – 10 1,472 1,482 – – – – 75 – – – – – – – – (146) 91 89 75 (146) 91 89 Balance at December 31, 2018 61 8,059 92 (198) 8,014 Net result Other comprehensive income – – – – – – – 6 6 2,166 – 2,166 2,166 6 2,172 Total comprehensive income Transactions with owners: Exercise of warrants Shares issued for cash Expenses related to capital increases Share-based compensation expenses Net settlement of RSUs Tax on items recognized directly in equity 1 3 – – – – 64 3,870 (238) – – – – – – – – – – – – 147 (9) 24 65 3,873 (238) 147 (9) 24 Balance at December 31, 2019 65 11,755 98 2,130 14,048 Financial Statements / Primary Statements 86

SBeacstisioonf 1 Presentation 3.2 Property, Plant and Equipment 1.1 Nature of the Business and Accounting Policies 3.3 Leases 3.4 Other Investments 3.5 Receivables Genmab A/S is a publicly traded, international biotechnology company specializing in the creation and development of dif-ferentiated antibody therapeutics for the treatment of cancer and other diseases. Founded in 1999, the company has two approved antibodies, a broad clinical and pre-clinical product pipeline and proprietary next generation antibody technologies. 3.6 Provisions 3.7 Other Payables Section 4 – Capital Structure, Financial Risk and Related Items This section describes Genmab’s financial accounting policies in-cluding management’s judgments and estimates under International Financial Reporting Standards (IFRS). New or revised EU endorsed accounting standards and interpre-tations are described, in addition to how these changes are expected to impact the financial performance and reporting of the Genmab Group. 4.3 Financial Assets and Liabilities 4.4 Marketable Securities The financial statements have been prepared in accordance with IFRS as issued by the International Accounting Standards Board (IASB), and with the IFRS as endorsed by the EU and additional Danish disclosure requirements for annual reports of listed companies. Except as outlined in note 1.2, the finan-cial statements have been prepared using the same account-ing policies as 2018. 4.5 Financial Income and Expenses Section 5 – Other Disclosures 5.5 Contingent Assets, Contingent Liabilities and Subsequent Events Materiality The group’s annual report is based on the concept of mate-riality and the group focuses on information that is consid-ered material and relevant to the users of the consolidated financial statements. The consolidated financial statements consist of a large number of transactions. These transactions are aggregated into classes according to their nature or func-tion and presented in classes of similar items in the consol-idated financial statements as required by IFRS and Danish disclosure requirements for listed companies. If items are individually immaterial, they are aggregated with other items of similar nature in the financial statements or in the notes. Please refer to the overview below to see in which note/sec-tion the detailed accounting policy is included. Genmab describes the accounting policies in conjunction with each note with the aim to provide a more understandable description of each accounting area. The description of the accounting policies in the notes is part of the complete description of Genmab’s accounting policies. Accounting Policies Section 2 – Results for the Year 2.1 Revenue 2.2 Information about Geographical Areas 2.3 Staff Costs 2.4 Corporate and Deferred Tax The disclosure requirements are substantial in IFRS and for Danish listed companies. The group provides these specific required disclosures unless the information is considered immaterial to the economic decision-making of the readers of the financial statements or not applicable. 2.5 Result per Share Section 3 – Operating Assets and Liabilities 3.1 Intangible Assets Financial Statements / Basis of Presentation 87

1.1 Accounting Policies – Continued and support functions including human resources, informa-tion technology and the finance departments. In addition, depreciation and impairment of intangible assets and prop-erty, plant and equipment, to the extent such expenses are related to administrative functions are also included. General and administrative expenses are recognized in the income statement in the period to which they relate. Consolidated Financial Statements The consolidated financial statements include Genmab A/S (the parent company) and subsidiaries over which the parent company has control. The parent controls a subsidi-ary when the parent is exposed to, or has rights to, variable returns from its involvement with the subsidiary and has the ability to affect those returns through its power to direct the activities of the subsidiary. A company overview is included in note 5.3. Functional and Presentation Currency The financial statements have been prepared in Danish Kro-ner (DKK), which is the functional and presentation currency of the parent company. Foreign Currency Transactions in foreign currencies are translated at the exchange rates in effect at the date of the transaction. Statement of Cash Flow The cash flow statement is presented using the indirect method with basis in the net result before tax. Exchange rate gains and losses arising between the trans-action date and the settlement date are recognized in the income statement as financial items. The group’s consolidated financial statements have been prepared on the basis of the financial statements of the par-ent company and subsidiaries – prepared under the group’s accounting policies – by combining similar accounting items on a line-by-line basis. On consolidation, intercompany in-come and expenses, intercompany receivables and payables, and unrealized gains and losses on transactions between the consolidated companies are eliminated. Cash flow from operating activities is stated as the net result adjusted for net financial items, non-cash operating items such as depreciation, amortization, impairment losses, share-based compensation expenses, provisions, and for changes in working capital, interest paid and received, and corporate tax-es paid. Working capital mainly comprises changes in receiv-ables, provisions paid and other payables excluding the items included in cash and cash equivalents. Changes in non-current assets and liabilities are included in working capital, if related to the main revenue-producing activities of Genmab. Unsettled monetary assets and liabilities in foreign cur-rencies are translated at the exchange rates in effect at the balance sheet date. Exchange rate gains and losses arising between the transaction date and the balance sheet date are recognized in the income statement as financial items. The recorded value of the equity interests in the consolidated subsidiaries is eliminated with the proportionate share of the subsidiaries’ equity. Subsidiaries are consolidated from the date when control is transferred to the group. Classification of Operating Expenses in the Income Statement Research and Development Expense Research and development expenses primarily include salaries, benefits and other employee related costs of our research and development staff, license costs, manufactur-ing costs, pre-clinical costs, clinical trials, contractors and outside service fees, amortization of licenses and rights, and depreciation and impairment of intangible assets and prop-erty, plant and equipment, to the extent that such costs are related to the group’s research and development activities. Please see note 3.1 for a more detailed description on the treatment of Genmab’s research and development expenses. Cash flow from investing activities is comprised of cash flow from the purchase and sale of intangible assets and property, plant and equipment and financial assets as well as purchase and sale of marketable securities. The income statements for subsidiaries with a different function-al currency than the group presentation currency are translated into the group’s presentation currency at the year’s weighted average exchange rate, and the balance sheets are translated at the exchange rate in effect at the balance sheet date. Cash flow from financing activities is comprised of cash flow from the issuance of shares, if any, and payment of long-term loans including installments on lease liabilities. Finance lease transactions are considered non-cash transactions. Exchange rate differences arising from the translation of foreign subsidiaries shareholders’ equity at the beginning of the year and exchange rate differences arising as a result of foreign subsidiaries’ income statements being translat-ed at average exchange rates are recorded in translation reserves in shareholders’ equity. Cash and cash equivalents comprise cash, bank deposits, and marketable securities with a maturity of three months or less on the date of acquisition. General and Administrative Expense General and administrative expenses relate to the manage-ment and administration of the group. This includes salaries, benefits and other headcount costs related to management Financial Statements / Basis of Presentation 88

1.1 Accounting Policies – Continued The cash flow statement cannot be derived solely from the financial statements. relating to the ineffective portion and changes in time value of the derivative instrument is recognized immediately in the income statement within financial income or expenses. as this would require unanimous consent of both parties on decisions related to the relevant activities. Under these agreements, joint clinical development may be selected on a product by product basis and would result in development cost and product ownership being shared equally going forward. These agreements also include provisions which will allow the parties to opt out of joint development at key points along the development timeline. An opt out by one of the parties would result in loss of joint control by the opt out party and the other party is entitled to continue developing the product on predetermined licensing terms. Derivative Financial Instruments and Hedging Activities Derivatives are initially recognized at fair value on the date a derivative contract is entered into and are subsequently re-mea-sured at their fair value. The method of recognizing the resulting gain or loss depends on whether the derivative is designated as a hedging instrument, and if so, the nature of the item being hedged. Genmab designates certain derivatives as either: When forward contracts are used to hedge forecast transac-tions, Genmab generally designates the full change in fair value of the forward contract (including forward points) as the hedging instrument. In such cases, the gains or losses relating to the effective portion of the change in fair value of the entire forward contract are recognized in the cash flow hedge reserve within equity. 1. Fair value hedge (hedges of the fair value of recognized assets or liabilities or a firm commitment); or 2. Cash flow hedge (hedges of a particular risk associated with a recognized asset or liability or a highly probable forecast transaction). Changes in the fair value of derivatives that are designated and qualify as fair value hedges are recorded in the income state-ment, together with any changes in the fair value of the hedged asset or liability that is attributable to the hedged risk. During 2017, Seattle Genetics exercised its option to co-de-velop and co-commercialize tisotumab vedotin. All costs and profits for tisotumab vedotin will be shared on a 50:50 basis and joint control exists over the relevant activities. Accordingly, only the tisotumab vedotin collaboration with Seattle Genetics is considered a joint operation under IFRS At the inception of a transaction, Genmab documents the relationship between hedging instruments and hedged items, as well as its risk management objectives and strategy for undertaking various hedging transactions. Genmab also documents its assessment, both at hedge inception and on an ongoing basis, of whether the derivatives that are used in hedging transactions are highly effective in offsetting chang-es in fair values or cash flows of hedged items. Treasury Shares The total amount paid to acquire treasury shares including directly attributable costs and the proceeds from the sale of treasury shares are recognized in retained earnings. 11, “ t Arrangements.” Revenues, expenses, receivables, Join and payables in connection with our collaboration agree-ments are included in the related financial statement lines and footnotes. Collaboration Agreements The group has entered into various collaboration agreements, primarily in connection with the group’s research and devel-opment projects and the clinical testing of product candi-dates. The collaboration agreements are structured such that each party contributes its respective skills in the various phases of the development project and contain contractual terms regarding sharing of control over the relevant activities under the agreement. No joint control exists for the group’s collaborations with Janssen and Novartis as they retain final decision making authority over the relevant activities. During December 2019, Genmab entered into a research collaboration and license agreement with CureVac AG. The strategic partnership will focus on the research and devel-opment of differentiated mRNA-based antibody products by combining CureVac’s mRNA technology and know-how with Genmab’s proprietary antibody technologies and expertise. Movements on the hedging reserve in other comprehensive income are shown as part of the statement of shareholders’ equity. The full fair value of a hedging derivative is classi-fied as a non-current asset or liability when the remaining maturity of the hedged item is more than 12 months and as a current asset or liability when the remaining maturity of the hedged item is less than 12 months. Under the terms of the agreement Genmab will provide CureVac with a USD 10 million upfront payment. The compa-nies will collaborate on research to identify an initial product candidate and CureVac will contribute a portion of the overall costs for the development of this product candidate, up to the time of an Investigational New Drug Application. Genmab would thereafter be fully responsible for the development The effective portion of changes in the fair value of deriva-tives that are designated and qualify as cash flow hedges is recognized in other comprehensive income. The gain or loss The group’s collaboration agreements with BioNTech may become subject to joint control if product candidates under the agreements are selected for joint clinical development Financial Statements / Basis of Presentation 89

1.1 Accounting Policies – Continued and commercialization of the potential product, in exchange for undisclosed milestones and tiered royalties to CureVac. The agreement also includes three additional options for Genmab to obtain commercial licenses to CureVac’s mRNA technology at pre-defined terms, exercisable within a five-year period. If Genmab exercises any of these options, it would fund all research and would develop and commercial-ize any resulting product candidates with CureVac eligible to receive between USD 275 million and USD 368 million in de-velopment, regulatory and commercial milestone payments for each product, dependent on the specific product concept. In addition, CureVac is eligible to receive tiered royalties in the range from mid-single digits up to low double digits per product. CureVac would retain an option to participate in de-velopment and/or commercialization of one of the potential additional programs under pre-defined terms and conditions. Further, Genmab made a EUR 20 million equity investment in CureVac. Refer to note 3.4 for additional information regard-ing Genmab’s equity investment in CureVac. 1.2 Lease terms are negotiated on an individual basis and con-tain a wide range of different terms and conditions. New Accounting Policies and Disclosures Assets and liabilities arising from a lease are initially mea-sured on a present value basis. Lease liabilities include the net present value of fixed payments, less any lease incen-tives. As our leases do not provide an implicit rate, we use our incremental borrowing rate based on the information available at commencement date in determining the present value of lease payments. Our lease terms may include op-tions to extend or terminate the lease when it is reasonably certain that we will exercise that option. In determining the lease term, management considers all facts and circumstanc-es that create an economic incentive to exercise an extension option, or not exercise a termination option. Extension op-tions (or periods after termination options) are only included in the lease term if the lease is reasonably certain to be extended (or not terminated). New Accounting Policies and Disclosures for 2019 Genmab has, with effect from January 1, 2019, implement-ed the amendments to IFRS 9, IAS 19, IAS 28, IFRIC 23 and annual improvements to IFRSs 2015-2017. The implementa-tion of these standards has not had a material impact on the entity in the current reporting period. Genmab has, with effect from January 1, 2019, implement-ed IFRS 16. The impact of the adoption of the standard is described below. Effective January 1, 2019, we adopted IFRS 16 using the mod-ified retrospective transition method. Under this method, all leases are recognized in the balance sheet as a right-of-use (“ROU”) asset with a corresponding lease liability, except for short term assets in which the lease term is 12 months or less, or low value assets. ROU assets represent our right to use an underlying asset for the lease term and lease liabili-ties represent our obligation to make lease payments arising from the lease. The ROU asset is depreciated over the shorter of the asset’s useful life and the lease term on a straight-line basis over the lease term. In the income statement, lease costs are replaced by depreciation of the ROU asset recognized over the lease term in operating expenses, and interest expenses related to the lease liability are classified in financial items. The comparative information has not been restated and continues to be reported under the accounting standards in effect for those periods. ROU assets are measured at cost and include the amount of the initial measurement of lease liability, any lease payments made at or before the commencement date less any lease incentives received, any initial direct costs, and restoration costs. Payments associated with short-term leases and leases of low-value assets are recognized on a straight-line basis as an expense in the income statement. Short-term leases are leases with a lease term of 12 months or less and low-value assets comprise IT equipment and small items of office furniture. On adoption of IFRS 16, the group recognized lease liabili-ties in relation to leases that had previously been classified as ‘operating leases’ under the principles of IAS 17 Leases. These liabilities were measured at the present value of the remaining lease payments, discounted using the lessee’s Genmab determines if an arrangement is a lease at inception. Genmab leases various properties and IT equipment. Rental contracts are typically made for fixed periods. Financial Statements / Basis of Presentation 90

1.2 New Accounting Policies and Disclosures – Continued incremental borrowing rate as of January 1, 2019. The weight-ed average lessee’s incremental borrowing rate applied to the lease liabilities on January 1, 2019 was 3.7%. • excluded initial direct costs for the measurement of the ROU assets at the date of initial application Accounting estimates are based on historical experience and various other factors relative to the circumstances in which they are applied. Estimates are generally made based on information available at the time. An example would include management’s estimation of deferred income tax assets. There are no ROU assets that meet the definition of invest-ment property. The impact of the adoption of IFRS 16 on the financial state-ments as of January 1, 2019 is shown in the table and further described below: Accounting judgments are made in the process of apply-ing Genmab’s accounting policies. These judgements are typically made based on the guidance and information available at the time of application. Examples would include management’s judgements utilized in determining revenue recognition. New Accounting Policies and Disclosures Effective in 2020 or Later The IASB has issued, and the EU has endorsed, a number of new standards and updated some existing standards, the majority of which are effective for accounting periods beginning on January 1, 2020 or later. Therefore, they are not incorporated in the consolidated financial statements. There are no standards that are not yet effective and that would be expected to have a material impact on the entity in the current or future reporting periods and on foreseeable future transactions. January 1, 2019 (DKK million) Operating lease commitments disclosed as at December 31, 2018 Discounted using the group’s incremental borrowing rate of 3.7% (Less): short-term leases recognized on a straight-line basis as expense Add/(less): adjustments as a result of a different treatment of extension and termination options 184 These estimates and judgments may prove incomplete or in-correct, and unexpected events or circumstances may arise. The Genmab group is also subject to risks and uncertainties which may lead actual results to differ from these estimates, both positively and negatively. Specific risks for the Genmab group are discussed in the relevant section of the manage-ment’s review and in the notes to the financial statements. (42) (3) 66 Lease liability recognized at January 1, 2019 205 1.3 Management’s Judgments and Estimates under IFRS The areas involving a high degree of judgment and estimation that are significant to the financial statements are summa-rized below. Refer to the identified notes for further informa-tion on the key accounting estimates and judgements utilized in the preparation of the consolidated financial statements. The ROU assets established at January 1, 2019 on the balance sheet was DKK 205 million. Net result decreased by DKK 4 million as a result of adopting IFRS 16 in 2019. Cash flows from operating activities increased by DKK 35 million and cash flows from financing activities decreased by DKK 31 million as a result of adopting IFRS 16 in 2019. In preparing financial statements under IFRS, certain provi-sions in the standards require management’s judgments, including various accounting estimates and assumptions. These affect the application of accounting policies, as well as reported amounts within the financial statements and disclosures. 2.1 Recognition of revenue For purposes of applying the modified retrospective approach in adoption of IFRS 16, Genmab has used the following prac-tical expedients permitted by the standard: 2.3 Valuation assumptions in Black-Scholes pricing model 2.4 Estimation of current and deferred income taxes Determining the carrying amount of some assets and liabil-ities requires judgments, estimates and assumptions con-cerning future events that are based on historical experience and other factors, which by their very nature are associated with uncertainty and unpredictability. 3.1 Estimated useful life of intangible assets • applied the exemption not to recognize ROU assets and liabilities for leases with less than 12 months of lease term from January 1, 2019, and 3.1 Capitalization of research and development costs Financial Statements / Basis of Presentation 91

Financial Statements 92

2.1 Revenue SRescutilotsn 2 2.1 Revenue for the Year (DKK million) 2019 2018 Revenue: Royalties Milestone payments License fees Reimbursement income 3,155 1,869 – 342 1,741 687 348 249 This section includes disclosures related to revenue, information about geographical areas, staff costs, taxation and result per share. A detailed description of the results for the year is provided in the Financial Review section in the Management’s Review. Total 5,366 3,025 Revenue split by collaboration partner: Janssen (DARZALEX/daratumumab & DuoBody) Novartis (Arzerra/ofatumumab) Other collaboration partners 4,983 23 360 2,390 338 297 Total 5,366 3,025 Research and development costs are described in note 3.1. Revenue may vary from period to period as revenue compris-es royalties, milestone payments, license fees and reim-bursement of certain research and development costs under Genmab’s collaboration agreements. five-step model to contracts when it is probable that the entity will collect the consideration it is entitled to in exchange for the goods or services it transfers to the customer. At contract inception, once the contract is determined to be within the scope of IFRS 15, we assess the goods or services promised within each contract and identify, as a performance obligation, and assess whether each promised good or service is distinct. We then recognize as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. Accounting Policies Genmab recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration that the entity expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements that Genmab determines are within the scope of IFRS 15, Genmab performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obliga-tions in the contract; and (v) recognize revenue when (or as) the entity satisfies a performance obligation. We only apply the Royalties: License and collaboration agreements include sales-based royalties including commercial milestone payments based on the level of sales. The license has been deemed to be the predominant item to which the royalties relate under our license and collaboration agreements. As a result, Genmab recognizes revenue when the related sales occur. Financial Statements / Results for the Year 93

2.1 Revenue – Continued Milestone Payments: At the inception of each arrangement that includes milestone payments, Genmab evaluates whether the achievement of milestones are considered highly probable and estimates the amount to be included in the transaction price using the most likely amount method. If it is highly probable that a significant revenue reversal would not occur, the associated milestone value is included in the transaction price. Milestone payments that are not within the control of Genmab or the license and collaboration partner, such as regulatory approvals, are not considered probable of being achieved until those approvals are received. The transaction price is then allocated to each performance obligation on a relative stand-alone selling price basis, for which Genmab recognizes revenue as or when the performance obligations under the contract are satisfied. At the end of each subse-quent reporting period, Genmab re-evaluates the probability of achievement of such development milestones and any related constraint, and if necessary, adjusts its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect revenue and earnings in the period of adjustment. Under all of Genmab’s existing license and collaboration agreements, milestone pay-ments have been allocated to the license transfer performance obligation. recognizing revenue from non-refundable, upfront fees. Under all of Genmab’s existing license and collaboration agree-ments the license to functional intellectual property has been determined to be distinct from other performance obligations identified in the agreement. Reimbursement Income for R&D Services: License and collab-oration agreements include the reimbursement or cost sharing for research and development services and payment for FTEs at contractual rates. R&D services are performed and satisfied over time given that the customer simultaneously receives and consumes the benefits provided by Genmab and revenue for R&D services is recognized over time rather than a point in time. Management’s Judgments and Estimates Evaluating the criteria for revenue recognition under license and collaboration agreements requires management’s judgement to assess and determine the following: • The nature of performance obligations and whether they are distinct or should be combined with other performance obligations to determine whether the performance obligations are satisfied over time or at a point in time. License Fees for Intellectual Property: If the license to Genmab’s functional intellectual property is determined to be distinct from the other performance obligations identified in the arrangement, Genmab recognizes revenues from non-re-fundable upfront fees allocated to the license at the point in time the license is transferred to the licensee and the licensee is able to use and benefit from the license. For licenses that are bundled with other promises, Genmab utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of • An assessment of whether the achievement of milestone payments is highly probable. • The stand-alone selling price of each performance obliga-tion identified in the contract using key assumptions which may include forecasted revenues, development timelines, reimbursement rates for personnel costs, discount rates and probabilities of technical and regulatory success. Financial Statements / Results for the Year 94

2.2 Information about Geographical Areas 2.2 Information about Geographical Areas The Genmab group is managed and operated as one busi-ness unit, which is reflected in the organizational structure and internal reporting. No separate lines of business or separate business entities have been identified with respect to any of the product candidates or geographical markets and no segment information is currently disclosed in the internal reporting. Accounting Policies Geographical information is presented for the Genmab group’s revenue and non-current assets. Revenue is attribut-ed to countries on the basis of the location of the legal entity holding the contract with the counterparty and operations. Non-current assets comprise intangible assets and property, plant and equipment. Accordingly, it has been concluded that it is not relevant to include segment disclosures in the financial statements as the group’s business activities are not organized on the basis of differences in related product and geographical areas. Non-current Assets Non-current Assets Revenue Revenue (DKK million) 2019 2018 Denmark Netherlands USA Japan 5,366 – – – 387 252 68 – 3,025 – – – 454 167 11 – Total 5,366 707 3,025 632 Financial Statements / Results for the Year 95

2.3 Staff Costs 2.3 Staff Costs Government grants, which are a reduction of payroll taxes in the Netherlands, amounted to DKK 96 million in 2019 and DKK 86 million in 2018. These amounts are an offset to wages and salaries and research and development costs in the table above. The increase in 2019 was primarily due to in-creased research activities in the Netherlands combined with a higher level of grants provided by the Dutch government. (DKK million) 2019 2018 Wages and salaries Share-based compensation Defined contribution plans Other social security costs Government grants 489 147 39 72 (96) 308 91 24 23 (86) Total 651 360 Accounting Policies Staff costs are included in the income statement as follows: Share-based Compensation Expenses Genmab has granted restricted stock units (RSUs) and war-rants to the Board of Directors, Executive Management and employees under various share-based compensation pro-grams. The group applies IFRS 2, according to which the fair value of the warrants and RSUs at grant date is recognized as an expense in the income statement over the vesting period. Such compensation expenses represent calculated values of warrants and RSUs granted and do not represent actual cash expenditures. A corresponding amount is recognized in shareholders’ equity as both the warrant and RSU programs are designated as equity-settled share-based payment trans-actions. Research and development expenses General and administrative expenses Government grants related to research and development expenses 572 175 (96) 324 122 (86) Total 651 360 Average number of FTE 471 313 Number of FTE at year end: 548 377 Please refer to note 5.1 for additional information regarding the remuneration of the Board of Directors and Executive Management. Government Grants The Dutch Research and Development Act “WBSO” provides compensation for a part of research and development wages and other costs through a reduction in payroll taxes. WBSO grant amounts are offset against wages and salaries and research and development costs. Financial Statements / Results for the Year 96

2.3 Staff Costs – Continued Management’s Judgments and Estimates Weighted Average 2019 2018 Share-based Compensation Expenses In accordance with IFRS 2 “Share-based Payment,” the fair value of the warrants and RSUs at grant date is recognized as an expense in the income statement over the vesting period, the period of delivery of work. Subsequently, the fair value is not remeasured. Fair value per warrant on grant date Share price Exercise price Expected dividend yield Expected stock price volatility Risk-free interest rate Expected life of warrants 425.80 1,483.58 1,483.58 0% 34.2% (0.56%) 5 years 386.61 1,034.66 1,034.66 0% 41.7% (0.01%) 5 years The fair value of each warrant granted during the year is calcu-lated using the Black-Scholes pricing model. This pricing model requires the input of subjective assumptions such as: Based on a weighted average fair value per warrant of DKK 425.80 (2018: DKK 386.61) the total fair value of warrants granted amounted to DKK 131 million (2018: DKK 102 mil-lion) on the grant date. • The expected stock price volatility , which is based upon the historical volatility of Genmab’s stock price; • The risk-free interest rate , which is determined as the interest rate on Danish government bonds (bullet issues) with a maturity of five years; The fair value of each RSU granted during the year is equal to the closing market price on the date of grant of one Genmab A/S share. Based on a weighted average fair value per RSU of DKK 1,511.70 (2018: DKK 1,033.95) the total fair value of RSUs granted amounted to DKK 176 million (2018: DKK 106 million) on the grant date. • The expected life of warrants , which is based on vesting terms, expected rate of exercise and life terms in the current warrant program. These assumptions can vary over time and can change the fair value of future warrants granted. Valuation Assumptions for Warrants Granted in 2019 and 2018 The fair value of each warrant granted during the year is calculated using the Black-Scholes pricing model with the following assumptions: Financial Statements / Results for the Year 97

2.4 Corporate and Deferred Tax 2.4 Corporate and Deferred Tax Corporate tax consists of current tax and the adjustment of deferred taxes during the year. The corporate tax expense for 2019 was DKK 693 million compared to DKK 140 million in 2018. The corporate tax expense in 2019 was due to current and deferred tax expense of DKK 722 million partially offset by the reversal of valuation allowances on deferred tax as-sets related to future taxable income, resulting in a discrete tax benefit of DKK 29 million. The corporate tax expense in 2018 was due to current and deferred tax expense of DKK 407 million partially offset by the reversal of valuation allowances on deferred tax assets related to future taxable income, resulting in a discrete tax benefit of DKK 268 million. In 2019, a current tax benefit of DKK 24 million was recorded directly in shareholders’ equity, which was related to excess tax benefits for share-based instruments. In 2018, a current tax benefit of DKK 24 million and a deferred tax benefit of DKK 66 million recorded directly in shareholders’ equity, which was related to excess tax benefits for share-based instruments. Taxation — Income Statement & Shareholders’ Equity (DKK million) 2019 2018 Current tax on result Adjustment to deferred tax Adjustment to valuation allowance 444 294 (45) 161 458 (479) Total tax for the period in the income statement 693 140 A reconciliation of Genmab’s effective tax rate relative to the Danish statutory tax rate is as follows: (DKK million) 2019 2018 Net result before tax 2,859 1,612 Computed 22% (2018: 22%) 629 355 Tax effect of: Recognition of previously unrecognized tax losses and deductible temporary differences Non-deductible expenses/non-taxable income and other permanent differences, net All other (19) 75 8 (267) 53 (1) Total tax effect 64 (215) Total tax for the period in the income statement 693 140 Total tax for the period in shareholders’ equity (24) (89) Financial Statements / Results for the Year 98

2.4 Corporate and Deferred Tax – Continued Accounting Policies Taxation – Balance Sheet Significant components of the deferred tax asset are as follows: Corporate Tax Corporate tax, which consists of current tax and the adjust-ment of deferred taxes for the year, is recognized in the income statement, except to the extent that the tax is attrib-utable to items which directly relate to shareholders’ equity or other comprehensive income. (DKK million) 2019 2018 Tax deductible losses Share-Based Instruments Capitalized R&D Costs Other temporary differences 359 130 – 1 653 119 4 8 Current tax assets and liabilities for current and prior periods are measured at the amounts expected to be recovered from or paid to the tax authorities. 490 (351) 784 (398) Valuation allowance Total deferred tax assets 139 386 Deferred Tax Deferred tax is accounted for under the liability method which requires recognition of deferred tax on all temporary differences between the carrying amount of assets and liabilities and the tax base of such assets and liabilities. This includes the tax value of tax losses carried forward. Genmab records a valuation allowance to reduce deferred tax assets to reflect the net amount that is more likely than not to be realized. Realization of our deferred tax assets is dependent upon the generation of future taxable income, the amount and timing of which are uncertain. The valua-tion allowance requires an assessment of both positive and negative evidence when determining whether it is more likely than not that deferred tax assets are recoverable; such assessment is required on a jurisdiction by jurisdiction basis. Based upon the weight of available evidence at December 31, 2019, Genmab determined that it was more likely than not that a portion of our deferred tax assets would be real-izable and consequently released a portion of the valuation allowance against net deferred tax assets and during the fourth quarter of 2019 recorded a discrete tax benefit of DKK 29 million (2018: DKK 268 million). The decision to reverse a portion of the valuation allowance was made after manage-ment considered all available evidence, both positive and negative, including but not limited to our historical operating results, income or loss in recent periods, cumulative income in recent years, forecasted earnings, future taxable income, and significant risk and uncertainty related to forecasts. The release of the valuation allowance resulted in the recognition of certain deferred tax assets and a decrease to corporate tax expense. Deferred tax is calculated in accordance with the tax regulations in the individual countries and the tax rates expected to be in force at the time the deferred tax is utilized. Changes in deferred tax as a result of changes in tax rates are recognized in the income statement. As of December 31, 2019, we had gross tax loss carry-for-wards of DKK 1.6 billion for income tax purposes, as com-pared to DKK 2.6 billion in 2018. The reduction was driven primarily by the utilization of all remaining tax loss carry-forwards available for our parent entity, Genmab A/S. The DKK 1.6 billion in gross tax loss carry-forwards as of Decem-ber 31, 2019 can be carried forward through various periods through 2038. Deferred tax assets resulting from temporary differences, includ-ing the tax value of losses to be carried forward, are recognized only to the extent that it is probable that future taxable profit will be available against which the differences can be utilized. Financial Statements / Results for the Year 99

2.4 Corporate and Deferred Tax – Continued 2.5 Result Per Share Management’s Judgments and Estimates (DKK million) 2019 2018 Deferred Tax Genmab recognizes deferred tax assets, including the tax base of tax loss carry-forwards, if management assesses that these tax assets can be offset against positive taxable income within a foreseeable future. This judgment is made on an ongoing basis and is based on numerous factors, including actual results, budgets, and business plans for the coming years. Net result 2,166 1,472 (Shares) 2019 2018 Average number of shares outstanding Average number of treasury shares 63,126,771 (163,958) 61,383,972 (116,466) Average number of shares excl. treasury shares Average number of share-based instruments, dilution 62,962,813 674,030 61,267,506 777,491 Realization of deferred tax assets is dependent upon a num-ber of factors, including future taxable earnings, the timing and amount of which is highly uncertain. A significant portion of Genmab’s future taxable income will be driven by future events that are highly susceptible to factors outside the con-trol of the group including commercial growth of DARZALEX, specific clinical outcomes, regulatory approval, advancement of our product pipeline, and others. In 2018, we fully released the remaining valuation allowance on deferred tax assets for our parent entity, Genmab A/S. Genmab intends to contin-ue maintaining a valuation allowance against a significant portion of its deferred tax assets related to its subsidiaries until there is sufficient evidence to support the reversal of all or some additional portion of these allowances. The Compa-ny may release an additional part of its valuation allowance against its deferred tax assets related to its subsidiaries. This release would result in the recognition of certain deferred tax assets and a decrease to income tax expense for the period such release is recorded. Average number of shares, fully diluted 63,636,843 62,044,997 Basic net result per share Diluted net result per share 34.40 34.03 24.03 23.73 In the calculation of the diluted net result per share for 2019, 299,573 warrants (of which 744 were vested) have been excluded as these share-based instruments are out of the money, compared to 177,369 warrants (of which 64,703 were vested) for 2018. Diluted Net Result per Share Diluted net result per share is calculated as the net result for the year divided by the weighted average number of out-standing ordinary shares, excluding treasury shares adjusted for the dilutive effect of share equivalents. Accounting Policies Basic Net Result per Share Basic net result per share is calculated as the net result for the year divided by the weighted average number of out-standing ordinary shares, excluding treasury shares. Financial Statements / Results for the Year 100

3.1 Intangible Assets SOepcetriaotnin3g 3.1 Intangible Assets Assets and Liabilities (DKK million) Licenses, Rights, and Patents Total Intangible Assets 2019 Cost per January 1 Additions for the year Disposals for the year Exchange rate adjustment 798 99 – – 798 99 – – Cost at December 31 897 897 Accumulated amortization and impairment per January 1 Amortization for the year Disposals for the year Exchange rate adjustment (328) (99) – – (328) (99) – – This section covers the operating as-sets and related liabilities that form the basis for the Genmab group’s activities. Deferred tax assets and liabilities are in-cluded in note 2.4. Assets related to the group’s financing activities are shown in section 4. Accumulated amortization and impairment per December 31 (427) (427) Carrying amount at December 31 470 470 2018 Cost per January 1 Additions for the year Disposals for the year Exchange rate adjustment 392 406 – – 392 406 – – Cost at December 31 798 798 Accumulated amortization and impairment per January 1 Amortization for the year Disposals for the year Exchange rate adjustment (268) (60) – – (268) (60) – – Accumulated amortization and impairment per December 31 (328) (328) Carrying amount at December 31 470 470 Depreciation, amortization, and impairments are included in the income statement as follows: (DKK million) 2019 2018 Research and development expenses General and administrative expenses 99 – 60 – Total 99 60 Financial Statements / Operating Assets and Liabilities 101

3.1 Intangible Assets – Continued There were no impairment losses recognized in 2019 or 2018. In July 2018, Genmab entered into a research collaboration and exclusive license agreement with Immatics Biotechnol-ogies GmbH (Immatics) to discover and develop next-gener-ation bispecific immunotherapies to target multiple cancer indications. Genmab received an exclusive license to three proprietary targets from Immatics, with an option to license up to two additional targets at predetermined economics. Under the terms of the agreement, Genmab paid Immatics an upfront fee of USD 54 million and Immatics is eligible to receive up to USD 550 million in development, regulatory and commercial milestone payments for each product, as well as tiered royalties on net sales. The carrying amount of the intangible asset related to the Immatics agreements was DKK 274 million as of December 31, 2019 and DKK 323 mil-lion as of December 31, 2018. The intangible asset is being amortized on a straight line basis through July 2025. as a liability. Milestone payments are accounted for as an increase in the cost to acquire licenses, rights, and patents. Genmab acquires licenses and rights primarily to get access to targets and technologies identified by third parties. In December 2019, Genmab entered into a research collabo-ration and license agreement with CureVac AG. The strategic partnership will focus on the research and development of differentiated mRNA-based antibody products by combining CureVac’s mRNA technology and know-how with Genmab’s proprietary antibody technologies and expertise. Genmab will provide CureVac with a USD 10 million upfront payment and a EUR 20 million equity investment (Refer to Note 3.4 for details on the equity investment). The companies will collaborate on research to identify an initial product candi-date and CureVac will contribute a portion of the overall costs for the development of this product candidate, up to the time of an Investigational New Drug Application. Genmab would thereafter be fully responsible for the development and commercialization of the potential product, in exchange for undisclosed milestones and tiered royalties to CureVac. The agreement also includes three additional options for Genmab to obtain commercial licenses to CureVac’s mRNA technology at pre-defined terms, exercisable within a five-year period. If Genmab exercises any of these options, it would fund all research and would develop and commercialize any resulting product candidates with CureVac eligible to receive between USD 275 million and USD 368 million in development, regu-latory and commercial milestone payments for each product, dependent on the specific product concept. In addition, CureVac is eligible to receive tiered royalties in the range from mid-single digits up to low double digits per product. The carrying amount of the intangible asset related to the CureVac agreement was DKK 67 million as of December 31, 2019. The intangible asset is being amortized on a straight line basis through December 2026. Depreciation Licenses, rights, and patents are amortized using the straight-line method over the estimated useful life of five to seven years. Amortization, impairment losses, and gains or losses on the disposal of intangible assets are recognized in the income state-ment as research and development costs, general and adminis-trative expenses or discontinued operations, as appropriate. Impairment If circumstances or changes in Genmab’s operations indicate that the carrying amount of non-current assets in a cash-gen-erating unit may not be recoverable, management reviews the asset for impairment. The group has previously acquired licenses and rights to technology at a total cost of DKK 152 million, which have been fully amortized during the period from 2000 to 2005. The licenses and rights are still in use by the group and con-tribute to our research and development activities. Management’s Judgments and Estimates Research and Development Internally Generated Intangible Assets According to the IAS 38, “ tangible Assets,” intangible In Accounting Policies assets arising from development projects should be recog-nized in the balance sheet. The criteria that must be met for capitalization are that: Research and Development The group currently has no internally generated intangible assets from development, as the criteria for recognition of an asset are not met as described below. • the development project is clearly defined and identifiable and the attributable costs can be measured reliably during the development period; Licenses and Rights Licenses, rights, and patents are initially measured at cost and include the net present value of any future payments. The net present value of any future payments is recognized Financial Statements / Operating Assets and Liabilities 102

3.1 Intangible Assets – Continued • the technological feasibility, adequate resources to com-plete and a market for the product or an internal use of the product can be documented; and • management has the intent to produce and market the product or to use it internally. Antibody Clinical Trial Material Purchased for Use in Clinical Trials According to our accounting policies, antibody clinical trial ma-terial (antibodies) for use in clinical trials that are purchased from third parties will only be recognized in the balance sheet at cost and expensed in the income statement when con-sumed, if all criteria for recognition as an asset are fulfilled. Such an intangible asset should be recognized if sufficient certainty can be documented that the future income from the development project will exceed the aggregate cost of produc-tion, development, and sale and administration of the product. During both 2019 and 2018, no antibodies purchased from third parties for use in clinical trials have been capitalized, as these antibodies do not qualify for being capitalized as A development project involves a single product candidate undergoing a high number of tests to illustrate its safety profile and its effect on human beings prior to obtaining the necessary final approval of the product from the appropriate authorities. The future economic benefits associated with the individual development projects are dependent on obtaining such approval. Considering the significant risk and duration of the development period related to the development of biological products, management has concluded that the future economic benefits associated with the individual proj-ects cannot be estimated with sufficient certainty until the project has been finalized and the necessary final regulatory approval of the product has been obtained. Accordingly, the group has not recognized such assets at this time and therefore all research and development costs are recognized in the income statement when incurred. Total research and development costs amounted to DKK 2,386 million in 2019, compared to DKK 1,431 million in 2018. inventory under either the “ amework” to IAS/IFRS or IAS 2, Fr “ ventories.” In Management has concluded that the purchase of antibodies from third parties cannot be capitalized as the technical feasibil-ity is not proven and no alternative use exists. Expenses in con-nection with purchase of antibodies are expensed as incurred. Estimation of Useful Life Genmab has licenses, rights, and patents that are amortized over an estimated useful life of the intangible asset. As of December 31, 2019, the carrying amount of the intangible as-sets was DKK 470 million (2018 – DKK 470 million). Genmab estimates the useful life of the intangible assets to be at least seven years based on the expected obsolescence of such as-sets. However, the actual useful life may be shorter or longer than seven years, depending on the development risk, the probability of success related to the development of a clinical drug as well as potential launch of competing products. Financial Statements / Operating Assets and Liabilities 103

3.2 Property, Plant and Equipment 3.2 Property, Plant and Equipment Leasehold Improvements Equipment, Furniture and Fixtures Assets under Construction Total Property, Plant and Equipment (DKK million) Capital expenditures in 2019 and 2018 were primarily related to the expansion of our facilities in the Netherlands and the United States to support the growth in our product pipeline. 2019 Cost at January 1 Additions for the year Transfers between the classes Disposals for the year Exchange rate adjustment 95 3 – – – 217 64 – (2) – 1 48 – – – 313 115 – (2) – Accounting Policies Property, plant and equipment is mainly comprised of lease-hold improvements, assets under construction, and equip-ment, furniture and fixtures, which are measured at cost less accumulated depreciation, and any impairment losses. Cost at December 31 98 279 49 426 Accumulated depreciation and impairment at January 1 Depreciation for the year Disposals for the year Exchange rate adjustment Accumulated depreciation on disposals (8) (6) – – – (143) (34) – – 2 – – – – – (151) (40) – – 2 The cost is comprised of the acquisition price and direct costs related to the acquisition until the asset is ready for use. The present value of estimated liabilities related to the restoration of our offices in connection with the termination of the lease is added to the cost if the liabilities are provided for. Costs include direct costs, salary related expenses, and costs to subcontractors. – Accumulated depreciation and impairment at December 31 (14) (175) (189) Carrying amount at December 31 84 104 49 237 2018 Cost at January 1 Additions for the year Transfers between the classes Disposals for the year Exchange rate adjustment 11 7 83 (6) – 170 41 12 (7) 1 68 28 (95) – – 249 76 – (13) 1 Depreciation Depreciation, which is stated at cost net of any residual value, is calculated on a straight-line basis over the expected useful lives of the assets, which are as follows: Cost at December 31 95 217 1 313 Accumulated depreciation and impairment at January 1 Depreciation for the year Disposals for the year Exchange rate adjustment (6) (8) 6 – (129) (20) 6 – – – – – (135) (28) 12 – Equipment, Furniture and Fixtures 3-5 years 3 years Computer Equipment 5 years or the lease term, if shorter Leasehold Improvements Accumulated depreciation and impairment at December 31 (8) (143) – (151) Carrying amount at December 31 87 74 1 162 The useful lives and residual values are reviewed and adjust-ed if appropriate on a yearly basis. Assets under construction are not depreciated. (DKK million) 2019 2018 Depreciation, amortization, and impairments are included in the income statement as follows: Research and development expenses General and administrative expenses 37 3 26 2 Total 40 28 Financial Statements / Operating Assets and Liabilities 104

3.3 Leases Impairment If circumstances or changes in Genmab’s operations indicate that the carrying amount of non-current assets in a cash-gen-erating unit may not be recoverable, management reviews the asset for impairment. Amounts recognized in the balance sheet The balance sheet shows the following amounts relating to leases: Amounts recognized in the statement of comprehensive income The statement of comprehensive income shows the following amounts relating to leases: December 31, 2019 December 31, 2018 December 31, 2019 December 31, 2018 (DKK million) (DKK million) The basis for the review is the recoverable amount of the assets, determined as the greater of the fair value less cost to sell or its value in use. Value in use is calculated as the net present value of future cash inflow generated from the asset. Right-of-use assets Properties Equipment Depreciation charge of right-of-use assets Properties Equipment 173 4 – – 27 1 – – Total right-of-use assets 177 – Total depreciation charge of right-of-use assets Lease liabilities Current Non-current If the carrying amount of an asset is greater than the recov-erable amount, the asset is written down to the recoverable amount. An impairment loss is recognized in the income statement when the impairment is identified. 28 – 26 155 – – Interest expense Expense relating to short-term leases 7 6 – – Total lease liabilities 181 – There were no additions to the right-of-use assets in 2019. Interest expense is included in net financial items and ex-penses relating to short-term leases are included in operating expenses in the statement of comprehensive income. 3.3 Leases The total cash outflow for leases in 2019 was DKK 38 million. See the table below for activities for lease liabilities in 2019: The group has entered into lease agreements with respect to office space and office equipment. December 31, 2018 Cash flows, net Other changes* December 31, 2019 (DKK million) Lease liabilities, due after 1 year Lease liabilities, due within 1 year 181 24 (38) – 12 2 155 26 The leases are non-cancelable for various periods up to 2032. 181 Total lease liabilities 205 (38) 14 * Other changes include non-cash movements, including accrued interest expense which are presented as operating cash flows in the statement of cash flows when paid. Financial Statements / Operating Assets and Liabilities 105

3.3 Leases – Continued Future minimum payments under our leases as of December 31, 2019 and December 31, 2018, are as follows: The comparative information has not been restated and continues to be reported under the accounting standards in effect for those periods. certain that we will exercise that option. In determining the lease term, management considers all facts and circumstanc-es that create an economic incentive to exercise an extension option, or not exercise a termination option. Extension op-tions (or periods after termination options) are only included in the lease term if the lease is reasonably certain to be extended (or not terminated). (DKK million) 2019 2018 Accounting Policies All leases are recognized in the balance sheet as a right-of-Payment due Less than 1 year 1 to 3 years More than 3 years, but less than 5 years More than 5 years use (“ROU”) asset with a corresponding lease liability, except for short term assets in which the lease term is 12 months or less, or low value assets. ROU assets represent our right to use an underlying asset for the lease term and lease liabili-ties represent our obligation to make lease payments arising from the lease. The ROU asset is depreciated over the shorter of the asset’s useful life and the lease term on a straight-line basis over the lease term. In the income statement, lease costs are replaced by depreciation of the ROU asset recognized over the lease term in operating expenses, and interest expenses related to the lease liability are classified in financial items. 32 64 31 65 ROU assets are measured at cost and include the amount of the initial measurement of lease liability, any lease payments made at or before the commencement date less any lease incentives received, any initial direct costs, and restoration costs. 27 93 45 106 Total 216 247 During the second quarter of 2019, Genmab A/S’s subsid-iary Genmab US, Inc., entered into a lease agreement with respect to office and laboratory space with a commencement date in March 2020 and is non-cancellable until August 2031. The total future minimum payments over the term of the lease are approximately DKK 215 million and estimated capital expenditures to fit out the space are approximately DKK 176 million of which DKK 48 million have been incurred and capitalized as of December 31, 2019. Payments associated with short-term leases and leases of low-value assets are recognized on a straight-line basis as an expense in the income statement. Short-term leases are leases with a lease term of 12 months or less and low-value assets comprise IT equipment and small items of office furniture. Genmab determines if an arrangement is a lease at inception. Genmab leases various properties and IT equipment. Rental contracts are typically made for fixed periods. Lease terms are negotiated on an individual basis and contain a wide range of different terms and conditions. 3.4 Other Investments During the third quarter of 2019, Genmab A/S’s subsidiary Genmab B.V., entered into a lease agreement with respect to office and laboratory space with a commencement date in February 2022 and is noncancelable until January 2032. The total future minimum payments over the term of the lease are approximately DKK 90 million and estimated capital expendi-tures to fit out the space are approximately DKK 70 million. Assets and liabilities arising from a lease are initially mea-sured on a present value basis. Lease liabilities include the net present value of fixed payments, less any lease incen-tives. As our leases do not provide an implicit rate, we use our incremental borrowing rate based on the information available at commencement date in determining the present value of lease payments. Our lease terms may include op-tions to extend or terminate the lease when it is reasonably The Group’s other investments consist of a DKK 149 million (EUR 20 million) investment in CureVac AG, the developer of mRNA technology, which was entered into on December 19, 2019. This investment is also a strategic partnership that will focus on the research and development of differentiated mRNA-based antibody products by combining CureVac’s mRNA technology and know-how with Genmab’s proprietary Please refer to note 1.2 for disclosure of the impact of adop-tion of IFRS 16 on our consolidated financial statements. Financial Statements / Operating Assets and Liabilities 106

3.5 Receivables 3.6 antibody technologies and expertise. The investment in CureVac AG is recorded at fair value through profit and loss. This investment represents 2.2% ownership of CureVac AG and is recorded at a fair value of DKK 149 million as of December 31, 2019. During 2019 and 2018, there were no losses related to receivables and the credit risk on receivables is considered to be limited. The provision for expected credit losses was not significant given that there have been no credit losses over the last three years and the high-quality nature (top tier life science companies) of Genmab’s customers are not likely to result in future default risk. Provisions (DKK million) 2019 2018 The payment related to this investment has not been made as of December 31, 2019 and is recorded within other payables. Please refer to note 3.7 for additional information regarding other payables. Provisions per January 1 Additions during the year Used during the year Released during the year 1 1 – – 1 – – – The receivables are mainly comprised of royalties and mile-stones from our collaboration agreements and non-interest bearing receivables which are due less than one year from the balance sheet date. Total at December 31 2 1 Non-current provisions Current provisions 2 – 1 – Accounting Policies Other investments are measured on initial recognition at fair value, and subsequently at fair value. Changes in fair value are recognized in the income statement under financial items. Please refer to note 4.2 for additional information about interest receivables and related credit risk. Total at December 31 2 1 Provisions include contractual restoration obligations related to our lease of offices. In determining the fair value of the restoration obligation, assumptions and estimates are made in relation to discounting, the expected cost to restore the offices and the expected timing of those costs. Accounting Policies Receivables are designated as financial assets measured 3.5 at amortized cost and are initially measured at fair value or transaction price and subsequently measured in the balance sheet at amortized cost, which generally corresponds to nom-inal value less expected credit loss provision. Receivables The majority of non-current provisions are expected to be settled in 2022. (DKK million) 2019 2018 Genmab utilizes a simplified approach to measuring expect-ed credit losses and uses a lifetime expected loss allowance for all receivables. To measure the expected credit losses, receivables have been grouped based on credit risk charac-teristics and the days past due. Receivables related to collaboration agreements Interest receivables Other receivables Prepayments Accounting Policies 2,849 34 56 62 1,266 18 34 19 Provisions are recognized when the group has an existing legal or constructive obligation as a result of events occur-ring prior to or on the balance sheet date, and it is probable that the utilization of economic resources will be required to settle the obligation. Provisions are measured at manage-ment’s best estimate of the expenses required to settle the obligation. Total 3,001 1,337 Prepayments include expenditures related to a future finan-cial year. Prepayments are measured at nominal value. Non-current receivables Current receivables 11 2,990 10 1,327 Total 3,001 1,337 Financial Statements / Operating Assets and Liabilities 107

3.7 Other Payables A provision for onerous contracts is recognized when the expected benefits to be derived by the group from a contract are lower than the unavoidable cost of meeting its obligations under the contract. The provision is measured at the present value of the lower of the expected cost of terminating the con-tract and the expected net cost of continuing with the contract. Accounting Policies Accounts Payable Accounts payable are measured in the balance sheet at amortized cost. Other payables are initially measured at fair value and subse-quently measured in the balance sheet at amortized cost. The current other payables are comprised of liabilities that are due less than one year from the balance sheet date and are in general not interest bearing and settled on an ongoing basis during the financial year. Other Liabilities Other liabilities primarily includes accrued expenses related to our research and development project costs. When the group has a legal obligation to restore our office lease in connection with the termination, a provision is recognized corresponding to the present value of expected future costs. Non-current payables are measured at the present value of the expenditures expected to be required to settle the obliga-tion using a pre-tax rate that reflects current market assess-ments of the time value of money and the risks specific to the obligation. The increase in the liability due to passage of time is recognized as interest expense. The present value of a provision is calculated using a pre-tax rate that reflects current market assessments of the time value of money and the risks specific to the obligation. The increase in the provision due to passage of time is recog-nized as an interest expense. Staff Costs Liabilities Wages and salaries, social security contributions, paid leave and bonuses, and other employee benefits are recognized in the financial year in which the employee performs the associated work. 3.7 Other Payables Termination benefits are recognized as an expense, when the Genmab group is committed demonstrably, without realistic possibility of withdrawal, to a formal detailed plan to termi-nate employment. (DKK million) 2019 2018 Liabilities related to collaboration agreements Staff cost liabilities Other liabilities Accounts payable 8 48 715 69 6 30 213 69 The group’s pension plans are classified as defined contri-bution plans, and, accordingly, no pension obligations are recognized in the balance sheet. Costs relating to defined contribution plans are included in the income statement in the period in which they are accrued and outstanding contri-butions are included in other payables. Total at December 31 840 318 Non-current other payables Current other payables 1 839 2 316 Total at December 31 840 318 Financial Statements / Operating Assets and Liabilities 108

4.1 Capital Management SCaepctitioanl S4tructure, 4.1 Capital Management Financial Risk and Related Items Genmab’s goal is to maintain a strong capital base so as to maintain investor, creditor and market confidence, and a continuous advancement of Genmab’s product pipeline and business in general. and licensing arrangements, our capital expenditures, market developments, and any future acquisitions. Accordingly, we may require additional funds and may attempt to raise addi-tional funds through equity or debt financings, collaborative agreements with partners, or from other sources. Genmab is primarily financed through partnership collabora-tion income and had, as of December 31, 2019, a cash po-sition of DKK 10,971 million compared to DKK 6,106 million as of December 31, 2018. The cash position supports the advancement of our product pipeline and operations. The Board of Directors monitors the share and capital struc-ture to ensure that Genmab’s capital resources support the strategic goals. There was no change in the group’s approach to capital management procedures in 2019. This section includes disclosures related to how Genmab manages its capital structure, cash position and related risks and items. Genmab is primarily financed through partnership collaborations. The adequacy of our available funds will depend on many factors, including continued growth of DARZALEX sales, prog-ress in our research and development programs, the mag-nitude of those programs, our commitments to existing and new clinical collaborators, our ability to establish commercial Neither Genmab A/S nor any of its subsidiaries are subject to externally imposed capital requirements. Financial Statements / Capital Structure, Financial Risk and Related items 109

4.2 Financial Risk 4.2 Financial Risk The financial risks of the Genmab group are managed centrally. percent of the total portfolio required to have a maturity of less than one year. The changes were made as a result of the higher value of our marketable securities portfolio and reduced need for short duration securities. policy is to ensure only securities from investment grade issuers are eligible for our portfolios. No issuer of marketable securities can be accepted if it is not assumed that the credit quality of the issuer would be at least equal to the rating shown below: The overall risk management guidelines have been approved by the Board of Directors and includes the group’s invest-ment policy related to our marketable securities. The group’s risk management guidelines are established to identify and analyze the risks faced by the Genmab group, to set the ap-propriate risk limits and controls and to monitor the risks and adherence to limits. It is Genmab’s policy not to actively specu-late in financial risks. The group’s financial risk management is directed solely against monitoring and reducing financial risks which are directly related to the group’s operations. In addition to the capital management and financing risk men-tioned in note 4.1, the group has identified the following key financial risk areas, which are mainly related to our marketable securities portfolio: Category S&P Moody’s Fitch Short-term Long-term A-1 A-P-1 A3 F-1 A-• • • credit risk; foreign currency risk; and interest rate risk Our current portfolio is spread over a number of different securities and is conservative with a focus on liquidity and security. As of December 31, 2019, 91% of our marketable securities had a triple A-rating from Moody’s, S&P, or Fitch compared to 90% at December 31, 2018. The total value of marketable securities including interest receivables amount-ed to DKK 7,453 million at the end of 2019 compared to DKK 5,591 million at the end of 2018. The primary objective of Genmab’s investment activities is to preserve capital and ensure liquidity with a secondary objective of maximizing the income derived from security in-vestments without significantly increasing risk. Therefore, our investment policy includes among other items, guidelines and ranges for which investments (all of which are shorter-term in nature) are considered to be eligible investments for Genmab and which investment parameters are to be applied, including maturity limitations and credit ratings. In addition, the policy includes specific diversification criteria and investment limits to minimize the risk of loss resulting from over concentration of assets in a specific class, issuer, currency, country, or eco-nomic sector. All our marketable securities are traded in established markets. Given the current market conditions, all future cash inflows including re-investments of proceeds from the disposal of marketable securities are invested in highly liquid and con-servative investments. Please refer to note 4.4 for additional information regarding marketable securities. Bank Deposits To reduce the credit risk on our bank deposits, Genmab policy is only to invests its cash deposits with highly rated financial institutions. Currently, these financial institutions have a short-term Fitch and S&P rating of at least F-1 and A-1, respectively. In addition, Genmab maintains bank deposits at a level necessary to support the short-term funding require-ments of the Genmab group. The total value of bank deposits including short-term marketable securities amounted to DKK 3,552 million as of December 31, 2019 compared to DKK 533 million at the end of 2018. The increase was due to higher short-term marketable securities classified as cash and cash equivalents driven by timing and working capital needs as of December 31, 2019. Credit Risk Genmab is exposed to credit risk and losses on our market-able securities, and bank deposits. The maximum credit exposure related to Genmab’s cash position was DKK 10,971 million as of December 31, 2019 compared to DKK 6,106 million as of December 31, 2018. The maximum credit exposure to Genmab’s receivables was DKK 3,001 million as of December 31, 2019 compared to DKK 1,337 million as of December 31, 2018. Currently, our marketable securities are administrated by two external investment managers. The guidelines and investment managers are reviewed regularly to reflect changes in market conditions, the group’s activities and financial position. In 2016, the investment policy was amended to increase the investment limits for individual securities and reduce the Marketable Securities To manage and reduce credit risks on our securities, Genmab’s Financial Statements / Capital Structure, Financial Risk and Related Items 110

4.2 Financial Risk – Continued Based on the amount of assets and liabilities denominated in EUR, USD and GBP as of December 31, 2019 and 2018, a 1% increase/decrease in the EUR to DKK exchange rate and a 10% increase/decrease in both USD to DKK exchange rate and GBP to DKK exchange rate will impact our net result before tax by approximately: Receivables The credit risk related to our receivables is not significant based on the high quality nature of Genmab’s customers. As disclosed in note 2.1, Janssen is Genmab’s primary customer in which receivables are established for royalties and mile-stones achieved. Foreign Currency Risk Genmab’s presentation currency is the DKK; however, Genmab’s revenues and expenses are in a number of differ-ent currencies. Consequently, there is a substantial risk of exchange rate fluctuations having an impact on Genmab’s cash flows, profit (loss) and/or financial position in DKK. Impact of Change in Exchange Rate** Percentage Change in Exchange Rate* (DKK million) 2019 EUR USD GBP 1% 10% 10% 10 1,053 – The majority of Genmab’s revenue is in USD. Exchange rate changes to the USD will result in changes to the trans-lated value of future net result before tax and cash flows. Genmab’s revenue in USD was 97% of total revenue in 2019 as compared to 96% in 2018. 2018 EUR USD GBP 1% 10% 10% 9 362 5 The foreign subsidiaries are not significantly affected by currency risks as both revenues and expenses are primarily settled in the foreign subsidiaries’ functional currencies. * The analysis assumes that all other variables, in particular interest rates, remain constant. ** The movements in the income statement and equity arise from monetary items (cash, marketable securities, receivables and liabilities) where the func-tional currency of the entity differs from the currency that the monetary items are denominated in. Assets and Liabilities in Foreign Currency The most significant cash flows of the group are DKK, EUR, USD and GBP and Genmab hedges its currency exposure by maintaining cash positions in these currencies. Our total marketable securities were invested in EUR (12%), DKK (23%), USD (64%) and GBP (1%) denominated securities as of December 31, 2019, compared to 16%, 30%, 53%, and 1%, as of December 31, 2018. Financial Statements / Capital Structure, Financial Risk and Related Items 111

4.2 Financial Risk – Continued Accordingly, significant changes in exchange rates could cause our net result to fluctuate significantly as gains and losses are recognized in the income statement. Our EUR exposure is mainly related to our marketable securities, contracts and other costs denominated in EUR. Since the introduction of EUR in 1999, Denmark has committed to maintaining a central rate of 7.46 DKK to the EUR. This rate may fluctuate within a +/-2.25% band. Should Denmark’s policy towards the EUR change, the DKK values of our EUR denominated assets and costs could be materially different compared to what is calculated and reported under the existing Danish policy towards the DKK/EUR. Marketable Securities The securities in which the group has invested bear interest rate risk, as a change in market derived interest rates may cause fluctuations in the fair value of the investments. In ac-cordance with the objective of the investment activities, the portfolio of securities is monitored on a total return basis. Maturity Profile Marketable Securities (DKK million) 2019 2020 2021 2022 2023 2024+ 2,880 To control and minimize the interest rate risk, the group maintains an investment portfolio in a variety of securities with a relatively short effective duration with both fixed and variable interest rates. 138 As of December 31, 2019, the portfolio has an average effective duration of approximately 1.1 years (2018: 1.4 years) and no securities have an effective duration of more than 9 years (2018: 8 years), which means that a change in the interest rates of one percentage point will cause the fair value of the securities to change by approximately 1.1% (2018: 1.4%). Due to the short-term nature of the current investments and to the extent that we are able to hold the investments to maturity, we consider our current exposure to changes in fair value due to interest rate changes to be insignificant compared to the fair value of the portfolio. 75 The USD currency exposure was mainly related to cash de-posits, marketable securities, and receivables related to our collaborations with Janssen and Novartis. Significant changes in the exchange rate of USD to DKK could cause the net result to change materially as shown in the table above. In prior years, Genmab has entered into derivative contracts to hedge a portion of the associated currency exposure of royalty pay-ments from net sales of DARZALEX by Janssen. As of Decem-ber 31, 2019, there were no derivatives outstanding. 3,891 The GBP currency exposure is mainly related to contracts and marketable securities denominated in GBP. Interest Rate Risk Genmab’s exposure to interest rate risk is primarily related to the marketable securities, as we currently do not have significant interest bearing debts. Financial Statements / Capital Structure, Financial Risk and Related Items 112 2019 2,190 743 493 102 2018 1,574 505401

4.3 Financial Assets and Liabilities 4.3 Financial Assets and Liabilities Accounting Policies Categories of Financial Assets and Liabilities Classification of Categories of Financial Assets and Liabilities Genmab classifies its financial assets held into the following measurement categories: (DKK million) Note 2019 2018 Category Financial assets at fair value through profit or loss Marketable securities Other Investments • those to be measured subsequently at fair value (either through other comprehensive income, or through profit or loss), and those to be measured at amortized cost. 4.4 3.4 7,419 149 5,573 – Financial assets measured at amortized cost Receivables ex. prepayments Cash and cash equivalents • 3.5 2,939 3,552 1,318 533 The classification depends on the business model for manag-ing the financial assets and the contractual terms of the cash flows. Financial liabilities measured at amortized cost Other payables Lease Liabilities 3.7 3.3 (840) (181) (318) – For assets measured at fair value, gains and losses will either be recorded in profit or loss or other comprehensive income. Fair Value Measurement Marketable Securities All fair market values are determined by reference to exter-nal sources using unadjusted quoted prices in established markets for our marketable securities (Level 1). Other Investments The Group’s other investments consist of a DKK 149 million investment in CureVac AG, the developer of mRNA technology, which was entered into on December 19, 2019 (Level 3). Genmab reclassifies debt investments when and only when its business model for managing those assets changes. Further details about the accounting policy for each of the categories are outlined in the respective notes. 2019 2018 (DKK million) Note Fair Value Measurement The Genmab group measures financial instruments, such as marketable securities, at fair value at each balance sheet date. Management assessed that financial assets and lia-bilities measured at amortized costs such as bank deposits, receivables and other payables approximate their carrying amounts largely due to the short-term maturities of these instruments. Level 1 Level 2 Level 3 Level 1 Level 2 Level 3 Assets Measured at Fair Value Marketable securities Other Investments 4.4 3.4 7,419 – – – – 149 5,573 – – – – – Financial Statements / Capital Structure, Financial Risk and Related Items 113

4.3 Financial Assets and Liabilities – Continued Fair value is the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value measurement is based on the presumption that the transaction to sell the asset or transfer the liability takes place either: For financial instruments that are measured in the balance sheet at fair value, IFRS 13 for financial instruments requires disclosure of fair value measurements by level of the follow-ing fair value measurement hierarchy for: • Level 1 – Quoted prices (unadjusted) in active markets for identical assets or liabilities • In the principal market for the asset or liability, or • Level 2 – Inputs other than quoted prices included within level 1 that are observable for the asset or liability, either directly (that is, as prices) or indirectly (that is, derived from prices) • In the absence of a principal market, in the most advanta-geous market for the asset or liability. The principal or the most advantageous market must be accessible by the Genmab group. • Level 3 – Inputs for the asset or liability that are not based on observable market data (that is, unobservable inputs). The fair value of an asset or a liability is measured using the assumptions that market participants would use when pric-ing the asset or liability, assuming that market participants act in their economic best interest. For assets and liabilities that are recognized in the finan-cial statements on a recurring basis, the group determines whether transfers have occurred between levels in the hierarchy by re-assessing categorization (based on the lowest level input that is significant to the fair value measurement as a whole) at the end of each reporting period. Any transfers between the different levels are carried out at the end of the reporting period. There have not been any transfers between the different levels during 2019 and 2018. The Genmab group uses valuation techniques that are appropriate in the circumstances and for which sufficient data are available to measure fair value, maximizing the use of relevant observable inputs and minimizing the use of unobservable inputs. Financial Statements / Capital Structure, Financial Risk and Related Items 114

4.4 Marketable Securities 4.4 Marketable Securities Interest Income Total interest income amounted to DKK 120 million in 2019 compared to DKK 63 million in 2018. The increase was due to the combination of higher yield and level of investment in marketable securities in 2019 as compared to 2018. (DKK million) 2019 2018 Cost at January 1 Additions for the year Disposals for the year 5,494 5,812 (3,926) 4,195 3,521 (2,222) Cost at December 31 7,380 5,494 Fair value adjustment at January 1 Fair value adjustment for the year 79 (40) (120) 199 Fair Value Adjustment The total fair value adjustment was an expense of DKK 40 million in 2019 compared to income of DKK 199 million in 2018. Fair value adjustments were primarily driven by foreign exchange movements and the timing of maturities and pur-chases of marketable securities. Fair value adjustment at December 31 39 79 Net book value at December 31 7,419 5,573 Net book value in percentage of cost 101% 101% Please refer to note 4.2 for additional information regarding the risks related to our marketable securities. Market Value 2019 Average Effective Duration Market Value 2018 Average Effective Duration Share % Share % (DKK million) Kingdom of Denmark bonds and treasury bills Danish mortgage-backed securities 462 1,227 1.84 2.33 6% 17% 508 1,177 1.94 2.58 9% 21% DKK portfolio 1,689 2.20 23% 1,685 2.39 30% EUR portfolio European government bonds and treasury bills USD portfolio US government bonds and treasury bills GBP portfolio UK government bonds and treasury bills 873 1.33 12% 875 1.38 16% 4,778 0.63 64% 2,938 0.84 53% 79 0.55 1% 75 0.55 1% Total portfolio 7,419 1.07 100% 5,573 1.39 100% Marketable securities 7,419 5,573 Financial Statements / Capital Structure, Financial Risk and Related Items 115

4.4 Marketable Securities – Continued Genmab’s portfolio is managed and evaluated on a fair value basis in accordance with its investment guidelines and the information provided internally to management. This busi-ness model does not meet the criteria for amortized cost or FVOCI and as a result marketable securities are measured at fair value through profit and loss. This classification is consistent with the prior year’s classification. Accounting Policies Marketable securities consist of investments in securities with a maturity greater than three months at the time of ac-quisition. Measurement of marketable securities depends on the business model for managing the asset and the cash flow characteristics of the asset. There are two measurement cate-gories into which the group classifies its debt instruments: Genmab invests its cash in deposits with major financial institutions, in Danish mortgage bonds, and notes issued by the Danish, European and American governments. The secu-rities can be purchased and sold using established markets. • Amortized cost: Assets that are held for collection of contractual cash flows, where those cash flows represent solely payments of principal and interest, are measured at amortized cost. Interest income from these financial assets is included in finance income using the effective interest rate method. Any gain or loss arising on derecognition is recognized directly in profit or loss and presented in other gains/(losses), together with foreign exchange gains and losses. Impairment losses are presented as a separate line item in the statement of profit or loss. Transactions are recognized at trade date. • Fair value through profit and loss (FVPL): Assets that do not meet the criteria for amortized cost or FVOCI are measured at FVPL. A gain or loss on a debt investment that is subsequently measured at FVPL is recognized in profit or loss and presented net within other gains/(losses) in the period in which it arises. Financial Statements / Capital Structure, Financial Risk and Related Items 116

4.5 Financial Income and Expenses 4.5 Financial Income and Expenses (DKK million) Accounting Policies 2019 2018 Financial income and expenses include interest as well as realized and unrealized exchange rate adjustments and real-ized and unrealized gains and losses on marketable securi-ties (designated as fair value through the income statement), and realized gains and losses and write-downs of other securities and equity interests (designated as available-for-sale financial assets). Financial income: Interest and other financial income Realized and unrealized gains on marketable securities (fair value through income statement), net Realized and unrealized gains on fair value hedges, net Realized and unrealized exchange rate gains, net 120 63 9 – 99 – 2 178 Total financial income 228 243 Interest and dividend income are shown separately from gains and losses on marketable securities and other securi-ties and equity interests. Financial expenses: Interest and other financial expenses Realized and unrealized losses on marketable securities (fair value through the income statement), net 7 – – 11 Gains or losses relating to the ineffective portion of a cash flow hedge and changes in time value are recognized im-mediately in the income statement as part of the financial income or expenses. Total financial expenses 7 11 Net financial items 221 232 Interest and other financial income on financial assets measured at amortized cost 22 8 Interest and other financial expenses on financial liabilities measured at amortized cost – – Realized and unrealized exchange rate gains, net of DKK 99 million in 2019 were driven by foreign exchange movements, which positively impacted our USD denominated portfolio and cash holdings. The USD strengthened against the DKK during 2019, resulting in realized and unrealized exchange rates gains. More specifically, the USD/DKK foreign exchange rate increased from 6.5213 at December 31, 2018 to 6.6759 at December 31, 2019. Please refer to note 4.2 for additional information on foreign currency risk. Financial Statements / Capital Structure, Financial Risk and Related Items 117

4.6 Share-Based Instruments 4.6 Share-Based Instruments Within 30 days of the vesting date, the holder of an RSU receives one share in Genmab A/S for each RSU. In juris-dictions in which Genmab as an employer is required to withhold tax and settle with the tax authority on behalf of the employee, Genmab withholds the number of RSUs that are equal to the monetary value of the employee’s tax obligation from the total number of RSUs that otherwise would have been issued to the employee upon vesting (“net settle-ment”). Genmab A/S may at its sole discretion in extraordi-nary circumstances choose to make cash settlement instead of delivering shares. Restricted Stock Unit Program Genmab A/S has established an RSU program (equity-settled share-based payment transactions) as an incentive for all the Genmab group’s employees, members of the Executive Management, and members of the Board of Directors. RSUs are granted by the Board of Directors in accordance with authorizations given to it by Genmab A/S’ shareholders and are subject to the incentive guidelines (Remuneration Principles) adopted by the general meeting. Under the terms of the RSU program, RSUs are subject to a cliff vesting period and become fully vested on the first banking day of the month following a period of three years from the date of grant. If an employee, member of Executive Management, or member of the Board of Directors ceases their employment or board membership prior to the vesting date, all RSUs that are granted, but not yet vested, shall lapse automatically. The RSU program contains anti-dilution provisions if changes occur in Genmab’s share capital prior to the vesting date and provisions to accelerate vesting of RSUs in the event of change of control as defined in the RSU program. However, if an employee, a member of the Executive Manage-ment or a member of the Board of Directors ceases employ-ment or board membership due to retirement or age limita-tion in Genmab A/S’ articles of association, death, serious sickness or serious injury then all RSUs that are granted, but not yet vested shall remain outstanding and will be settled in accordance with their terms. In addition, for an employee or a member of the Executive Management, RSUs that are granted, but not yet vested shall remain outstanding and will be settled in accordance with their terms in instances where the employment relationship is terminated by Genmab without cause. Financial Statements / Capital Structure, Financial Risk and Related Items 118

4.6 Share-Based Instruments – Continued Warrant Program Genmab A/S has established warrant programs (equity-set-tled share-based payment transactions) as an incentive for all the Genmab group’s employees, and members of the Executive Management. RSU Activity in 2019 and 2018 Number of RSUs Held by Former Members of the Board of Directors and Employees Number of RSUs Held by the Executive Management Number of RSUs Held by the Board of Directors Number of RSUs Held by Employees Total RSUs Warrants are granted by the Board of Directors in accor-dance with authorizations given to it by Genmab A/S’ shareholders. Outstanding at January 1, 2018 Granted* Settled Transferred Cancelled 24,328 5,224 (9,425) – – 83,857 18,020 (35,725) – – 55,475 79,395 – (3,358) (1,466) 4,384 – (2,300) 3,358 (2,865) 168,044 102,639 (47,450) – (4,331) Warrant grants to Executive Management are subject to the incentive guidelines (Remuneration Principles) adopted by the general meeting. Outstanding at December 31, 2018 20,127 66,152 130,046 2,577 218,902 Outstanding at January 1, 2019 Granted* Settled Transferred Cancelled 20,127 3,708 (2,631) (1,251) – 66,152 25,793 (19,080) – – 130,046 87,168 – (8,355) – 2,577 73 (478) 9,606 (5,548) 218,902 116,742 (22,189) – (5,548) Under the terms of the warrant programs, warrants are granted at an exercise price equal to the share price on the grant date. According to the warrant programs, the exercise price cannot be fixed at a lower price than the market price at the grant date. In connection with exercise, the warrants shall be settled with the delivery of shares in Genmab A/S. Outstanding at December 31, 2019 19,953 72,865 208,859 6,230 307,907 * RSUs held by the Board of Directors includes RSUs granted to employee-elected Board Members as employees of Genmab A/S or its subsidiaries. Please refer to note 5.1 for additional information regarding the number of RSUs held by the Executive Management and the Board of Directors. The warrant programs contain anti-dilution provisions if changes occur in Genmab’s share capital prior to the war-rants being exercised. The weighted average fair value of RSUs granted was DKK 1,511.70 and DKK 1,033.95 in 2019 and 2018, respectively. Warrants Granted from August 2004 until April 2012 Under the August 2004 warrant program, warrants can be exercised starting from one year after the grant date. As a general rule, the warrant holder may only exercise 25% of the warrants granted per full year of employment or affilia-tion with Genmab after the grant date. Financial Statements / Capital Structure, Financial Risk and Related Items 119

4.6 Share-Based Instruments – Continued However, the warrant holder will be entitled to continue to be able to exercise all warrants on a regular schedule in instances where the employment relationship is terminated by Genmab without cause. Warrants Granted from March 2017 In March 2017, a new warrant program was adopted by the Board of Directors. Whereas warrants granted under the April 2012 warrant program vested annually over a four year period, warrants granted under the new March 2017 warrant program are subject to a cliff vesting period and become ful-ly vested three years from the date of grant. All other terms in the warrant programs are identical. In case of a change of control event as defined in the warrant programs, the warrant holder will immediately be granted the right to exercise all of his/her warrants regard-less of the fact that such warrants would otherwise only become fully vested at a later point in time. Warrant holders who are no longer employed by or affiliated with Genmab will, however, only be entitled to exercise such percentag-es as would otherwise have vested under the terms of the warrant program. Warrants Granted from April 2012 until March 2017 Following the Annual General Meeting in April 2012, a new warrant program was adopted by the Board of Directors. Whereas warrants granted under the August 2004 warrant program will lapse on the tenth anniversary of the grant date, warrants granted under the new April 2012 warrant program will lapse at the seventh anniversary of the grant date. All other terms in the warrant programs are identical. Financial Statements / Capital Structure, Financial Risk and Related Items 120

4.6 Share-Based Instruments – Continued Warrant activity in 2019 and 2018 Number of Warrants Held by Former Members of the Executive Management, Board of Directors and Employees Number of Warrants Held by the Board of Directors Number of Warrants Held by the Executive Management Number of Warrants Held by Employees Weighted Average Exercise Price Total Warrants (DKK million) Outstanding at January 1, 2018 Granted* Exercised Expired Cancelled Transfers 92,242 3,161 (20,925) – – – 559,737 50,464 (130,000) – – – 574,295 222,882 (46,883) – (4,582) (39,624) 291,912 – (114,089) (37,875) (17,129) 39,624 1,518,186 276,507 (311,897) (37,875) (21,711) – 436.01 1,034.66 241.34 253.76 940.01 – Outstanding at December 31, 2018 74,478 480,201 706,088 162,443 1,423,210 592.14 Exercisable at year end Exercisable warrants in the money at year end 62,647 60,688 355,347 340,775 297,128 257,115 152,743 148,701 867,865 807,279 295.02 230.43 Outstanding at January 1, 2019 Granted* Exercised Expired Cancelled Transfers 74,478 3,925 (15,750) – – (319) 480,201 – (132,400) – – – 706,088 303,066 (56,237) – – (93,944) 162,443 228 (95,044) (2,000) (15,374) 94,263 1,423,210 307,219 (299,431) (2,000) (15,374) – 592.14 1,483.58 212.23 129.75 1,049.34 – Outstanding at December 31, 2019 62,334 347,801 858,973 144,516 1,413,624 862.03 Exercisable at year end Exercisable warrants in the money at year end 50,227 50,227 230,233 227,733 225,855 219,403 131,933 129,698 638,248 627,061 407.89 385.84 * Warrants held by the Board of Directors includes warrants granted to employee-elected Board Members as employees of Genmab A/S or its subsidiaries. Please refer to note 5.1 for additional information regarding the number of warrants held by the Executive Management and the Board of Directors. As of December 31, 2019, the 1,413,624 outstanding war-rants amounted to 2% of the share capital (2018: 2%). For exercised warrants in 2019 the weighted average share price at the exercise date amounted to DKK 1,267.92 (2018: DKK 1,206.11). Financial Statements / Capital Structure, Financial Risk and Related Items 121

4.6 Share-Based Instruments – Continued Weighted Average Outstanding Warrants at December 31, 2019 Weighted Average Outstanding Warrants at December 31, 2018 Number of Warrants Outstanding Weighted Average Remaining Contractual Life (in years) Number of Warrants Exercisable Number of Warrants Outstanding Weighted Average Remaining Contractual Life (in years) Number of Warrants Exercisable Exercise Price Exercise Price Grant Date Grant Date (DKK) (DKK) 31.75 40.41 45.24 46.74 55.85 66.60 67.50 68.65 79.25 80.55 98.00 129.75 147.50 174.00 199.00 210.00 220.40 225.30 225.90 231.50 234.00 337.40 466.20 623.50 636.50 815.50 939.50 962.00 1,025.00 1,032.00 1,050.00 1,136.00 1,145.00 1,210.00 1,233.00 1,402.00 1,408.00 1,424.00 1,427.00 1,432.00 October 14, 2011 June 22, 2011 April 25, 2012 June 2, 2010 April 6, 2011 December 9, 2010 October 14, 2010 April 21, 2010 October 9, 2012 December 5, 2012 January 31, 2013 October 8, 2009 April 17, 2013 June 17, 2009 June 12, 2013 February 10, 2014 October 15, 2014 June 12, 2014 December 6, 2013 October 10, 2013 April 15, 2009 December 15, 2014 March 26, 2015 June 11, 2015 October 7, 2015 March 17, 2016 December 10, 2015 June 7, 2018 December 10, 2018 December 15, 2017 September 21, 2018 October 6, 2016 December 15, 2016 April 10, 2018 June 9, 2016 March 28, 2017 June 8, 2017 February 10, 2017 March 29, 2017 October 5, 2017 7,525 85,975 1,000 85,000 8,500 37,750 3,250 5,450 5,000 111,750 1,375 5,075 7,750 25,000 1,000 3,088 33,800 7,975 175,047 7,850 6,100 90,945 11,061 6,350 24,500 14,837 80,874 14,714 210,437 133,637 33,226 19,450 86,660 14,954 14,438 8,736 5,224 1,606 8,400 17,901 2.79 2.48 0.32 1.42 2.27 1.94 1.79 1.31 0.78 0.93 1.08 0.77 1.30 0.46 1.45 2.11 2.79 2.45 1.93 1.78 0.29 2.96 3.24 3.45 3.77 4.21 3.94 6.44 6.94 5.96 6.73 4.77 4.96 6.28 4.44 5.24 5.44 5.11 5.25 5.76 7,525 85,975 1,000 85,000 8,500 37,750 3,250 5,450 5,000 111,750 1,375 5,075 7,750 25,000 1,000 3,088 33,800 7,975 175,047 7,850 6,100 90,945 6,664 3,913 16,250 6,362 57,880 – – – – 9,725 43,675 – 6,713 – – 478 – – 31.75 40.41 46.74 55.85 66.60 67.50 68.65 147.50 199.00 210.00 220.40 225.30 225.90 231.50 337.40 466.20 623.50 636.50 815.50 939.50 962.00 1,025.00 1,032.00 1,050.00 1,136.00 1,145.00 1,147.50 1,155.00 1,161.00 1,210.00 1,233.00 1,334.50 1,402.00 1,408.00 1,424.00 1,427.00 1,432.00 1,615.00 October 14, 2011 June 22, 2011 June 2, 2010 April 6, 2011 December 9, 2010 October 14, 2010 April 21, 2010 April 17, 2013 June 12, 2013 February 10, 2014 October 15, 2014 June 12, 2014 December 6, 2013 October 10, 2013 December 15, 2014 March 26, 2015 June 11, 2015 October 7, 2015 March 17, 2016 December 10, 2015 June 7, 2018 December 10, 2018 December 15, 2017 September 21, 2018 October 6, 2016 December 15, 2016 June 6, 2019 March 29, 2019 March 1, 2019 April 10, 2018 June 9, 2016 October 11, 2019 March 28, 2017 June 8, 2017 February 10, 2017 March 29, 2017 October 5, 2017 December 5, 2019 5,950 80,205 85,000 5,500 35,500 3,250 3,325 1,500 1,000 2,750 17,750 4,625 137,059 3,665 50,986 8,100 2,575 21,000 12,449 73,162 14,564 206,097 131,444 27,082 18,450 83,287 21,343 7,959 19,830 14,881 13,763 62,848 8,736 5,151 1,526 8,400 17,901 195,011 1.79 1.48 0.42 1.27 0.94 0.79 0.31 0.30 0.45 1.11 1.79 1.45 0.93 0.78 1.96 2.24 2.45 2.77 3.21 2.94 5.44 5.94 4.96 5.73 3.77 3.96 6.43 6.25 6.17 5.28 3.44 6.78 4.24 4.44 4.11 4.25 4.76 6.93 5,950 80,205 85,000 5,500 35,500 3,250 3,325 1,500 1,000 2,750 17,750 4,625 137,059 3,665 50,986 8,100 2,575 21,000 8,390 73,162 – – – – 14,089 62,190 – – – – 9,903 – – – 774 – – – 862.03 1,413,624 4.05 638,248 592.14 1,423,210 3.76 867,865 Financial Statements / Capital Structure, Financial Risk and Related Items 122

4.7 Share Capital 4.7 On July 17, 2019, the Board of Directors partly exercised the authority in accordance with the authorization described above, to increase the share capital without pre-emption rights for the existing shareholders by nominally DKK 2,850,000. Additionally, on July 17, 2019, the Board of Directors partly exercised the authority to increase the share capital without pre-emption rights for the existing sharehold-ers by nominally DKK 427,500. The remaining amount of the authorization is thus DKK 4,222,500. Moreover, by decision of the General Meeting on March 29, 2019 the Board of Directors is authorized to issue on one or more occasions additional warrants to subscribe Genmab A/S’ shares up to a nominal value of DKK 500,000 to Genmab A/S’ employees as well as employees of Genmab A/S’ directly and indirectly owned subsidiaries, excluding executive manage-ment, and to make the related capital increases in cash up to a nominal value of DKK 500,000. This authorization shall remain in force for a period ending on March 28, 2024. Share Capital Share Capital The share capital comprises the nominal amount of the parent company’s ordinary shares, each at a nominal value of DKK 1. All shares are fully paid. On December 31, 2019, the share capital of Genmab A/S comprised 65,074,502 shares of DKK 1 each with one vote. There are no restrictions related to the transferability of the shares. All shares are regarded as negotiable instruments and do not confer any special rights upon the holder, and no shareholder shall be under an obligation to allow his/her shares to be redeemed. Until March 17, 2021, the Board of Directors is authorized by one or more issues to raise loans against bonds or other financial instruments up to a maximum amount of DKK 3 billion with a right for the lender to convert his/her claim to a maximum of nominally DKK 4,000,000 equivalent to 4,000,000 new shares (convertible loans). Convertible loans may be raised in DKK or the equivalent in foreign currency (including US dollar (USD) or euro (EUR)). The Board of Directors is also authorized to effect the consequential increase of the capital. Convertible loans may be raised against payment in cash or in other ways. The subscription of shares shall be with or without pre-emption rights for the shareholders and the convertible loans shall be offered at a subscription price and conversion price that in the aggregate at least corresponds to the market price of the shares at the time of the decision of the Board of Directors. The time limit for conversion may be fixed for a longer period than five (5) years after the raising of the convertible loan. Subject to the rules in force at any time, the Board of Direc-tors may reuse or reissue lapsed non-exercised warrants, if any, provided that the reuse or reissue occurs under the same terms and within the time limitations set out in the authorization to issue warrants. As of December 31, 2019, a total of 346,337 warrants have been issued and a total of 9,988 warrants have been reissued under the March 28, 2017 authorization, and a total of 283,282 warrants have been issued and a total of 76 warrants have been reissued under the March 29, 2019 authorization. A total of 370,381 warrants remain available for issue and a total of 7,883 warrants remain available for reissue as of December 31, 2019. Until April 10, 2023, the Board of Directors is authorized to increase the nominal registered share capital on one or more occasions by up to nominally DKK 7,500,000 by subscription of new shares that shall have the same rights as the existing shares of Genmab. The capital increase can be made by cash or by non-cash payment and with or without pre-emption rights for the existing shareholders. Within the authorizations to increase the share capital by nominally DKK 7,500,000 shares, the Board of Directors may on one or more occasions and without pre-emption rights for the existing shareholders of Genmab issue up to nominally DKK 2,000,000 shares to employees of Genmab, and Genmab’s subsidiaries, by cash payment at market price or at a discount price as well as by the issue of bonus shares. No transferability restrictions or redemption obligations shall apply to the new shares, which shall be negotiable instruments in the name of the holder and registered in the name of the holder in Genmab’s Reg-ister of Shareholders. The new shares shall give the right to dividends and other rights as determined by the Board in its resolution to increase capital. By decision of the general meeting on March 17, 2016, the Board of Directors was authorized to repurchase Genmab A/S’ shares up to a nominal value of DKK 500,000 (500,000 shares). This authorization shall remain in force for a period ending on March 17, 2021. In addition, by decision of the gen-eral meeting on March 29, 2019, the Board of Directors was authorized to repurchase Genmab A/S’ shares up to a nominal value of DKK 500,000 (500,000 shares). This authorization shall remain in force for a period ending on March 28, 2024. By decision of the general meeting on April 9, 2014, the Board of Directors was authorized to issue on one or more occasions warrants to subscribe Genmab A/S’ shares up to a nominal value of DKK 500,000. This authorization shall remain in force for a period ending on April 9, 2019. Further, by decision of the general meeting on March 28, 2017, the Board of Directors was authorized to issue on one or more occasions warrants to subscribe Genmab A/S’ shares up to a nominal value of DKK 500,000. This authorization shall remain in force for a period ending on March 28, 2022. As of December 31, 2019, a total of 225,000 shares, with a nominal value of DKK 225,000, have been repurchased under the March 17, 2016 authorization. A total of 775,000 shares, Financial Statements / Capital Structure, Financial Risk and Related Items 123

4.7 Share Capital – Continued with a nominal value of DKK 775,000, remain available to repurchase as of December 31, 2019. On July 22, 2019, gross proceeds from the issuance of new shares amounted to USD 506 million (DKK 3,368 million) with a corresponding increase in share capital of 2,850,000 ordinary shares or 28,500,000 ADSs. The underwriters exer-cised in full their option to purchase an additional 427,500 ordinary shares or 4,275,000 ADSs bringing the total shares issued to 3,277,500 and total gross proceeds of the offering to USD 582 million (DKK 3,873 million), which was comple-ted on July 23, 2019. Treasury Shares Share Capital (DKK million) Propor-tion of Share Capital (%) Cost (DKK million) Number of Shares Share Premium The share premium reserve is comprised of the amount received, attributable to shareholders’ equity, in excess of the nominal amount of the shares issued at the parent com-pany’s offerings, reduced by any external expenses directly attributable to the offerings. The share premium reserve can be distributed. Shareholding at December 31, 2017 100,000 0.1 0.2 118 Purchase of treasury shares Shares used for funding RSU Program 125,000 0.1 0.2 146 (47,450) – (0.1) (56) Shareholding at December 31, 2018 During 2019, 299,431 new shares were subscribed at a price of DKK 31.75 to DKK 1,424.00 in connection with the exercise of warrants under Genmab’s warrant program. 177,550 0.2 0.3 208 Changes in Share Capital during 2013 to 2019 The share capital of DKK 65 million at December 31, 2019 is divided into 65,074,502 shares at a nominal value of DKK 1 each. Shares used for funding RSU Program (13,629) – – (16) Shareholding at December 31, 2019 During 2018, 311,897 new shares were subscribed at a price of DKK 40.41 to DKK 1,233.00 in connection with the exercise of warrants under Genmab’s warrant program. 163,921 0.2 0.3 192 Genmab has two authorizations to repurchase shares as of December 31, 2019. The first authorization, granted on March 17, 2016, authorizes the Board of Directors to repurchase up to a total of 500,000 shares (with a nominal value of DKK 500,000) and shall lapse on March 17, 2021. The second authorization, granted on March 29, 2019, authorizes the Board of Directors to repurchase up to an additional 500,000 shares (with a nominal value of DKK 500,000) and shall lapse on March 28, 2024. The authorizations are intended to cover obligations in relation to the RSU program and reduce the dilution effect of share capital increases resulting from future exercises of warrants. Number of Shares Share Capital (DKK million) During 2017, 835,618 new shares were subscribed at a price of DKK 31. 75 to DKK 1,233.00 in connection with the exer-cise of warrants under Genmab’s warrant program. December 31, 2013 51,755,722 51.8 Shares issued for cash Exercise of warrants 4,600,000 611,697 4.6 0.6 December 31, 2014 56,967,419 57.0 During 2016, 818,793 new shares were subscribed at a price of DKK 31. 75 to DKK 636.50 in connection with the exercise of warrants under Genmab’s warrant program. Exercise of warrants 2,563,844 2.6 December 31, 2015 59,531,263 59.6 Exercise of warrants 818,793 0.8 During 2015, 2,563,844 new shares were subscribed at a price of DKK 26.75 to DKK 364.00 in connection with the exercise of warrants under Genmab’s warrant program. December 31, 2016 60,350,056 60.4 Exercise of warrants 835,618 0.8 During 2018, Genmab acquired 125,000 of its own shares, ap-proximately 0.2% of share capital, to cover its obligations under the RSU program. The total amount paid to acquire the shares, including directly attributable costs, was DKK 146 million and has been recognized as a deduction to shareholders’ equity. These shares are classified as treasury shares and are presented within retained earnings as of December 31, 2019 and 2018. The shares were acquired in accordance with the authoriza-tion granted by the Annual General Meeting in March 2016. There were no acquisitions of treasury shares in 2019. 124 December 31, 2017 61,185,674 61.2 During 2014, 611,697 new shares were subscribed at a price of DKK 26.75 to DKK 234.00 in connection with the exercise of warrants under Genmab’s warrant program. Exercise of warrants 311,897 0.3 December 31, 2018 61,497,571 61.5 Shares issued for cash Exercise of warrants 3,277,500 299,431 3.3 0.3 On January 24, 2014 Genmab completed a private placement with the issuance of 4,600,000 new shares. December 31, 2019 65,074,502 65.1 Financial Statements / Capital Structure, Financial Risk and Related Items

5.1 Remuneration of the Board of Directors and Executive Management SOethcetiron 5 Disclosures 5.1 Remuneration of the Board of Directors and Executive Management The total remuneration of the Board of Directors and Executive Management is as follows: (DKK million) 2019 2018 Wages and salaries Share-based compensation expenses Defined contribution plans 42 38 1 34 32 1 This section is comprised of various statutory disclosures or notes that are of secondary importance for the understanding of the Genmab group’s financials. Total 81 67 The remuneration packages for the Board of Directors and Executive Management are described below in further detail. The remuneration packages are denominated in DKK, EUR, or USD. The Compensation Committee performs an annual review of the remuneration packages. All incentive and vari-able remuneration shall be considered and adopted at the company’s annual general meeting. In accordance with Genmab’s accounting policies, described in note 2.3, share-based compensation is included in the income statement and reported in the remuneration tables in this note. Such share-based compensation expense rep-resents a calculated fair value of instruments granted and does not represent actual cash compensation received by the board members or executives. Please refer to note 4.6 for additional information regarding Genmab’s share-based compensation programs. Financial Statements / Other Disclosures 125

5.1 Remuneration of the Board of Directors and Executive Management – Continued Remuneration to the Board of Directors Purpose and Link to Strategy Performance Metrics Opportunity Changes Compared to 2018 Ensure Genmab can attract qualified individuals to the Board of Directors Basic board fee of DKK 400,000 – Deputy Chairman receives double and Chairman receives triple None Annual board base fee and fees for committee work Audit and Finance Committee membership basic fee of DKK 100,000 with Chairman receiving fee of DKK 150,000 plus a fee per meeting of DKK 10,000 None Compensation Committee membership basic fee of DKK 80,000 with Chairman receiving fee of DKK 120,000 plus a fee per meeting of DKK 10,000 None Nominating and Corporate Governance Committee membership basic fee of DKK 70,000 with Chairman receiving fee of DKK 100,000 plus a fee per meeting of DKK 10,000 None Scientific Committee membership basic fee of DKK 100,000 with Chairman receiving fee of DKK 130,000 plus a fee per meeting of DKK 10,000 None Share-based instru-ments constitute a common part of the remuneration paid to members of the Board of Directors in compet-ing international biotech and biopharmaceutical companies. The use of share-based instru-ments enables Genmab to remain competitive in the international market and to be able to attract and retain qualified members of the Board of Directors on a contin-uous basis. To ensure the Board of Directors’ indepen-dence and supervisory function, vesting of restricted stock units (RSUs) granted to members of the Board of Directors shall not be subject to fulfilment of forward-looking perfor-mance criteria. A new member of the Board of Directors may be granted RSUs upon election corresponding to a value (at the time of grant) of up to four (4) times the fixed annual base fee. None Share-Based Compensation In addition the members of the Board of Directors may be granted RSUs corresponding to a value (at the time of grant) of up to one (1) times the fixed annual base fee, for the Chairman the value shall be of up to two (2) times the fixed annual base fee and for the Deputy Chairman the value shall be of up to one point five (1.5) times the fixed annual base fee on an annual basis. None The share-based compensation expense for 2019 of DKK 5 million shown below includes the amortization of the non-cash share-based compensation expense relating to share-based instruments granted over several years. Following an amendment of the guidelines for incen-tive-based remuneration of the Board of Directors and Executive Management by the general meeting in 2014, share-based compensation granted to board members may only be in the form of RSUs. Please refer to note 4.6 for additional information regarding the “Number of RSUs held” and “Number of warrants held” overviews. Financial Statements / Other Disclosures 126

5.1 Remuneration of the Board of Directors and Executive Management – Continued Share-based Compensation Expenses Share-based Compensation Expenses Base Board Fee Committee Fees Base Board Fee Committee Fees (DKK million) 2019 2018 Mats Pettersson Anders Gersel Pedersen Pernille Erenbjerg Paolo Paoletti Rolf Hoffmann Deirdre P. Connelly Peter Storm Kristensen* Rick Hibbert** Daniel J. Bruno* Mijke Zachariasse* 1.2 0.4 0.4 0.4 0.4 0.8 0.4 0.1 0.4 0.3 0.2 0.4 0.3 0.3 0.3 0.5 – – – – 0.8 0.6 0.4 0.4 0.8 0.9 0.4 0.4 0.4 – 2.2 1.4 1.1 1.1 1.5 2.2 0.8 0.5 0.8 0.3 1.2 0.5 0.4 0.4 0.4 0.7 0.4 0.4 0.4 – 0.3 0.3 0.3 0.2 0.3 0.3 – – – – 0.9 0.6 0.5 0.5 0.7 0.7 0.3 0.3 0.3 – 2.4 1.4 1.2 1.1 1.4 1.7 0.7 0.7 0.7 – Total 4.8 2.0 5.1 11.9 4.8 1.7 4.8 11.3 * Employee elected board member ** Stepped down from the Board of Directors at the Annual General Meeting in March 2019 Please refer to the section “Board of Directors” in the Management’s Review for additional information regarding the Board of Directors. Financial Statements / Other Disclosures 127

5.1 Remuneration of the Board of Directors and Executive Management – Continued Remuneration to the Executive Management Purpose and Link to Strategy Performance Metrics Opportunity Changes Compared to 2018 Reflect the individual’s skills and experience, role and responsibilities Any increase based both on individual and company performance as well as benchmark analysis Fixed Effective, January 1, 2019, base salary increased by 3% for the CEO and CFO, and 10% for the CDO in local currency (2018: 3% for CEO, CFO and CDO) Base Salary Provide a framework to save for retirement None Fixed amount or percentage of base salary None Pension and Other Benefits Provide customary ben-efits including car and telephone allowance None Provide sign-on bonus for new executive man-agement A new member of the executive management may receive a sign-on payment upon engagement subject to certain claw-back provisions. None Provide tax equalization payment for executive management CEO received EUR 0.5 million and CFO received USD 0.1 million payments for tax equalization for the higher tax rate in Denmark versus their resident countries of the Netherlands and the United States. CEO received tax equalization payment in 2019 Incentivize executives to achieve key objectives on an annual basis Achievement of predetermined and well-defined annual milestones Maximum 60% to 100% of annual gross salaries dependent on their position. None Annual Cash Bonus Extraordinary bonus of a maximum up to 15% of their annual gross salaries, based on the occurrence of certain special events or achievements. None In 2019, the current Executive Management team received a total cash bonus of DKK 15 million (2018: DKK 11 million). None Financial Statements / Other Disclosures 128

5.1 Remuneration of the Board of Directors and Executive Management – Continued Remuneration to the Executive Management Purpose and Link to Strategy Performance Metrics Opportunity Changes Compared to 2018 Incentivize executives over the longer term aligned to strategy and creation of shareholder value Linked to Genmab’s financial and strate-gic priorities as an incentive to increase the future value of the company but also in recognition of past contributions and accomplishments As a main rule, the members of the executive management may on an annual basis be granted share-based instruments corresponding to a value (at the time of grant) of up to four (4) times the member’s annual base salary, calculated before any pension contribution and bonus payment, in the year of grant. The members of the executive management may on an annual basis be granted share-based instruments corresponding to a value (at the time of grant) of up to four times the member’s annual base salary (2018: two times the member’s annual salary) Share-Based Compensation Notwithstanding the above, in no event may the value (at the time of grant) of share-based instruments granted to a member of the executive management on an annual basis exceed DKK 25 million. Annual grant of share-based instruments to members of the executive manage-ment is used primarily as an incentive to increase the future value of the company but also in recognition of past contributions and accomplishments. Furthermore, a new member of the executive management may be granted share-based instruments upon engagement or promotion. The share-based instruments granted to the members of the executive management may be in the form of restricted stock units or a combination of restricted stock units and warrants (options to subscribe for shares in the company). If members of the executive management are granted a combination of restricted stock units and warrants, the proportional value of the warrants may not exceed 25% of the total value (at the time of grant). Vesting of restricted stock units and warrants granted to members of the executive management may be subject to fulfilment of forward-looking performance criteria as determined by the board of directors. The proportional value of the warrants may not exceed 25% of the total value at the time of grant (2018: 50%). The share-based compensation expense for 2019 of DKK 33 million shown below includes the amortization of the non-cash share-based compensation expense relating to share-based instru-ments granted over several years. In 2019, 25,793 RSUs were granted to the Executive Manage-ment, with a total fair value of DKK 42 million (2018: 50,464 warrants and 18,020 RSUs, with a fair value of DKK 37 million). There were no warrants granted to the Executive Management in 2019. Please refer to note 4.6 for additional information regarding the “Number of RSUs held” and “Number of warrants held” overviews. Financial Statements / Other Disclosures 129

5.1 Remuneration of the Board of Directors and Executive Management – Continued Remuneration to the Executive Management Purpose and Link to Strategy Performance Metrics Opportunity Changes Compared to 2018 Incentivize executives over the longer term aligned to strategy and creation of shareholder value None Each member of the Executive Management shall be required to hold a number of Genmab A/S shares corresponding to the value of such member’s annual base salary: None Shareholding require-ment for members of the Executive Manage-ment • The number of shares shall be fixed at commencement of the employment as, or promotion to, member of the Executive Management May be built up over a five (5) year period from the date of employment or promotion For current members of the Executive Management, the number of shares is finally fixed at the date of adoption of these Remuneration Principles (April 10, 2018) The Board of Directors may diverge from this shareholding requirement • • • The Company shall be entitled to reclaim in full or in part variable components of remuneration paid to the member of the Executive Management on the basis of data, which proved to be misstated Warrants granted to the members of the Executive Management will be subject to an additional two (2) year lock-in period upon vesting Severance Payments In the event Genmab terminates the service agreements with each member of the Executive Management team without cause, Genmab is obliged to pay the Executive Officer his existing salary for one or two years after the end of the one year notice period. However, in the event of termination by Genmab (unless for cause) or by a member of Execu-tive Management as a result of a change of control of Genmab, Genmab is obliged to pay a member of the Executive Management a compen-sation equal to his existing total salary (including benefits) for up to two years in addition to the notice period. It furthermore follows from Genmab’s warrant and RSU programs, that in certain “good leaver” sit-uations outstanding warrants and RSUs awarded under these programs will continue to vest which could potentially make the termination pay-ments exceed two years of remuneration. In case of the termination of the service agreements of the Executive Management without cause, the total impact on our financial position is estimated to approximately DKK 46 million as of December 31, 2019 (2018: DKK 42 million). Please refer to note 5.5 for additional information regarding the potential impact in the event of change of control of Genmab. Defined Contribution Plans Annual Cash Bonus Share-based Compensation Expenses Other Benefits 2019 Base Salary Total (DKK million) Jan van de Winkel David A. Eatwell Judith Klimovsky 7.3 4.3 4.1 1.0 0.1 0.1 3.6 0.9 – 8.4 3.2 3.1 14.9 8.0 9.7 35.2 16.5 17.0 Total 15.7 1.2 4.5 14.7 32.6 68.7 2018 Jan van de Winkel David A. Eatwell Judith Klimovsky 7.1 3.9 3.6 1.2 0.2 0.1 0.2 1.4 0.2 6.4 2.1 2.1 13.4 8.1 5.9 28.3 15.7 11.9 Total 14.6 1.5 1.8 10.6 27.4 55.9 Please refer to the section “Senior Leadership” in the Management’s Review for additional information regarding the Executive Management Financial Statements / Other Disclosures 130

5.1 Remuneration of the Board of Directors and Executive Management – Continued Number of Ordinary Shares Owned and Share-Based Instruments Held December 31, 2018 December 31, 2019 Market Value (DKK million)* Number of Ordinary Shares Owned Acquired Sold Transfers Board of Directors Mats Pettersson Anders Gersel Pedersen Pernille Erenbjerg Paolo Paoletti Rolf Hoffmann Deirdre P. Connelly Peter Storm Kristensen Rick Hibbert** Mijke Zachariasse Daniel J. Bruno 24,800 8,000 2,700 3,337 1,050 2,200 – – – – 7,207 718 478 478 – – 500 – – – – – – (478) – – (300) – – – – – – – – – – – – – 32,007 8,718 3,178 3,337 1,050 2,200 200 – – – 47.4 12.9 4.7 4.9 1.6 3.3 0.3 – – – Total 42,087 9,381 (778) – 50,690 75.1 Executive Management Jan van de Winkel David A. Eatwell Judith Klimovsky 662,400 30,825 – 6,084 49,436 – – – – – – – 668,484 80,261 – 990.4 118.9 – 693,225 55,520 – – 748,745 1,109.3 Total 735,312 64,901 (778) – 799,435 1,184.4 * Market value is based on the closing price of the parent company’s shares on the NASDAQ Copenhagen A/S at the balance sheet date or the last trading day prior to the balance sheet date. ** Stepped down from the Board of Directors at the Annual General Meeting in March 2019. Financial Statements / Other Disclosures 131

5.1 Remuneration of the Board of Directors and Executive Management – Continued Black– Scholes Value Warrants Granted in 2019 Weighted Average Exercise Price Outstanding Warrants December 31, 2018 December 31, 2019 Number of Warrants Held Granted Exercised Expired Transfers (DKK million) – – – – – – 0.2 – 0.2 1.4 Board of Directors Mats Pettersson Anders Gersel Pedersen Pernille Erenbjerg Paolo Paoletti Rolf Hoffmann Deirdre P. Connelly Peter Storm Kristensen* Rick Hibbert** Mijke Zachariasse* Daniel J. Bruno* 26,250 29,000 – – – – 2,515 876 – 15,837 – – – – – – 368 – 351 3,206 (6,250) (9,000) – – – – (500) – – – – – – – – – – – – – – – – – – – – (876) 557 – 20,000 20,000 – – – – 2,383 – 908 19,043 225.90 133.16 – – – – 928.96 – 1,352.72 1,038.68 74,478 3,925 (15,750) – (319) 62,334 1.8 487.74 Executive Management Jan van de Winkel David A. Eatwell Judith Klimovsky 108,068 335,201 36,932 – – – (42,400) (90,000) – – – – – – – 65,668 245,201 36,932 – – – 1,060.39 264.91 1,118.99 – – 480,201 (132,400) – – 347,801 505.80 Total 554,679 3,925 (148,150) – (319) 410,135 1.8 503.05 * Each employee-elected Board Member was granted warrants as an employee of Genmab A/S or its subsidiaries. ** Stepped down from the Board of Directors at the Annual General Meeting in March 2019. Financial Statements / Other Disclosures 132

5.1 Remuneration of the Board of Directors and Executive Management – Continued Following Genmab A/S’ Annual General Meeting on March 29, 2019, the Board of Directors is comprised of five inde-pendent directors, one non-independent director, and three employee-elected directors. Mats Pettersson, Dr. Anders Gersel Pedersen, Deirdre P. Connelly, Pernille Erenbjerg, Rolf Hoffmann and Dr. Paolo Paoletti were re-elected to the Board of Directors for a one year period. Peter Storm Kristensen, Mijke Zachariasse and Dan Bruno were elected to the Board of Directors by the employees for a three year period. Dr. Rick Hibbert stepped down from the Board of Directors. The reclassification of the employee elected board members’ shares and share-based instruments is shown in the trans-ferred column of the tables above. The Board of Directors convened and constituted itself with Mats Pettersson as Chairman and Deirdre P. Connelly as Deputy Chairman. December 31, 2018 December 31, 2019 Fair Value RSUs Granted in 2019 Number of RSUs Held Granted Settled Transfers (DKK million) Board of Directors Mats Pettersson Anders Gersel Pedersen Pernille Erenbjerg Paolo Paoletti Rolf Hoffmann Deirdre P. Connelly Peter Storm Kristensen* Rick Hibbert** Mijke Zachariasse* Daniel J. Bruno* 3,298 2,278 1,649 1,649 1,899 2,094 1,481 1,439 – 4,340 495 247 247 247 247 371 351 – 346 1,157 (957) (718) (478) (478) – – – – – – – – – – – – – (1,439) 188 – 2,836 1,807 1,418 1,418 2,146 2,465 1,832 – 534 5,497 0.8 0.4 0.4 0.4 0.4 0.6 0.6 – 0.6 1.8 20,127 3,708 (2,631) (1,251) 19,953 6.0 Executive Management Jan van de Winkel David A. Eatwell Judith Klimovsky 33,505 20,068 12,579 15,479 – 10,314 (11,387) (7,693) – – – – 37,597 12,375 22,893 24.9 – 16.7 Other than the remuneration to the Board of Directors and the Executive Management and the transactions detailed in the tables above, no other significant transactions with the Board of Directors or the Executive Management took place during 2019. 66,152 25,793 (19,080) – 72,865 41.6 Total 86,279 29,501 (21,711) (1,251) 92,818 47.6 * Each employee-elected Board Member was granted 247 RSUs as a member of the Board of Directors. The remaining RSUs were granted as an employee of Genmab A/S or its subsidiaries. ** Stepped down from the Board of Directors at the Annual General Meeting in March 2019. Financial Statements / Other Disclosures 133

5.2 Related Party Disclosures 5.2 5.4 5.5 Related Party Disclosures Commitments Contingent Assets, Contingent Liabilities and Subsequent Events Genmab’s related parties are: Guarantees and Collaterals There were no bank guarantees as of December 31, 2019 or 2018. • the parent company’s subsidiaries • the parent company’s Board of Directors, Executive Manage-ment, and close members of the family of these persons. Contingent Assets and Liabilities Other Purchase Obligations The group has entered into a number of agreements primarily related to research and development activities. These short term contractual obligations amounted to DKK 564 million as of December 31, 2019, all of which is due in less than two years (2018: DKK 787 million). License and Collaboration Agreements We are entitled to potential milestone payments and royalties on successful commercialization of products developed un-der license and collaboration agreements with our partners. Since the size and timing of such payments are uncertain until the milestones are reached, the agreements may qualify as contingent assets. However, it is impossible to measure the value of such contingent assets, and, accordingly, no such assets have been recognized. Transactions with the Board of Directors and Executive Management Genmab has not granted any loans, guarantees, or other commitments to or on behalf of any of the members of the Board of Directors or Executive Management. We also have certain contingent commitments under our license and collaboration agreements that may become due for future payments. As of December 31, 2019, these contin-gent commitments amounted to approximately DKK 9,520 million (USD 1,426 million) in potential future development, regulatory and commercial milestone payments to third parties under license and collaboration agreements for our pre-clinical and clinical-stage development programs as compared to DKK 5,595 million (USD 858 million) as of December 31, 2018. These milestone payments generally become due and payable only upon the achievement of certain development, clinical, regulatory or commercial milestones. The events triggering such payments or obligations have not yet occurred. Other than the remuneration and other transactions relat-ing to the Board of Directors and Executive Management described in note 5.1, no other significant transactions have taken place with the Board of Directors or the Executive Management during 2019 and 2018. As part of the license and collaboration agreements that Genmab has entered into, once a product is developed and commercialized, Genmab may be required to make milestone and royalty payments. It is impossible to measure the value of such future payments, but Genmab expects to generate future income from such products which will exceed any mile-stone and royalty payments due, and accordingly no such liabilities have been recognized. 5.3 Company Overview Derivative Financial Instruments Genmab has entered into an International Swaps and Deriv-atives Association master agreement. The master agreement with Genmab’s financial institution counterparty also includes a credit support annex which contains provisions that require Genmab to post collateral should the value of the derivative liabilities exceed DKK 50 million (2018: DKK 50 million). As of December 31, 2019 and 2018, Genmab has not been required to post any collateral. There were no outstanding receivables related to derivative financial instruments as of December 31, 2019 or 2018. Genmab A/S (parent company) holds investments either directly or indirectly in the following subsidiaries: In addition to the above obligations, we enter into a variety of agreements and financial commitments in the normal course of business. The terms generally allow us the option to cancel, reschedule and adjust our requirements based on our business needs prior to the delivery of goods or performance of services. It is not possible to predict the maximum potential amount of future payments under these agreements due to the conditional nature of our obligations and the unique facts and circumstances involved in each particular agreement. Ownership Ownership and Votes 2019 and Votes 2018 Name Domicile Genmab B.V. Genmab Holding B.V. Genmab US, Inc. Genmab K.K. Utrecht, the Netherlands Utrecht, the Netherlands New Jersey, USA Tokyo, Japan 100% 100% 100% 100% 100% 100% 100% – Financial Statements / Other Disclosures 134

5.5 Contingent Assets, Contingent Liabilities and Subsequent Events – Continued In addition, the agreement requires Genmab to maintain a cash position of DKK 258.5 million at all times or the counter-party has the right to terminate the agreement. Upon termi-nation, the DKK 50 million (2018: DKK 50 million) threshold amount is no longer applicable and the value of the derivative liability, if any, could be due to the counterparty upon request. Service Agreements with Executive Subsequent Events No events have occurred subsequent to the balance sheet date that could significantly affect the financial statements as of December 31, 2019. Management and Employees The service agreements with each member of the Executive Management may be terminated by Genmab with no less than 12 months’ notice and by the member of the Executive Management with no less than six months’ notice. In the event of a change of control of Genmab, the termination notice due to the member of the Executive Management is extended to 24 months. In the event of termination by Genmab (unless for cause) or by a mem-ber of Executive Management as a result of a change of control of Genmab, Genmab is obliged to pay a member of Executive Management a compensation equal to his existing total salary (including benefits) for up to two years in addition to the notice period. In case of a change of control event and the termination of service agreements of the Executive Management, the total im-pact on our financial position is estimated to approximately DKK 106 million as of December 31, 2019 (2018: DKK 98 million). Accounting Policies Contingent Assets And Liabilities Contingent assets and liabilities are assets and liabilities that arose from past events but whose existence will only be confirmed by the occurrence or non-occurrence of future events that are beyond Genmab’s control. Legal Matter – MorphoSys Patent Infringement Complaint In April 2016, MorphoSys filed a complaint at the U.S. District Court of Delaware against Genmab and Janssen Biotech, Inc. for patent infringement based on activities relating to the manufacture, use and sale of DARZALEX in the United States, which was subsequently amended to include two additional MorphoSys patents. In addition, a further claim by Janssen and us that the three MorphoSys patents were unenforceable due to inequitable conduct by MorphoSys was included in the case. On January 25, 2019, the District Court ruled on summary judgment that the three MorphoSys patents were invalid for lack of enablement. MorphoSys had the opportunity to appeal the District Court’s decision. On January 31, 2019, MorphoSys dismissed its infringement claims against us and Janssen, and we and Janssen, in turn, dismissed our inequitable conduct claims against MorphoSys. As such, there will be no further proceedings in the case. Contingent assets and liabilities are not to be recognized in the financial statements, but are disclosed in the notes. 5.6 Fees to Auditors Appointed at the Annual General Meeting In addition, Genmab has entered into service agreements with 22 (2018: 26) current employees according to which Genmab may become obliged to compensate the employees in connection with a change of control of Genmab. If Genmab as a result of a change of control terminates the service agreement without cause, or changes the working conditions to the detriment of the employee, the employee shall be enti-tled to terminate the employment relationship without further cause with one month’s notice in which case Genmab shall pay the employee a compensation equal to one-half, one or two times the employee’s existing annual salary (including benefits). In case of the change of control event and the termination of all 22 service agreements the total impact on our financial position is estimated to approximately DKK 75 million as of December 31, 2019 (2018: DKK 81 million). (DKK million) 2019 2018 PricewaterhouseCoopers Audit services Audit-related services Tax and VAT services Other services 1.1 0.1 0.4 0.1 1.9 2.3 0.5 2.4 Change of Control In the event of a change of control, change of control clauses are included in some of our collaboration, development and license agreements as well as in service agreements for certain employees. Total 7.1 1.7 Fees for other services than statutory audit of the financial statements provided by PricewaterhouseCoopers Statsauto-riseret Revisionspartnerselskab amounted to DKK 5.2 million (DKK 0.6 million in 2018). Other services than statutory audit of the financial statements comprise services relating to Genmab’s IPO on the Nasdaq in the U.S., tax and VAT com-pliance, agreed-upon procedures, opinions relating to grants, educational training and accounting advice. Collaboration, Development and License Agreements We have entered into collaboration, development and license agreements with external parties, which may be subject to renegotiation in case of a change of control event in Genmab A/S. However, any changes in the agreements are not expect-ed to have significant influence on our financial position. Please refer to note 4.6 for additional information regarding change of control clauses related to share-based instruments granted to the Executive Management and employees. Financial Statements / Other Disclosures 135

5.7 Adjustments to Cash Flow Statement 5.7 5.8 We are also eligible to receive certain additional payments in connection with development, regulatory and sales milestones. Adjustments to Cash Flow Statement Collaborations and Technology Licenses Sales of DARZALEX have grown since it received its first marketing approval in the United States in 2015. In the fourth quarter of 2019, we moved from the 18% royalty tier (applica-ble to net sales exceeding USD 2.0 billion in a calendar year) to the royalty tier of 20% on the portion of net 2019 sales exceeding USD 3.0 billion. The total amount of potential milestone payments under the contract is approximately USD 1,015 million, and to date, we have recorded approximately USD 835 million in milestone payments from Janssen and could be entitled to receive up to USD 180 million in further payments if certain additional milestones are met. Our Collaborations We enter into collaborations with biotechnology and pharmaceutical companies to advance the development and commercialization of our product candidates and to supple-ment our internal pipeline. We seek collaborations that will allow us to retain significant future participation in product sales through either profit-sharing or royalties paid on net sales. Below is an overview of some of our collaborations that have had a significant impact or that we expect may in the near term have a significant impact on our financial results. (DKK million) Note 2019 2018 Adjustments for non–cash transactions: Depreciation, amortization and impairment Share-based compen-sation expenses Other 3.1, 3.2 139 88 2.3, 4.6 147 5 91 – Total adjustments for non–cash transactions 291 179 Collaboration with Novartis (Ofatumumab) Ofatumumab is commercialized by Novartis under a co-development and collaboration agreement with us, which it acquired from GSK in 2015. Under the agreement with Novartis, we are entitled to royalties of 20% of worldwide net sales of ofatumumab for the treatment of cancer and 10% of worldwide net sales for non-cancer treatments, as well as certain potential regulatory and sales milestones, of which only certain sales milestones remain. Novartis is fully responsible for all costs associated with developing and commercializing ofatumumab. Changes in working capital: Receivables Other payables Collaboration with Janssen (Daratumumab/DARZALEX) In August 2012, we entered into a global license, develop-ment, and commercialization agreement with Janssen for daratumumab (marketed as DARZALEX for the treatment of MM). Under this agreement, Janssen is fully responsible for developing and commercializing daratumumab and all costs associated therewith. We receive tiered royalty payments between 12% and 20% based on Janssen’s annual net product sales. The royalties payable by Janssen are limited in time and subject to reduction on a country-by-country basis for customary reduction events, including upon patent expiration or invalidation in the relevant country and upon the first commercial sale of a biosimilar product in the relevant country (for as long as the biosimilar product remains for sale in that country). Pursuant to the terms of the agreement, Janssen’s obligation to pay royalties under this agreement will expire on a country-by-country basis on the later of the date that is 13 years after the first sale of daratumumab in such country or upon the expiration of the last-to-expire relevant product patent (as defined in the agreement) covering daratumumab in such country. (1,658) 440 (768) 134 Total changes in working capital (1,218) (634) Collaboration with Seattle Genetics (Tisotumab vedotin) In October 2011, we entered into a license and collaboration agreement with Seattle Genetics. In August 2017, Seattle Genetics exercised an option it was granted pursuant to this agreement to co-develop and co-commercialize tisotumab vedotin with us. All costs and profits for tisotumab vedotin will be shared on a 50:50 basis. Our cost-sharing arrangement with Seattle Genetics in respect of the co-development and co-commercialization of Financial Statements / Other Disclosures 136

5.8 Collaborations and Technology Licenses – Continued tisotumab vedotin is such that, from time to time, one partner may be required to bear certain costs in furtherance of the collaboration for which it would be entitled to seek reim-bursement of 50% of the costs from the other partner. Such reimbursements may not be immediate or may be offset by other costs incurred or profits received by one or both partners. As a result, we may incur costs for which we are not ultimately responsible, and this may affect our working capital, liquidity and availability of resources for other projects. On the other hand, we may also be responsible for reimbursing Seattle Genetics in respect of the portion of its spending in furtherance of the collaboration for which we are responsible. In addition, we record all development expenses incurred by us in connection with this collaboration as research and development expenses, while reimbursements received from Seattle Genetics related to such development expenses are recorded in revenue as reimbursement income. Our cost sharing arrangement with BioNTech is similar to the one with Seattle Genetics described above with respect to tisotumab vedotin. year period. If Genmab exercises any of these options, it would fund all research and would develop and commercial-ize any resulting product candidates with CureVac eligible to receive between USD 275 million and USD 368 million in de-velopment, regulatory and commercial milestone payments for each product, dependent on the specific product concept. In addition, CureVac is eligible to receive tiered royalties in the range from mid-single digits up to low double digits per product. CureVac would retain an option to participate in de-velopment and/or commercialization of one of the potential additional programs under pre-defined terms and conditions. Further, Genmab made a EUR 20 million equity investment in CureVac. Refer to note 3.4 for additional information regarding Genmab’s equity investment in CureVac. In-Licensed Technology While not material in 2018 or in 2019, in the future, our results and financial condition could be affected by mile-stone payments and royalties related to technology we have licensed or acquired. This includes payments under our asset purchase agreement with IDD Biotech in connection with our development of HexaBody-DR5/DR5, our ADC license agreement with Seattle Genetics in connection with our enapotamab vedotin antibody and our research, collabo-ration and exclusive license agreement with Immatics to discover and develop next-generation bispecific immuno-therapies to target multiple cancer indications. Collaboration with Immatics In July 2018, Genmab entered into a research collaboration and exclusive license agreement with Immatics Biotechnolo-gies GmbH (Immatics) to discover and develop next-generation bispecific immunotherapies to target multiple cancer indica-tions. Genmab received an exclusive license to three propri-etary targets from Immatics, with an option to license up to two additional targets at predetermined economics. Under the terms of the agreement, Genmab paid Immatics an upfront fee of USD 54 million and Immatics is eligible to receive up to USD 550 million in development, regulatory and commercial milestone payments for each product, as well as tiered royalties on net sales. Collaboration with CureVac During December 2019, Genmab entered into a research collaboration and license agreement with CureVac AG. The strategic partnership will focus on the research and develop-ment of differentiated mRNA-based antibody products by combining CureVac’s mRNA technology and know-how with Genmab’s proprietary antibody technologies and expertise. Collaboration with BioNTech (DuoBody-PD-L1x4-1BB and DuoBody-CD40x4-1BB) In May 2015, we entered an agreement with BioNTech to jointly research, develop and commercialize bispecific antibody products using our DuoBody technology platform and antibodies. If BioNTech and us jointly select any product candidates for clinical development, development costs and product ownership will be shared equally going forward. If one of the companies does not wish to move a product candidate forward, the other company is entitled to continue developing the product on predetermined licensing terms. The agreement also includes provisions which will allow the parties to opt out of joint development at key points. Two product candidates are currently in development in connection with this agree-ment, DuoBody-PD-L1x4-1BB and DuoBody-CD40x4-1BB. We submitted CTAs for these products in 2019 and dosed the first patient in a Phase I/II study for DuoBody-PD-L1x4-1BB in May 2019 and dosed the first patient in a Phase I/II for DuoBody-CD40x4-1BB in September 2019. Under the terms of the agreement Genmab will provide CureVac with a USD 10 million upfront payment. The compa-nies will collaborate on research to identify an initial product candidate and CureVac will contribute a portion of the overall costs for the development of this product candidate, up to the time of an investigational New Drug Application. Genmab would thereafter be fully responsible for the development and commercialization of the potential product, in exchange for undisclosed milestones and tiered royalties to CureVac. The agreement also includes three additional options for Genmab to obtain commercial licenses to CureVac’s mRNA technology at pre-defined terms, exercisable within a five-Financial Statements / Other Disclosures 137

Table of Contents Financial Statements for the Parent Company Primary Statements Notes Statements of Comprehensive Income .......................... 139 Balance Sheets............................................................. 140 Accounting Policies ................................................ 143 1 2 3 4 5 6 7 8 9 10 11 12 13 Revenue ................................................................. 144 Statements of Cash Flows ............................................. 141 Statements of Changes in Equity................................... 142 Staff Costs.............................................................. 144 Corporate and Deferred Tax .................................... 145 Intangible Assets.................................................... 146 Property, Plant and Equipment ............................... 147 Leases.................................................................... 148 Other Investments.................................................. 148 Receivables............................................................ 149 Other Payables....................................................... 149 Marketable Securities............................................. 149 Financial Income and Expenses .............................. 149 Remuneration of the Board of Directors and Executive Management.................................... 150 Related Party Disclosures ....................................... 150 Investments in Subsidiaries ................................... 151 Commitments......................................................... 152 Fees to Auditors Appointed at 14 15 16 17 the Annual General Meeting ................................... 153 Adjustments to Cash Flow Statement...................... 153 18 Financial Statements for the Parent Company / Table of Contents 138

Financial Statements for the Parent Income Statement (DKK million) Note 2019 2018 2 Revenue 5,392 3,041 Research and development expenses General and administrative expenses 3, 5, 6 3, 6 (2,235) (354) (1,298) (220) CSotamtepmaennyts of Comprehensive Income Operating expenses (2,589) (1,518) Oper ating result 2,803 1,523 Profit / (Loss) in subsidiaries, net of tax Financial income Financial expenses 15 12 12 (155) 238 (1) (119) 243 (11) Net result before tax 2,885 1,636 4 (719) (164) Corporate tax Net result 2,166 1,472 Statement of Comprehensive Income Net result 2,166 1,472 Other comprehensive income: Amounts which will be re-classified to the income statement: Adjustment of foreign currency fluctuations on subsidiaries 6 10 Total comprehensive income 2,172 1,482 Financial Statements for the Parent Company 139

Primary Assets December 31, 2019 December 31, 2018 (DKK million) Note SBtaalatenmceents Sheets Intangible assets Property, plant and equipment Right-of-use assets Investments in subsidiaries Receivables Deferred tax assets Other investments 5 6 7 15 9 4 8 423 12 34 653 6 65 149 443 11 - 354 4 340 - Total non-current assets 1,342 1,152 Receivables Marketable securities Cash and cash equivalents 9 11 2,976 7,419 3,274 1,330 5,573 478 Total current assets 13,669 7,381 Total assets 15,011 8,533 Shareholders’ Equity and Liabilities December 31, 2019 December 31, 2018 (DKK million) Note Share capital Share premium Other reserves Retained Earnings 65 11,755 98 2,130 61 8,059 92 (198) Total shareholders’ equity 14,048 8,014 Provisions Lease liabilities Other payables 2 23 1 1 - 2 7 10 Total non-current liabilities 26 3 Corporate tax payable Payable to subsidiaries Lease liabilities Other payables 4 10 7 10 73 305 12 547 128 180 - 208 Total current liabilities 937 516 Total liabilities 963 519 Total shareholders’ equity and liabilities 15,011 8,533 Financial Statements for the Parent Company 140

Primary Statements of Cash Flows Statements of Cash Flows (DKK million) Note 2019 2018 Cash flows from operating activities: Net result before tax Reversal of financial items, net Reversal of profit/(loss) in subsidiaries, net of tax Adjustment for non-cash transactions Change in working capital 2,885 (237) 155 246 (1,340) 1,636 (232) 119 146 (668) 12 18 18 Cash generated by operating activities before financial items Interest received Interest elements of lease payments Interest paid Corporate taxes (paid)/received 1,709 111 (1) (13) (476) 1,001 44 – – 46 7 Net cash generated by operating activities 1,330 1,091 Cash flows from investing activities: Investment in intangible assets Investment in tangible assets Transactions with subsidiaries Marketable securities bought Marketable securities sold 5 6 (23) (5) (329) (5,812) 3,940 (398) (6) (69) (3,521) 2,221 11 Net cash used in investing activities (2,229) (1,773) Cash flows from financing activities: Warrants exercised Shares issued for cash Costs related to issuance of shares Principal elements of lease payments Purchase of treasury shares Payment of withholding taxes on behalf of employees on net settled RSUs 65 3,873 (238) (12) – (9) 75 – – – (146) – 7 Net cash from financing activities 3,679 (71) 2,780 478 16 (753) 1,220 11 Changes in cash and cash equivalents Cash and cash equivalents at the beginning of the period Exchange rate adjustments Cash and cash equivalents at the end of the period 3,274 478 Cash and cash equivalents include: Bank deposits and petty cash Short-term marketable securities 2,606 668 478 – Cash and cash equivalents at the end of the period 3,274 478 Financial Statements for the Parent Company 141

Primary Statements of Changes in Equity Share Capital Share Premium Translation Reserves Retained Earnings Shareholders’ Equity (DKK million) Statements Balance at December 31, 2017 61 7,984 82 (1,855) 6,272 Change in accounting policy: Adoption of IFRS 15 – – – 151 151 of in Changes Equity Adjusted total equity at January 1, 2018 61 7,984 82 (1,704) 6,423 Net result Other comprehensive income – – – – – 10 1,472 – 1,472 10 Total comprehensive income Exercise of warrants Purchase of treasury shares Share-based compensation expenses Tax on items recognized directly in equity – – – – – – 75 – – – 10 – – – – 1,472 – (146) 91 89 1,482 75 (146) 91 89 Balance at December 31, 2018 61 8,059 92 (198) 8,014 Net result Other comprehensive income – – – – – 6 2,166 – 2,166 6 Total comprehensive income – – 6 2,166 2,172 Exercise of warrants Shares issued for cash Expenses related to capital increases Share-based compensation expenses Net settlement of RSUs Tax on items recognized directly in equity 1 3 – – – – 64 3,870 (238) – – – – – – – – – – – – 147 (9) 24 65 3,873 (238) 147 (9) 24 Balance at December 31, 2019 65 11,755 98 2,130 14,048 Distribution of the year’s result The Board of Directors proposes that the parent company’s 2019 net income of DKK 2,166 million (2018: net income of DKK 1,472million) be carried forward to next year by transfer to retained earnings. Financial Statements for the Parent Company 142

1 Accounting Policies The financial statements of the parent company have been prepared in accordance with the International Financial Reporting Standards (IFRS) as adopted by the European Union (EU) and further disclosure requirements in the Danish Financial Statements Act. The ROU assets established at January 1, 2019 on the balance sheet was DKK 45 million. Net result decreased by DKK 1 million as a result of adopting IFRS 16 in 2019. Cash flows from operating activities increased by DKK 13 million and cash flows from financing activities decreased by DKK 12 million as a result of adopting IFRS 16 in 2019. Please refer to note 1.1 in the consolidated financial state-ments for a description of the accounting policies of the group. Please refer to note 1.2 in the consolidated financial state-ments for a description of new accounting policies and disclosures of the group. Except for the implementation of IFRS 16, the accounting policies are unchanged from the prior year. The parent company accounting policies are the same as those applied for the Group, with the additions mentioned below. Please refer to note 1.3 in the consolidated financial state-ments for a description of management’s judgments and estimates under IFRS. On adoption of IFRS 16, the parent company recognized lease liabilities in relation to leases that had previously been classified as ‘operating leases’ under the principles of IAS 17 Leases. These liabilities were measured at the present value of the remaining lease payments, discounted using the lessee’s incremental borrowing rate as of January 1, 2019. The weighted average lessee’s incremental borrowing rate applied to the lease liabilities on January 1, 2019 was 3.0%. Supplementary Accounting Policies for the Parent Company Investments in Subsidiaries The equity method is used for measuring the investments in subsidiaries. Under the equity method, the investment in a subsidiary is recognized on initial recognition at cost, and the carrying amount is increased or decreased to recognize the parent company’s share of the profit or loss of the investment after the date of acquisition. The parent company’s share of profit or loss is recognized in the parent company’s profit or loss. The parent company’s share of other comprehensive income arising from the investment is recognized in other comprehensive income of the parent company. The impact of the adoption of IFRS 16 on the financial state-ments as of January 1, 2019 is shown in the table and further described below: January 1, 2019 (DKK million) Operating lease commitments disclosed as at December 31, 2018 Discounted using the parents’s incremental borrowing rate of 3.0% Share-based Compensation Expenses In the financial statements for the parent company, expenses and exercise proceeds related to employees in the subsidiar-ies are allocated to the relevant subsidiary where the em-ployee has entered an employment contract. 47 (2) Lease liability recognized at January 1, 2019 45 Financial Statements for the Parent Company 143

2 3 Revenue Staff Costs (DKK million) (DKK million) 2019 2018 2019 2018 Wages and salaries Share-based compensation Defined contribution plans Other social security costs 140 34 11 13 105 23 7 1 Revenue: Royalties Milestone payments License fees Reimbursement income 3,155 1,869 – 368 1,741 687 348 265 Total 198 136 Total 5,392 3,041 Staff costs are included in the income statement as follows: Revenue split by collaboration partner: Janssen (DARZALEX/daratumumab & DuoBody) Novartis (Arzerra/ofatumumab) Other collaboration partners Research and development expenses General and administrative expenses 148 50 98 38 4,983 23 386 2,390 338 313 Total 198 136 Total 5,392 3,041 Average number of FTE 136 96 Please refer to note 2.1 in the consolidated financial statements for additional information regarding revenue of the group. Number of FTE at year end: 154 113 Please refer to note 2.3 in the consolidated financial statements for additional information regarding staff costs of the group. Financial Statements for the Parent Company 144

4 Corporate and Deferred Tax Taxation – Balance Sheet Significant components of the deferred tax asset are as follows: (DKK million) Taxation — Income Statement & Shareholders’ Equity 2019 2018 (DKK million) 2019 2018 Tax deductible losses Share-Based Instruments Capitalized R&D Costs Other temporary differences – 64 – 1 261 67 4 8 Current tax on result Adjustment to deferred tax Adjustment to valuation allowance 444 275 – 161 255 (252) 65 – 340 – Valuation allowance Total tax for the period in the income statement 719 164 Total deferred tax assets 65 340 A reconciliation of Genmab’s effective tax rate relative to the Danish statutory tax rate is as follows: Please refer to note 2.4 in the consolidated financial statements for additional information regarding corporate and deferred tax of the group. (DKK million) 2019 2018 Net result before tax 2,885 1,636 Computed 22% (2018: 22%) 635 360 Tax effect of: Recognition of previously unrecognized tax losses and deductible temporary differences Non-deductible expenses/non-taxable income and other permanent differences, net All other – (240) 72 12 44 – Total tax effect 84 (196) Total tax for the period in the income statement 719 164 Total tax for the period in shareholders’ equity (24) (89) Financial Statements for the Parent Company 145

5 Licenses, Rights, and Patents Total Intangible Assets (DKK million) Intangible Assets 2019 Cost per January 1 Additions for the year Disposals for the year Exchange rate adjustment 745 75 – – 745 75 – – Cost at December 31 820 820 Accumulated amortization and impairment per January 1 Amortization for the year Impairment for the year Disposals for the year Exchange rate adjustment (302) (95) – – – (302) (95) – – – Accumulated amortization and impairment per December 31 (397) (397) Carrying amount at December 31 423 423 2018 Cost per January 1 Additions for the year Disposals for the year Exchange rate adjustment 347 398 – – 347 398 – – Cost at December 31 745 745 Accumulated amortization and impairment per January 1 Amortization for the year Impairment for the year Disposals for the year Exchange rate adjustment (250) (52) – – – (250) (52) – – – Accumulated amortization and impairment per December 31 (302) (302) Carrying amount at December 31 443 443 2019 2018 Depreciation, amortization, and impairments are included in the income statement as follows: (DKK million) Research and development expenses General and administrative expenses 95 – 52 – Total 95 52 Please refer to note 3.1 in the consolidated financial statements for additional information regarding intangible assets of the group. Financial Statements for the Parent Company 146

6 Leasehold Improvements Equipment, Furniture and Fixtures Total Property, Plant and Equipment (DKK million) Property, Plant and Equipment 2019 Cost at January 1 Additions for the year Disposals for the year 4 – – 20 5 (2) 24 5 (2) Cost at December 31 4 23 27 Accumulated depreciation and impairment at January 1 Depreciation for the year Disposals for the year (1) – – (12) (4) 2 (13) (4) 2 Accumulated depreciation and impairment at December 31 (1) (14) (15) Carrying amount at December 31 3 9 12 2018 Cost at January 1 Additions for the year Disposals for the year 2 2 – 17 4 (1) 19 6 (1) Cost at December 31 4 20 24 Accumulated depreciation and impairment at January 1 Depreciation for the year Disposals for the year – (1) – (11) (2) 1 (11) (3) 1 Accumulated depreciation and impairment at December 31 (1) (12) (13) Carrying amount at December 31 3 8 11 (DKK million) 2019 2018 Depreciation, amortization, and impairments are included in the income statement as follows: Research and development expenses General and administrative expenses 3 1 2 1 Total 4 3 Please refer to note 3.2 in the consolidated financial statements for additional information regarding property, plant and equip-ment of the group. Financial Statements for the Parent Company 147

7 Leases The parent company has entered into lease agreements with respect to office space and office equipment. The leases are non-cancelable for various periods up to 2022. Interest expense is included in net financial items and expenses relating to short-term leases are included in operating expenses in the statement of comprehensive income. Future minimum payments under our leases as of December 31, 2019 and December 31, 2018, are as follows: Amounts recognized in the balance sheet The balance sheet shows the following amounts relating to leases: December 31, 2019 December 31, 2018 December 31, 2019 December 31, 2018 (DKK million) (DKK million) Right-of-use assets Properties Payment due Less than 1 year 1 to 3 years More than 3 years, but less than 5 years More than 5 years 34 – 12 24 – – 11 25 11 – Total right-of-use assets 34 – Lease liabilities Current Non-current 12 23 – – Total 36 47 Please refer to note 3.3 in the consolidated financial statements for additional information regarding leases of the group. Total lease liabilities 35 – There were no additions to the right-of-use assets in 2019. Amounts recognized in the statement of comprehensive income The statement of comprehensive income shows the following amounts relating to leases: 8 Other investments December 31, 2019 December 31, 2018 (DKK million) Please refer to note 3.4 to the consolidated financial statements for additional information on other investments of the group. Depreciation charge of right-of-use assets Properties 11 – Total depreciation charge of right-of-use assets 11 – Interest expense 1 – Financial Statements for the Parent Company 148

9 11 Receivables Marketable Securities Please refer to note 4.4 to the consolidated financial statements for additional information on marketable securities of the group. (DKK million) 2019 2018 Receivables related to collaboration agreements Receivables from subsidiaries Interest receivables Other receivables P repayments 2,849 42 34 11 46 1,266 40 18 7 3 12 Financial Income and Expenses Total 2,982 1,334 Non-current receivables Current receivables 6 2,976 4 1,330 (DKK million) 2019 2018 Total 2,982 1,334 Financial income: Interest and other financial income Interest from subsidiaries Realized and unrealized gains on marketable securities (fair value through the income statement), net Realized and unrealized gains on fair value hedges, net Realized and unrealized exchange rate gains, net Please refer to note 3.5 in the consolidated financial statements for additional information regarding receivables of the group. 120 9 63 1 9 – 100 – 2 177 10 Other Payables Total financial income 238 243 Financial expenses: Interest and other financial expenses Realized and unrealized losses on marketable securities (fair value through the income statement), net 1 – (DKK million) 2019 2018 – 11 Liabilities related to collaboration agreements Staff cost liabilities Other liabilities Payable to subsidiaries Accounts payable 8 20 487 305 33 6 14 152 180 38 Total financial expenses 1 11 Net financial items 237 232 Interest and other financial income on financial assets measured at amortized cost Total at December 31 853 390 22 8 Non-current other payables Current other payables 1 852 2 388 Interest and other financial expenses on financial liabilities measured at amortized cost – – Total at December 31 853 390 Please refer to note 3.7 in the consolidated financial statements for additional information regarding other payables of the group. Please refer to note 4.5 in the consolidated financial statements for additional information regarding financial income and expenses of the group. Financial Statements for the Parent Company 149

13 14 Remuneration of the Board of Directors and Executive Management Related Party Disclosures The total remuneration of the Board of Directors and Executive Management is as follows: Genmab A/S’ related parties are: • • the company’s subsidiaries the company’s Board of Directors, Executive Manage-ment, and close members of the family of these persons. (DKK million) 2019 2018 Wages and salaries Share-based compensation expenses 10 8 9 8 Total 18 17 Transactions with subsidiaries Genmab B.V., Genmab Holding B.V., Genmab US, Inc. and Genmab K.K. are 100% (directly or indirectly) owned subsid-iaries of Genmab A/S and are included in the consolidated financial statements. They perform certain research & de-velopment, general & administrative, and management ac-tivities on behalf of the parent company. Genmab B.V. owns the HexaBody technology and the parent company performs certain research and development activities related to the HexaBody technology on behalf of Genmab B.V. All intercom-pany transactions have been eliminated in the consolidated financial statements of the Genmab group. The remuneration of each of the Executive Management is described below: Defined Contribution Plans Annual Cash Bonus Share-based Compensation Expenses Other Benefits 2019 Base Salary Total (DKK million) Jan van de Winkel David A. Eatwell Judith Klimovsky 0.7 0.4 0.4 – – – – – – 1.3 – 0.2 1.5 0.8 1.0 3.5 1.2 1.6 – – Total 1.5 1.5 3.3 6.3 2018 (DKK million) Jan van de Winkel David A. Eatwell Judith Klimovsky 0.7 0.4 0.4 – – – – – – 1.1 – – 1.3 0.8 0.6 3.1 1.2 1.0 – – Total 1.5 1.1 2.7 5.3 Remuneration of the Board of Directors for the parent is the same as disclosed in note 5.1 in the consolidation financial statements. Please refer to note 5.1 in the consolidated financial statements for additional information regarding the remuneration of the Board of Directors and Executive Management. Financial Statements for the Parent Company 150

15 Investments in Subsidiaries Genmab A/S (parent company) holds investments either directly or indirectly in the following subsidiaries: (DKK million) 2019 2018 Ownership and Votes 2019 Ownership and Votes 2018 Name Domicile Transactions with subsidiaries: Income statement: Service fee income Service fee costs Financial income Genmab B.V. Genmab Holding B.V. Genmab US, Inc. Genmab K.K. Utrecht, the Netherlands Utrecht, the Netherlands New Jersey, USA Tokyo, Japan 100% 100% 100% 100% 100% 100% 100% – 26 (937) 9 15 (546) 1 Balances with subsidiaries: Current receivables Current payables 42 (305) 40 (180) (DKK million) 2019 2018 Cost per January 1 Additions 560 448 560 – Genmab A/S has placed at each subsidiary’s disposal a cred-it facility (denominated in local currency) that the subsidi-ary may use to draw from in order to secure the necessary funding of its activities. Cost per December 31 1,008 560 Value adjustments January 1 Profit/(loss) in subsidiaries, net of tax Exchange rate adjustment (206) (155) 6 (98) (118) 10 Please refer to note 5.2 to the consolidated financial state-ments for additional information regarding transactions with related parties of the group. Value adjustments per December 31 (355) (206) Investments in subsidiaries per December 31 653 354 Financial Statements for the Parent Company 151

16 Commitments commitments amounted to approximately DKK 6,322 million (USD 947 million) in potential future development, regulatory and commercial milestone payments to third parties under license and collaboration agreements for our pre-clinical and clinical-stage development programs as compared to DKK 4,871 million (USD 747 million) as of December 31, 2018. These milestone payments generally become due and payable only upon the achievement of certain development, clinical, regulatory or commercial milestones. The events triggering such payments or obligations have not yet occurred. cancel, reschedule and adjust our requirements based on our business needs prior to the delivery of goods or performance of services. It is not possible to predict the maximum potential amount of future payments under these agreements due to the conditional nature of our obligations and the unique facts and circumstances involved in each particular agreement. Guarantees and Collaterals There were no bank guarantees as of December 31, 2019 or 2018. Other Purchase Obligations The parent company has entered into a number of agreements primarily related to research and development activities carried out by Genmab. In the parent company, the contractual obligations amounted to DKK 438 million (2018: DKK 787 million). Please refer to note 5.4 in the consolidated financial state-ments for additional information regarding commitments of the group. We also have certain contingent commitments under our li-cense and collaboration agreements that may become due for future payments. As of December 31, 2019, these contingent In addition to the above obligations, we enter into a variety of agreements and financial commitments in the normal course of business. The terms generally allow us the option to Financial Statements for the Parent Company 152

17 18 Fees to Auditors Appointed at the Annual General Meeting Adjustments to Cash Flow Statement (DKK million) Note (DKK million) 2019 2018 2019 2018 Adjustments for non–cash transactions: Depreciation, amortization and impairment Share-based compensation expenses PricewaterhouseCoopers Audit services Audit-related services Tax and VAT services Other services 1.7 2.3 0.5 2.4 0.8 0.1 0.4 0.1 5, 6 3 99 147 55 91 Total adjustments for non–cash transactions 246 146 Changes in working capital: Receivables Other payables Total 6.9 1.4 (1,640) 300 (762) 94 Fees for other services than statutory audit of the financial statements provided by Price-waterhouseCoopers Statsautoriseret Revisionspartnerselskab amounted to DKK 5.2 million (DKK 0.6 million in 2018). Other services than statutory audit of the financial statements comprise services relating to Genmab’s IPO on the Nasdaq U.S., tax and VAT compliance, agreed-upon procedures, opinions relating to grants, educational training and accounting advice. Total changes in working capital (1,340) (668) Please refer to note 5.7 in the consolidated financial statements for additional information regarding adjustments to the cash flow statement of the group. Please refer to note 5.6 in the consolidated financial statements for additional information regarding fees to auditors of the group. Financial Statements for the Parent Company 153

Directors’ and Management’s Statement on the Annual Report The Board of Directors and Executive Management have today considered and adopted the Annual Report of Genmab A/S for the financial year 1 January to 31 December 2019. In our opinion, the Consolidated Financial Statements and the Parent Company Financial Statements give a true and fair view of the financial position at 31 December 2019 of the Group and the Parent Company and of the results of the Group and Parent Company operations and cash flows for 2019. results for the year and of the financial position of the Group and the Parent Company as well as a description of the most significant risks and elements of uncertainty facing the Group and the Parent Company. The Annual Report has been prepared in accordance with International Financial Reporting Standards as adopted by the EU and further requirements in the Danish Financial Statements Act. We recommend that the Annual Report be adopted at the Annual General Meeting. In our opinion, Management’s Review includes a true and fair account of the development in the operations and financial circumstances of the Group and the Parent Company, of the Copenhagen, February 19, 2020 Executive Management Board of Directors Jan van de Winkel (President & CEO) Mats Pettersson (Chairman) Deirdre P. Connelly (Deputy Chairman) Rolf Hoffmann Pernille Erenbjerg David A. Eatwell (Executive Vice President & CFO) Paolo Paoletti Anders Gersel Pedersen Mijke Zachariasse (Employee elected) Daniel J. Bruno (Employee elected) Judith Klimovsky (Executive Vice President & CDO) Peter Storm Kristensen (Employee elected) Directors’ and Management’s Statement on the Annual Report 154

Independent Auditor’s Report To the shareholders of Genmab A/S Appointment Following the listing of the shares of Genmab A/S on Nasdaq Copenhagen, we were first appointed auditors of Genmab A/S on 22 March 2001. We have been reappointed annually by shareholder resolution for a total period of uninterrupted engagement of 19 years including the financial year 2019. Our opinion In our opinion, the Consolidated Financial Statements and the Parent Company Financial Statements give a true and fair view of the Group’s and the Parent Company’s financial po-sition at 31 December 2019 and of the results of the Group’s and the Parent Company’s operations and cash flows for the financial year 1 January to 31 December 2019 in accordance with International Financial Reporting Standards as adopted by the EU and further requirements in the Danish Financial Statements Act. Basis for opinion We conducted our audit in accordance with International Standards on Auditing (ISAs) and the additional require-ments applicable in Denmark. Our responsibilities under those standards and requirements are further described in the Auditor’s responsibilities for the audit of the Financial Statements section of our report. We believe that the audit evidence we have obtained is suf-ficient and appropriate to provide a basis for our opinion. Key audit matters Key audit matters are those matters that, in our professional judgment, were of most significance in our audit of the Fi-nancial Statements for 2019. These matters were addressed in the context of our audit of the Financial Statements as a whole, and in forming our opinion thereon, and we do not provide a separate opinion on these matters. Our opinion is consistent with our Auditor’s Long-form Report to the Audit and Finance Committee and the Board of Directors. Independence We are independent of the Group in accordance with the International Ethics Standards Board for Accountants’ Code of Ethics for Professional Accountants (IESBA Code) and the additional requirements applicable in Denmark. We have also fulfilled our other ethical responsibilities in accordance with the IESBA Code. What we have audited The Consolidated Financial Statements and Parent Company Financial Statements of Genmab A/S for the financial year 1 January to 31 December 2019 comprise income statement and statements of comprehensive income, balance sheets, statements of cash flows, statements of changes in equity and notes, including summary of significant accounting policies for the Group as well as for the Parent Company. Collectively referred to as the “Financial Statements.” To the best of our knowledge and belief, prohibited non-audit services referred to in Article 5(1) of Regulation (EU) No 537/2014 were not provided. Independent Auditor’s Report 155

Financial Statements and the Parent Company Financial Statements and has been prepared in accordance with the requirements of the Danish Financial Statements Act. We did not identify any material misstatement in Management’s Review. Management’s responsibilities for the Financial Statements Management is responsible for the preparation of consoli-dated financial statements and parent company financial statements that give a true and fair view in accordance with International Financial Reporting Standards as adopted by the EU and further requirements in the Danish Financial Statements Act, and for such internal control as Management determines is necessary to enable the preparation of financial statements that are free from material misstate-ment, whether due to fraud or error. Revenue recognition involve accounting for license and collab-consistently. In preparing the Financial Statements, Management is responsible for assessing the Group’s and the Parent Com-pany’s ability to continue as a going concern, disclosing, as applicable, matters related to going concern and using the going concern basis of accounting unless Management either intends to liquidate the Group or the Parent Company or to cease operations, or has no realistic alternative but to do so. materially inconsistent with the Financial Statements or our knowledge obtained in the audit, or otherwise appears to be materially misstated. Statement on Management’s Review Management is responsible for Management’s Review. Our opinion on the Financial Statements does not cover Management’s Review, and we do not express any form of assurance conclusion thereon. Moreover, we considered whether Management’s Review includes the disclosures required by the Danish Financial Statements Act. Auditor’s responsibilities for the audit of the Financial Statements Our objectives are to obtain reasonable assurance about whether the Financial Statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditor’s report that includes our opinion. In connection with our audit of the Financial Statements, our responsibility is to read Management’s Review and, in doing so, consider whether Management’s Review is Based on the work we have performed, in our view Manage-ment’s Review is in accordance with the Consolidated Independent Auditor’s Report 156 Key audit matterHow our audit addressed the key audit matter Revenue recognition on research and development and collaboration agreementsWe discussed revenue recognition principles with Management. Revenue is recognized when a performance obligation is satisfied Our audit procedures in regard of revenue recognition included i.e. when Genmab’s customer obtains control of promisedtesting of relevant internal controls. goods or services, in an amount that reflects the consideration that Genmab expects to receive in exchange for those goods orWe read relevant agreements to assess whether the revenue services.recognition was consistent with the accounting standard IFRS 15, Revenue from Contracts with Customers, and had been applied oration agreements including simultaneous transactions and multiple performance obligations such as upfront payments,We considered the reasonableness of the judgments made by milestone payments, royalties and reimbursement of costs.Management in determining the relevant assumptions utilized in calculating recognized revenue. We focused on this area because timing of revenue recognition in the income statement has inherent complexities and requiresWe tested a sample of transactions of revenue recognized for significant judgment and estimation by management. accurate calculation and appropriately recognition based on agreements, recognition principles and Managements estimates Reference is made to note 2.1.and judgments.

Reasonable assurance is a high level of assurance, but is not a guarantee that an audit conducted in accordance with ISAs and the additional requirements applicable in Denmark will always detect a material misstatement when it exists. • Conclude on the appropriateness of Management’s use of the going concern basis of accounting and based on the audit evidence obtained, whether a material uncertainty exists related to events or conditions that may cast significant doubt on the Group’s and the Parent Compa-ny’s ability to continue as a going concern. If we conclude that a material uncertainty exists, we are required to draw attention in our auditor’s report to the related disclosures in the Financial Statements or, if such disclosures are inadequate, to modify our opinion. Our conclusions are based on the audit evidence obtained up to the date of our auditor’s report. However, future events or conditions may cause the Group or the Parent Company to cease to continue as a going concern. Evaluate the overall presentation, structure and content of the Financial Statements, including the disclosures, and whether the Financial Statements represent the underlying transactions and events in a manner that achieves fair presentation. Obtain sufficient appropriate audit evidence regarding the financial information of the entities or business activities within the Group to express an opinion on the Consoli-dated Financial Statements. We are responsible for the direction, supervision and performance of the group audit. We remain solely responsible for our audit opinion. We also provide those charged with governance with a statement that we have complied with relevant ethical requirements regarding independence, and to communicate with them all relationships and other matters that may reasonably be thought to bear on our independence, and where applicable, related safeguards. Misstatements can arise from fraud or error and are consid-ered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these Financial Statements. As part of an audit in accordance with ISAs and the additional requirements applicable in Denmark, we exercise profession-al judgment and maintain professional skepticism through-out the audit. We also: From the matters communicated with those charged with gov-ernance, we determine those matters that were of most signi-ficance in the audit of the Financial Statements of the current period and are therefore the key audit matters. We describe these matters in our auditor’s report unless law or regulation precludes public disclosure about the matter or when, in ex-tremely rare circumstances, we determine that a matter should not be communicated in our report because the adverse con-sequences of doing so would reasonably be expected to out-weigh the public interest benefits of such communication. • Identify and assess the risks of material misstatement of the Financial Statements, whether due to fraud or error, design and perform audit procedures responsive to those risks, and obtain audit evidence that is sufficient and appropriate to provide a basis for our opinion. The risk of not detecting a material misstatement resulting from fraud is higher than for one resulting from error, as fraud may involve collusion, forgery, intentional omissions, mis-representations, or the override of internal control. Obtain an understanding of internal control relevant to the audit in order to design audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of the Group’s and the Parent Company’s internal control. Evaluate the appropriateness of accounting policies used and the reasonableness of accounting estimates and related disclosures made by Management. • Hellerup, 19 February 2020 PricewaterhouseCoopers Statsautoriseret Revisionspartnerselskab CVR no 33 77 12 31 • • We communicate with those charged with governance regarding, among other matters, the planned scope and timing of the audit and significant audit findings, including any significant deficiencies in internal control that we identify during our audit. Rasmus Friis Jørgensen State Authorised Public Accountant mne 28705 Allan Knudsen State Authorised Public Accountant mne 29465 • Independent Auditor’s Report 157

Glossary ment, diagnosis, or preven-tion of serious conditions when compared to standard applications. American Depository Shares (ADSs) A U.S. dollar-denomi-nated equity share of a foreign-based company available for purchase on an American stock exchange. Bispecific antibody An antibody in which the two binding regions are not identical, with each region directed against two differ-ent antigens or against two different sites on the same antigen. Dual-listed company A company whose shares are traded on two stock markets. Initial Public Offering (IPO) An initial public offering of a company’s stock Target A molecule of potential interest against which an antibody is raised/created. Marketing Authorization Epitope The specific surface portion of an antigen to which an antibody binds. Upon binding of the antibody to the epitope an immune response is elicited. Application (MAA) A submission to apply for marketing approval for a drug from the EMA. Progression Free Survival Transgenic mouse A mouse carrying a trans-gene from a foreign species, typically a human, which transgene has been intro-duced into the replicating cells of the mouse, so the transgene is passed on to future generations/offspring of the transgenic mouse. (PFS) The length of time a patient lives without his/her disease worsening. Antibody-drug conjugate (ADC) Antibody with potent cyto-toxic agents (toxins) coupled to it. BREEAM (Building Research Establishment Environmen-tal Assessment Method) A sustainability assessment method for infrastructure and buildings. Monoclonal Derived from a single cell. Monoclonal antibodies derived from such single cell will be identical. Proteasome inhibitor (PI) A type of drug used to treat certain types of cancer, such as multiple myeloma. Exam-ples include bortezomib and carfilzomib. European Medicines Antigen Immunogen. A target molecule that is specifically bound by an antibody. Agency (EMA) European regulatory agency that facilitates development and access to medicines, evaluates applications for marketing authorization and monitors the safety of medicines. Clinical Term used to refer to drugs that are at the stage of being investigated in humans to determine the safety and efficacy of the drug before it can be submitted for approval by regulatory authorities. Monotherapy Treatment of a medical condi-tion by use of a single drug. U.S. Food and Drug Administration (FDA) U.S. regulatory agency responsible for ensuring the safety, efficacy and security of human and veterinary drugs, biological products and medical devices. Subcutaneous (SubQ) Applied under the skin. Apoptosis A form of programmed cell death. Pre-clinical Term used to refer to drugs that are at the stage of being investigated in the laboratory or in animals to determine the safety and efficacy of the drug before it is tested in humans. Real-Time Oncology Review (RTOR) Pilot Program Allows the U.S. FDA to review data prior to the completed formal submission of a sBLA. Biologics License Hexamerization The ordered clustering of six antibodies. Application (BLA) A submission to apply for marketing approval from the U.S. FDA, which contains specific information on the manufacturing processes, chemistry, pharmacology, clinical pharmacology and the medical effects of a biologic product. Complement dependent cytotoxicity (CDC) An antibody effector function that eliminates target cells. Immunomodulatory agent A type of drug used to treat certain types of cancers, such as multiple myeloma. Examples include lenalido-mide and pomalidomide. Refractory Resistant to treatment. Priority Review FDA designation used for drugs that, if approved, would be significant im-provements in the safety or effectiveness of the treat-Relapsed Recurrence of disease symptoms after a period of improvement. Cytotoxic Toxic to living cells. Glossary 158

Forward Looking Statement This annual report contains forward looking statements. The words “believe”, “expect”, “anticipate”, “intend” and “plan” and similar expressions identify forward looking statements. Actual results or performance may differ materially from any future results or performance expressed or implied by such statements. The important factors that could cause our actual results or performance to differ materially include, among others, risks associated with product discovery and development, uncertainties related to the outcome and conduct of clinical trials including unforeseen safety issues, uncertainties related to product manufacturing, the lack of market acceptance of our products, our inability to manage growth, the competitive environment in relation to our business area and markets, our inability to attract and retain suitably qualified personnel, the unenforceability or lack of protection of our patents and proprietary rights, our relationships with affiliated entities, changes and developments in technology which may render our products obsolete, and other factors. For a further discussion of these risks, please refer to the section “Risk Management” in this annual report and the risk factors included in Genmab’s final prospectus for our U.S. public offering and listing and other filings with the U.S. Securities and Exchange Commission (SEC). Genmab does not undertake any obligation to update or revise forward looking statements in this annual report nor to confirm such statements to reflect subsequent events or circumstances after the date made or in relation to actual results, unless required by law. Genmab A/S and/or its subsidiaries own the following trademarks: Genmab®; the Y-shaped Genmab logo®; Genmab in combination with the Y-shaped Genmab logo®; HuMax®; DuoBody®; DuoBody in combination with the DuoBody logo®; HexaBody®; HexaBody in combination with the HexaBody logo®; DuoHexaBody®; HexElect®; and UniBody®. Arzerra® is a trademark of Novartis AG or its affiliates. DARZALEX® is a trademark of Janssen Pharmaceutica NV. OmniAb® is a trademark of Open Monoclonal Technology, Inc. UltiMAb® is a trademark of Medarex, Inc. Opdivo® is a trademark of Bristol-Myers Squibb Company. Velcade® and NINLARO® are trademarks of Millennium Pharmaceuticals. Revlimid® and Pomalyst® are trademarks of Celgene Corporation. Venclexta® is a trademark of AbbVie, Inc. Tecentriq® is a trademark of Genentech, Inc. TEPEZZA™ is a trademark of Horizon Therapeutics plc About Genmab A/S Genmab is a publicly traded, international biotechnology company specializing in the creation and development of differentiated antibody therapeutics for the treatment of cancer. Founded in 1999, the company is the creator of three approved antibodies: DARZALEX® (daratumumab, under agreement with Janssen Biotech, Inc.) for the treatment of certain multiple myeloma indications in territories including the U.S., Europe and Japan, Arzerra® (ofatumumab, under agreement with Novartis AG), for the treatment of certain chronic lymphocytic leukemia indications in the U.S., Japan and certain other territories and TEPEZZA™ (teprotumumab, under agreement with Roche granting sublicense to Horizon Therapeutics plc) for the treatment of thyroid eye disease in the U.S. Daratumumab is in clinical development by Janssen for the treatment of additional multiple myeloma indications, other blood cancers and amyloidosis. A SubQ formulation of ofatumumab is in development by Novartis for the treatment of RMS. Genmab also has a broad clinical and pre-clinical product pipeline. Genmab’s technology base consists of validated and proprietary next generation antibody technologies – the DuoBody® platform for generation of bispecific antibodies, the HexaBody® platform, which creates effector function enhanced antibodies, the HexElect® platform, which combines two co-dependently acting HexaBody molecules to introduce selectivity while maximizing therapeutic potency and the DuoHexaBody® platform, which enhances the potential potency of bispecific antibodies through hexamerization. The company intends to leverage these technologies to create opportunities for full or co-ownership of future products. Genmab has alliances with top tier pharmaceutical and biotechnology companies. Genmab is headquartered in Copenhagen, Denmark with sites in Utrecht, the Netherlands, Princeton, New Jersey, U.S and Tokyo, Japan. ©2020, Genmab A/S. All rights reserved. Design & Layout Kontrapunkt Photographers Tuala Hjarnø, 3FX, Inc. Forward Looking Statement 159

Genmab A/S Kalvebod Brygge 43 1560 Copenhagen V Denmark T. +45 70 20 27 28 Genmab US, Inc. 902 Carnegie Center Suite 301 Princeton, NJ 08540 USA T. +1 609 430 2481 Genmab B.V. & Genmab K.K. Level 21 Shiodome Shibarikyu Building 1-2-3 Kaigan, Minato-ku Tokyo 105-0022 Japan T. +81 3 5403 6330 Genmab Holding B.V. Uppsalalaan 15 3584 CT Utrecht The Netherlands T. +31 30 2 123 123 www.genmab.com LEI Code 529900MTJPDPE4MHJ122